STRINGSTRING
IL6 IL6 GNA13 GNA13 PTK2B PTK2B BAX BAX CYCS CYCS CALML6 CALML6 GNB1 GNB1 LOC103663361 LOC103663361 CREB5 CREB5 IL10RA IL10RA LOC103670936 LOC103670936 ADCY9 ADCY9 IRF3 IRF3 GNG5 GNG5 PRKACB PRKACB ROCK2 ROCK2 KRAS KRAS ITPR2 ITPR2 MAPK1 MAPK1 PDGFRA PDGFRA CRKL CRKL SRC SRC CTNNB1 CTNNB1 PRKACA PRKACA CCR5 CCR5 CCR3 CCR3 GNB3 GNB3 PPP3CC PPP3CC PPP3CA PPP3CA NFKB1 NFKB1 HRAS HRAS VEGFA VEGFA CXCR4 CXCR4 CALR CALR CALM1 CALM1 CXCL8 CXCL8 GNG7 GNG7 FADD FADD CREB3 CREB3 GNG4 GNG4 CCND1 CCND1 SOS2 SOS2 GNA12 GNA12 TNFRSF1A TNFRSF1A PLCB4 PLCB4 GNB4 GNB4 PTGER4 PTGER4 MAP2K6 MAP2K6 B2M B2M PIK3CA PIK3CA PIK3R1 PIK3R1 PDIA3 PDIA3 JAK1 JAK1 IL1B IL1B LOC103672268 LOC103672268 GRB2 GRB2 EGFR EGFR EIF4EBP1 EIF4EBP1 E2F3 E2F3 PIK3R2 PIK3R2 PPP3CB PPP3CB LOC103656357 LOC103656357 CRK CRK MAPK14 MAPK14 SP1 SP1 RELA RELA GNB2 GNB2 MAPK3 MAPK3 NFKBIA NFKBIA PRKCG PRKCG BID BID NRAS NRAS AKT3 AKT3 CALML4 CALML4 CALML5 CALML5 LOC103665481 LOC103665481 MAP2K1 MAP2K1 MB21D1 MB21D1 FAS FAS TAP1 TAP1 TAP2 TAP2 RPS6KB2 RPS6KB2 E2F2 E2F2 SOS1 SOS1 GNAI3 GNAI3 CASP3 CASP3 GNG2 GNG2 GNAI1 GNAI1 ATF4 ATF4 GNG3 GNG3 PTGER2 PTGER2 ENSUMAP00000020007 ENSUMAP00000020007 PIK3CB PIK3CB TNF TNF CREB3L1 CREB3L1 ATF2 ATF2 CCL2 CCL2 GNGT2 GNGT2 STING1 STING1 LOC103662147 LOC103662147 ITGB3 ITGB3 CREB3L2 CREB3L2 CXCL12 CXCL12 TSC1 TSC1 CCL5 CCL5 CCL4 CCL4 LOC103667299 LOC103667299 LOC103667298 LOC103667298 CCL3L3 CCL3L3 TP53 TP53 RAF1 RAF1 RB1 RB1 ITGAV ITGAV RIPK1 RIPK1 CDK6 CDK6 NFATC3 NFATC3 IKBKG IKBKG AKT2 AKT2 GNB5 GNB5 LOC103662893 LOC103662893 LOC103662772 LOC103662772 ROCK1 ROCK1 GNGT1 GNGT1 GNG11 GNG11 FASLG FASLG LOC103673110 LOC103673110 CDK4 CDK4 PTK2 PTK2 TRADD TRADD CREB3L4 CREB3L4 TBK1 TBK1 PTGS2 PTGS2 MDM2 MDM2 IL1R1 IL1R1 ADCY2 ADCY2 PRKCA PRKCA TRAF5 TRAF5 PPP3R1 PPP3R1 GNG13 GNG13 CASP8 CASP8 CX3CL1 CX3CL1 CASP9 CASP9 ADCY8 ADCY8 ADCY3 ADCY3 CREB1 CREB1 RPS6KB1 RPS6KB1 CHUK CHUK RHOA RHOA ADCY4 ADCY4 NFATC4 NFATC4 GNAQ GNAQ MTOR MTOR ARHGEF12 ARHGEF12 GNG8 GNG8 PIK3R3 PIK3R3 ITPR1 ITPR1 E2F1 E2F1 NFATC2 NFATC2 LOC103680386 LOC103680386 AKT1 AKT1 LOC103680441 LOC103680441 STAT3 STAT3 ADCY5 ADCY5 GSK3B GSK3B IKBKB IKBKB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6. (189 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (300 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
BAXApoptosis regulator BAX. (221 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CALML6Calmodulin-like protein 6. (180 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (368 aa)
LOC103663361Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
IL10RAInterleukin-10 receptor subunit alpha. (575 aa)
LOC103670936Neuroendocrine secretory protein 55. (247 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
IRF3Interferon regulatory factor 3 isoform X2. (421 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (54 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1360 aa)
KRASGTPase KRas isoform X3. (189 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2714 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
SRCTyrosine-protein kinase. (618 aa)
CTNNB1Catenin beta-1. (787 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (378 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
CCR3C-C chemokine receptor type 3 isoform X1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
PPP3CCSerine/threonine-protein phosphatase. (525 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
HRASGTPase HRas isoform X1. (189 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (179 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CALRCalreticulin. (417 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (150 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
FADDFAS-associated death domain protein. (192 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (358 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CCND1G1/S-specific cyclin-D1. (74 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1272 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (294 aa)
TNFRSF1ALOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1205 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4 isoform X1. (340 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PDIA3Protein disulfide-isomerase. (458 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (331 aa)
