STRINGSTRING
IL6 IL6 SLAMF1 SLAMF1 IL12B IL12B BCL2L1 BCL2L1 CSNK2A1 CSNK2A1 RAB9B RAB9B BAX BAX CYCS CYCS CD3G CD3G CD3D CD3D CD3E CD3E CDKN1B CDKN1B IRF3 IRF3 BAD BAD MAVS MAVS TLR4 TLR4 IL2 IL2 NFKB1 NFKB1 TLR7 TLR7 RAB9A RAB9A CBLB CBLB APAF1 APAF1 MYD88 MYD88 DDX58 DDX58 TRAF3 TRAF3 RCHY1 RCHY1 FADD FADD CCND1 CCND1 FOS FOS PIK3CA PIK3CA PIK3R1 PIK3R1 EIF2AK3 EIF2AK3 JAK1 JAK1 IL1B IL1B IL1A IL1A EIF2AK1 EIF2AK1 PIK3R2 PIK3R2 RACK1 RACK1 OAS1 OAS1 OAS3 OAS3 OAS2 OAS2 EIF2S1 EIF2S1 RELA RELA IL12A IL12A NFKBIA NFKBIA BID BID AKT3 AKT3 CCND3 CCND3 IFIH1 IFIH1 LOC103665481 LOC103665481 IL2RA IL2RA FAS FAS MAP3K7 MAP3K7 EIF2AK4 EIF2AK4 ENSUMAP00000018272 ENSUMAP00000018272 HSPA1L HSPA1L HSPA2 HSPA2 CCNE1 CCNE1 CASP3 CASP3 CSNK2B CSNK2B EIF2AK2 EIF2AK2 CCND2 CCND2 CD209 CD209 PIK3CB PIK3CB MAPK8 MAPK8 IL2RB IL2RB LOC103662147 LOC103662147 CDK2 CDK2 TLR2 TLR2 CCNE2 CCNE2 TP53 TP53 STAT2 STAT2 MSN MSN TRAF6 TRAF6 CDK6 CDK6 IKBKG IKBKG LOC103681299 LOC103681299 AKT2 AKT2 ADAR ADAR FASLG FASLG IFNAR1 IFNAR1 CDK4 CDK4 TRADD TRADD STAT1 STAT1 TBK1 TBK1 EIF3H EIF3H CASP8 CASP8 CASP9 CASP9 CD28 CD28 LOC103672496 LOC103672496 LOC103672499 LOC103672499 IL2RG IL2RG HSPA8 HSPA8 IRF9 IRF9 CHUK CHUK FCGR2B FCGR2B STAT5B STAT5B TNFAIP3 TNFAIP3 PIK3R3 PIK3R3 IRAK4 IRAK4 MAPK9 MAPK9 LOC103680386 LOC103680386 AKT1 AKT1 MAPK10 MAPK10 STAT5A STAT5A STAT3 STAT3 GSK3B GSK3B IKBKB IKBKB MX1 MX1 MX2 MX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6. (189 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X2. (338 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
CSNK2A1LOW QUALITY PROTEIN: casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
BAXApoptosis regulator BAX. (221 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (182 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (185 aa)
IRF3Interferon regulatory factor 3 isoform X2. (421 aa)
BADBcl2-associated agonist of cell death. (168 aa)
MAVSLOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (710 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
RAB9ARas-related protein Rab-9A. (201 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1252 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
DDX58Probable ATP-dependent RNA helicase DDX58 isoform X1. (928 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
RCHY1RING finger and CHY zinc finger domain-containing protein 1 isoform X1. (261 aa)
FADDFAS-associated death domain protein. (192 aa)
CCND1G1/S-specific cyclin-D1. (74 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (963 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (331 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (244 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1. (627 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1. (374 aa)
OAS12'-5'-oligoadenylate synthetase 1. (400 aa)
OAS32'-5'-oligoadenylate synthase 3. (1031 aa)
OAS22'-5'-oligoadenylate synthase 2 isoform X2. (711 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
RELATranscription factor p65. (585 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (237 aa)
IFIH1Interferon-induced helicase C domain-containing protein 1 isoform X1. (1016 aa)
LOC103665481Putative Bcl-2 homologous antagonist/killer 2. (349 aa)
IL2RAInterleukin-2 receptor subunit alpha isoform X1. (267 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1595 aa)
ENSUMAP00000018272Heat shock 70 kDa protein 1-like. (301 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (407 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (250 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (542 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (299 aa)
CD209CD209 antigen isoform X1. (249 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
IL2RBInterleukin-2 receptor subunit beta. (551 aa)
LOC103662147Interferon alpha-1/2-like. (197 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
TLR2LOW QUALITY PROTEIN: toll-like receptor 2; Belongs to the Toll-like receptor family. (743 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
STAT2Signal transducer and activator of transcription. (848 aa)
MSNLOW QUALITY PROTEIN: moesin. (577 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CDK6Cyclin-dependent kinase 6. (278 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
LOC103681299Ras-related protein Rab-9A-like. (201 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
ADARDouble-stranded RNA-specific adenosine deaminase. (1150 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
IFNAR1Interferon alpha/beta receptor 1. (557 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
STAT1Signal transducer and activator of transcription. (809 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (352 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (413 aa)
CD28T-cell-specific surface glycoprotein CD28. (277 aa)
LOC103672496Membrane cofactor protein-like isoform X1. (415 aa)
LOC103672499Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (371 aa)
IL2RGCytokine receptor common subunit gamma isoform X2. (374 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
IRF9Interferon regulatory factor 9 isoform X1. (434 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
FCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b isoform X1. (299 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (714 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC103680386Interferon alpha-1/2-like. (187 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
STAT3Signal transducer and activator of transcription. (838 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
MX1Interferon-induced GTP-binding protein Mx1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (660 aa)
MX2Interferon-induced GTP-binding protein Mx2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (712 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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