STRINGSTRING
PTK2B PTK2B TCEB2 TCEB2 BCL2L1 BCL2L1 AP1M1 AP1M1 BAX BAX CYCS CYCS CALML6 CALML6 GNB1 GNB1 CHEK1 CHEK1 LOC103663361 LOC103663361 CD3G CD3G CD3D CD3D CD3E CD3E PLCG1 PLCG1 IRF3 IRF3 GNG5 GNG5 BAD BAD PAK2 PAK2 KRAS KRAS ITPR2 ITPR2 MAPK1 MAPK1 CRKL CRKL SAMHD1 SAMHD1 TLR4 TLR4 CCNB3 CCNB3 CCR5 CCR5 MAP2K3 MAP2K3 GNB3 GNB3 PPP3CC PPP3CC CD4 CD4 PPP3CA PPP3CA NFKB1 NFKB1 HRAS HRAS MYD88 MYD88 CXCR4 CXCR4 CALR CALR CALM1 CALM1 GNG7 GNG7 CDK1 CDK1 FADD FADD GNG4 GNG4 TNFRSF1A TNFRSF1A GNB4 GNB4 PAK5 PAK5 MAP2K6 MAP2K6 B2M B2M FOS FOS PIK3CA PIK3CA CCNB1 CCNB1 PIK3R1 PIK3R1 PDIA3 PDIA3 ATM ATM LOC103672268 LOC103672268 CUL5 CUL5 AP1S2 AP1S2 PIK3R2 PIK3R2 PPP3CB PPP3CB LOC103656357 LOC103656357 CRK CRK MAPK14 MAPK14 RELA RELA CFL1 CFL1 GNB2 GNB2 MAPK3 MAPK3 NFKBIA NFKBIA PRKCG PRKCG PAK1 PAK1 AP1S1 AP1S1 BID BID CFL2 CFL2 CUL1 CUL1 NRAS NRAS BST2 BST2 DDB1 DDB1 AKT3 AKT3 CALML4 CALML4 CALML5 CALML5 LOC103665481 LOC103665481 MAP2K1 MAP2K1 MB21D1 MB21D1 FAS FAS MAP3K7 MAP3K7 TAP1 TAP1 TAP2 TAP2 RPS6KB2 RPS6KB2 WEE1 WEE1 GNAI3 GNAI3 ATR ATR CASP3 CASP3 RNF7 RNF7 GNG2 GNG2 GNAI1 GNAI1 TAB1 TAB1 APOBEC3F APOBEC3F LOC103681381 LOC103681381 GNG3 GNG3 PIK3CB PIK3CB WEE2 WEE2 TNF TNF PLCG2 PLCG2 MAPK8 MAPK8 GNGT2 GNGT2 STING1 STING1 LIMK2 LIMK2 LOC103662147 LOC103662147 AP1B1 AP1B1 TLR2 TLR2 CD247 CD247 LOC103656543 LOC103656543 TRAF6 TRAF6 RAF1 RAF1 SKP1 SKP1 AP1S3 AP1S3 AP1G1 AP1G1 RIPK1 RIPK1 ELOC ELOC NFATC3 NFATC3 IKBKG IKBKG AKT2 AKT2 GNB5 GNB5 GNGT1 GNGT1 GNG11 GNG11 FASLG FASLG PTK2 PTK2 TRADD TRADD TBK1 TBK1 PRKCA PRKCA TRAF5 TRAF5 PPP3R1 PPP3R1 GNG13 GNG13 CUL4A CUL4A CASP8 CASP8 CASP9 CASP9 RBX1 RBX1 DCAF1 DCAF1 TNFRSF1B TNFRSF1B RPS6KB1 RPS6KB1 CHUK CHUK CUL4B CUL4B NFATC4 NFATC4 BTRC BTRC GNAQ GNAQ MTOR MTOR GNG8 GNG8 PIK3R3 PIK3R3 CCNB2 CCNB2 ITPR1 ITPR1 IRAK4 IRAK4 NFATC2 NFATC2 MAPK9 MAPK9 FBXW11 FBXW11 LOC103680386 LOC103680386 AKT1 AKT1 LOC103680441 LOC103680441 MAPK10 MAPK10 AP1M2 AP1M2 IKBKB IKBKB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
TCEB2Transcription elongation factor B polypeptide 2. (180 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
BAXApoptosis regulator BAX. (221 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CALML6Calmodulin-like protein 6. (180 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (368 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (497 aa)
LOC103663361Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (182 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
PLCG1Phosphoinositide phospholipase C. (1178 aa)
IRF3Interferon regulatory factor 3 isoform X2. (421 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (54 aa)
BADBcl2-associated agonist of cell death. (168 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
KRASGTPase KRas isoform X3. (189 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2714 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1332 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
PPP3CCSerine/threonine-protein phosphatase. (525 aa)
CD4T-cell surface glycoprotein CD4. (460 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
HRASGTPase HRas isoform X1. (189 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CALRCalreticulin. (417 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
FADDFAS-associated death domain protein. (192 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
TNFRSF1ALOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4 isoform X1. (340 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
CCNB1LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (413 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PDIA3Protein disulfide-isomerase. (458 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
LOC103672268Class I histocompatibility antigen, Gogo-OKO alpha chain-like; Belongs to the MHC class I family. (351 aa)
CUL5Cullin-5; Belongs to the cullin family. (759 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
