STRINGSTRING
ERG ERG LEF1 LEF1 EGF EGF CREB5 CREB5 CDKN1B CDKN1B HSP90AA1 HSP90AA1 CREBBP CREBBP BAD BAD KRAS KRAS MAPK1 MAPK1 PDGFRA PDGFRA CTNNB1 CTNNB1 FGFR2 FGFR2 PDGFRB PDGFRB ETV5 ETV5 NFKB1 NFKB1 HSP90AB1 HSP90AB1 PDGFA PDGFA HRAS HRAS TCF7L1 TCF7L1 CREB3 CREB3 CCND1 CCND1 SOS2 SOS2 PIK3CA PIK3CA PIK3R1 PIK3R1 GRB2 GRB2 PDGFD PDGFD EGFR EGFR LOC103662452 LOC103662452 LOC103662454 LOC103662454 FGFR1 FGFR1 E2F3 E2F3 PIK3R2 PIK3R2 RELA RELA MAPK3 MAPK3 NFKBIA NFKBIA NRAS NRAS AKT3 AKT3 MAP2K1 MAP2K1 PTEN PTEN SPINT1 SPINT1 PLAU PLAU LOC103679521 LOC103679521 LOC103679616 LOC103679616 E2F2 E2F2 SOS1 SOS1 CCNE1 CCNE1 ATF4 ATF4 PIK3CB PIK3CB BRAF BRAF CREB3L1 CREB3L1 ZEB1 ZEB1 CREB3L2 CREB3L2 CDK2 CDK2 PDGFC PDGFC CCNE2 CCNE2 TP53 TP53 ERBB2 ERBB2 RAF1 RAF1 TCF7 TCF7 RB1 RB1 HSP90B1 HSP90B1 IGF1 IGF1 IKBKG IKBKG FOXO1 FOXO1 AKT2 AKT2 SRD5A2 SRD5A2 CREB3L4 CREB3L4 MDM2 MDM2 IL1R2 IL1R2 TGFA TGFA EP300 EP300 CASP9 CASP9 CREB1 CREB1 CHUK CHUK PDPK1 PDPK1 MTOR MTOR PIK3R3 PIK3R3 E2F1 E2F1 AKT1 AKT1 GSK3B GSK3B IKBKB IKBKB PLAT PLAT TMPRSS2 TMPRSS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERGTranscriptional regulator ERG isoform X1. (486 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X2. (450 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1159 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (185 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
CREBBPCREB-binding protein. (1954 aa)
BADBcl2-associated agonist of cell death. (168 aa)
KRASGTPase KRas isoform X3. (189 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CTNNB1Catenin beta-1. (787 aa)
FGFR2Fibroblast growth factor receptor. (602 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1152 aa)
ETV5LOW QUALITY PROTEIN: ETS translocation variant 5. (496 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
HSP90AB1Heat shock protein HSP 90-beta. (699 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (288 aa)
HRASGTPase HRas isoform X1. (189 aa)
TCF7L1Transcription factor 7-like 1. (535 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (358 aa)
CCND1G1/S-specific cyclin-D1. (74 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1272 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PDGFDPlatelet-derived growth factor D. (365 aa)
EGFRReceptor protein-tyrosine kinase. (1191 aa)
LOC103662452Stromelysin-1. (459 aa)
LOC103662454Stromelysin-1-like. (470 aa)
FGFR1Fibroblast growth factor receptor. (788 aa)
E2F3Transcription factor E2F3. (224 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
RELATranscription factor p65. (585 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
SPINT1Kunitz-type protease inhibitor 1. (501 aa)
PLAUUrokinase-type plasminogen activator; Belongs to the peptidase S1 family. (432 aa)
LOC103679521Glutathione S-transferase P-like; Belongs to the GST superfamily. (220 aa)
LOC103679616Glutathione S-transferase P-like; Belongs to the GST superfamily. (157 aa)
E2F2Transcription factor E2F2. (443 aa)
SOS1Son of sevenless homolog 1. (1276 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (407 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
BRAFSerine/threonine-protein kinase B-raf. (715 aa)
CREB3L1LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 1. (501 aa)
ZEB1Zinc finger E-box-binding homeobox 1. (1086 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ERBB2Receptor protein-tyrosine kinase. (1248 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
TCF7Transcription factor 7 isoform X4. (316 aa)
RB1Retinoblastoma-associated protein. (920 aa)
HSP90B1Endoplasmin. (350 aa)
IGF1Insulin-like growth factor I isoform X1. (184 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
FOXO1Forkhead box protein O1. (432 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase 2 isoform X1. (135 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
IL1R2Interleukin-1 receptor type 2 isoform X1. (413 aa)
TGFAProtransforming growth factor alpha. (92 aa)
EP300LOW QUALITY PROTEIN: histone acetyltransferase p300. (2390 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (413 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (572 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
E2F1Transcription factor E2F1. (401 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
TMPRSS2Transmembrane protease serine 2 isoform X1; Belongs to the peptidase S1 family. (510 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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