LOC103672268Class I histocompatibility antigen, Gogo-OKO alpha chain-like; Belongs to the MHC class I family. (351 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
EGFRReceptor protein-tyrosine kinase. (1191 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (109 aa)
E2F3Transcription factor E2F3. (224 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
LOC103656357H-2 class I histocompatibility antigen, Q10 alpha chain-like; Belongs to the MHC class I family. (418 aa)
CRKAdapter molecule crk. (287 aa)
MAPK14Mitogen-activated protein kinase. (362 aa)
SP1Sp1 transcription factor. (780 aa)
RELATranscription factor p65. (585 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (654 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
CALML4Calmodulin-like protein 4 isoform X1. (121 aa)
CALML5Calmodulin-like protein 5. (149 aa)
LOC103665481Putative Bcl-2 homologous antagonist/killer 2. (349 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MB21D1Cyclic GMP-AMP synthase. (209 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
TAP1Antigen peptide transporter 1. (621 aa)
TAP2Antigen peptide transporter 2 isoform X1. (703 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (563 aa)
E2F2Transcription factor E2F2. (443 aa)
SOS1Son of sevenless homolog 1. (1276 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (332 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PTGER2Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (408 aa)
ENSUMAP00000020007Guanine nucleotide-binding protein G(s) subunit alpha. (68 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CREB3L1LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 1. (501 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (482 aa)
CCL2C-C motif chemokine. (101 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
STING1Stimulator of interferon genes protein. (378 aa)
LOC103662147Interferon alpha-1/2-like. (197 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CXCL12Stromal cell-derived factor 1; Belongs to the intercrine alpha (chemokine CxC) family. (148 aa)
TSC1Hamartin. (1168 aa)
CCL5C-C motif chemokine. (91 aa)
CCL4C-C motif chemokine. (83 aa)
LOC103667299Regakine-1-like. (93 aa)
LOC103667298C-C motif chemokine. (93 aa)
CCL3L3C-C motif chemokine. (93 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
RB1Retinoblastoma-associated protein. (920 aa)
ITGAVLOW QUALITY PROTEIN: integrin alpha-V; Belongs to the integrin alpha chain family. (1056 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
CDK6Cyclin-dependent kinase 6. (278 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1067 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (383 aa)
LOC103662893C-X-C chemokine receptor type 2. (282 aa)
LOC103662772LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (321 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (104 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
LOC103673110Uncharacterized protein LOC103673110 isoform X1. (699 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1092 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
IL1R1Interleukin-1 receptor type 1 isoform X1. (572 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1034 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (582 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (412 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (413 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1163 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1274 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
RHOARas homolog family member A. (193 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1034 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (787 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (324 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1526 aa)
GNG8Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8. (71 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X3. (2738 aa)
E2F1Transcription factor E2F1. (401 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (206 aa)
LOC103680386Interferon alpha-1/2-like. (187 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
LOC103680441DLA class I histocompatibility antigen, A9/A9 alpha chain-like; Belongs to the MHC class I family. (381 aa)
STAT3Signal transducer and activator of transcription. (838 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1038 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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