LOC103656357H-2 class I histocompatibility antigen, Q10 alpha chain-like; Belongs to the MHC class I family. (418 aa)
CRKAdapter molecule crk. (287 aa)
MAPK14Mitogen-activated protein kinase. (362 aa)
RELATranscription factor p65. (585 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (654 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (149 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BST2Bone marrow stromal antigen 2. (259 aa)
DDB1DNA damage-binding protein 1. (1098 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
CALML4Calmodulin-like protein 4 isoform X1. (121 aa)
CALML5Calmodulin-like protein 5. (149 aa)
LOC103665481Putative Bcl-2 homologous antagonist/killer 2. (349 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MB21D1Cyclic GMP-AMP synthase. (209 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TAP1Antigen peptide transporter 1. (621 aa)
TAP2Antigen peptide transporter 2 isoform X1. (703 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (563 aa)
WEE1Wee1-like protein kinase. (522 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2637 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
RNF7RING-box protein 2. (108 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (332 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (498 aa)
APOBEC3FDNA dC->dU-editing enzyme APOBEC-3F. (211 aa)
LOC103681381DNA dC->dU-editing enzyme APOBEC-3G-like isoform X1. (198 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
WEE2Wee1-like protein kinase. (557 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1191 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
STING1Stimulator of interferon genes protein. (378 aa)
LIMK2LIM domain kinase 2 isoform X2. (706 aa)
LOC103662147Interferon alpha-1/2-like. (197 aa)
AP1B1AP complex subunit beta. (946 aa)
TLR2LOW QUALITY PROTEIN: toll-like receptor 2; Belongs to the Toll-like receptor family. (743 aa)
CD247T-cell surface glycoprotein CD3 zeta chain isoform X1. (257 aa)
LOC103656543AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (151 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (153 aa)
AP1G1AP-1 complex subunit gamma. (822 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
ELOCTranscription elongation factor B polypeptide 1; Belongs to the SKP1 family. (112 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1067 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (383 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (104 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1092 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (582 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
CUL4Acullin-4A; Belongs to the cullin family. (856 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (413 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (123 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1529 aa)
TNFRSF1BLOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B. (313 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
CUL4BLOW QUALITY PROTEIN: cullin-4B; Belongs to the cullin family. (895 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (787 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (324 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
GNG8Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8. (71 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (397 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X3. (2738 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (206 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X1. (510 aa)
LOC103680386Interferon alpha-1/2-like. (187 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
LOC103680441DLA class I histocompatibility antigen, A9/A9 alpha chain-like; Belongs to the MHC class I family. (381 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
AP1M2AP-1 complex subunit mu-2 isoform X1; Belongs to the adaptor complexes medium subunit family. (484 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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