STRINGSTRING
CALML6 CALML6 CAV2 CAV2 CAV1 CAV1 HSP90AA1 HSP90AA1 MMP2 MMP2 MGST1 MGST1 LOC103669208 LOC103669208 LOC103669209 LOC103669209 LOC103669212 LOC103669212 SRC SRC GSTA4 GSTA4 LOC103664000 LOC103664000 LOC103663999 LOC103663999 LOC103664001 LOC103664001 LOC103664002 LOC103664002 CTNNB1 CTNNB1 BMPR1B BMPR1B NFKB1 NFKB1 HSP90AB1 HSP90AB1 ACVR2B ACVR2B PDGFA PDGFA ACVR1 ACVR1 VEGFA VEGFA KDR KDR MAPK7 MAPK7 CALM1 CALM1 ACVR2A ACVR2A TNFRSF1A TNFRSF1A PRKAA1 PRKAA1 MAP2K6 MAP2K6 FOS FOS PIK3CA PIK3CA VCAM1 VCAM1 PIK3R1 PIK3R1 LOC103682229 LOC103682229 LOC103682209 LOC103682209 IL1B IL1B IL1A IL1A PIK3R2 PIK3R2 CTSV CTSV MAPK14 MAPK14 PRKCZ PRKCZ RELA RELA AKT3 AKT3 CALML4 CALML4 CALML5 CALML5 NOX1 NOX1 MAP3K7 MAP3K7 LOC103679521 LOC103679521 LOC103679616 LOC103679616 LOC103675003 LOC103675003 LOC103675005 LOC103675005 GSTM3 GSTM3 ITGA2B ITGA2B BMPR1A BMPR1A PIK3CB PIK3CB NCF1 NCF1 MGST2 MGST2 TNF TNF ACTG1 ACTG1 CCL2 CCL2 MAPK8 MAPK8 NFE2L2 NFE2L2 NPPC NPPC BMP4 BMP4 ITGB3 ITGB3 NCF2 NCF2 SDC2 SDC2 TP53 TP53 LOC103678564 LOC103678564 SELE SELE PECAM1 PECAM1 EDN1 EDN1 NQO1 NQO1 ITGAV ITGAV HSP90B1 HSP90B1 ASS1 ASS1 IKBKG IKBKG CAV3 CAV3 AKT2 AKT2 PTK2 PTK2 IFNG IFNG IL1R1 IL1R1 IL1R2 IL1R2 CDH5 CDH5 MAP2K4 MAP2K4 SUMO1-2 SUMO1-2 BMPR2 BMPR2 PRKAA2 PRKAA2 MGST3 MGST3 CHUK CHUK RHOA RHOA SDC1 SDC1 GSTO1 GSTO1 GSTO2 GSTO2 PIK3R3 PIK3R3 MAP3K5 MAP3K5 SQSTM1 SQSTM1 DUSP1 DUSP1 MAPK9 MAPK9 AKT1 AKT1 MAPK10 MAPK10 KEAP1 KEAP1 ICAM1 ICAM1 SDC4 SDC4 SUMO3 SUMO3 IKBKB IKBKB PLAT PLAT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALML6Calmodulin-like protein 6. (180 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (106 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
MMP272 kDa type IV collagenase. (652 aa)
MGST1Microsomal Glutathione S-transferase 1. (155 aa)
LOC103669208Glutathione S-transferase theta-1-like. (242 aa)
LOC103669209Glutathione S-transferase theta-1 isoform X1. (240 aa)
LOC103669212Glutathione S-transferase theta-2B-like; Belongs to the GST superfamily. (243 aa)
SRCTyrosine-protein kinase. (618 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (223 aa)
LOC103664000Glutathione S-transferase A4-like; Belongs to the GST superfamily. (222 aa)
LOC103663999Glutathione S-transferase A2-like. (220 aa)
LOC103664001Glutathione S-transferase. (223 aa)
LOC103664002Glutathione S-transferase-like. (238 aa)
CTNNB1Catenin beta-1. (787 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
HSP90AB1Heat shock protein HSP 90-beta. (699 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (303 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (288 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (179 aa)
KDRLOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (264 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
TNFRSF1ALOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
PRKAA1Non-specific serine/threonine protein kinase. (500 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
VCAM1Vascular cell adhesion protein 1 isoform X1. (748 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC103682229Cathepsin L1-like; Belongs to the peptidase C1 family. (372 aa)
LOC103682209Cathepsin L1-like; Belongs to the peptidase C1 family. (333 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (331 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (244 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
CTSVCathepsin L2; Belongs to the peptidase C1 family. (335 aa)
MAPK14Mitogen-activated protein kinase. (362 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
RELATranscription factor p65. (585 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
CALML4Calmodulin-like protein 4 isoform X1. (121 aa)
CALML5Calmodulin-like protein 5. (149 aa)
NOX1NADPH oxidase 1 isoform X1. (568 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LOC103679521Glutathione S-transferase P-like; Belongs to the GST superfamily. (220 aa)
LOC103679616Glutathione S-transferase P-like; Belongs to the GST superfamily. (157 aa)
LOC103675003Glutathione S-transferase Mu 1 isoform X3; Belongs to the GST superfamily. (218 aa)
LOC103675005Glutathione S-transferase Mu 1; Belongs to the GST superfamily. (218 aa)
GSTM3Glutathione S-transferase. (226 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1086 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
NCF1Neutrophil cytosol factor 1. (389 aa)
MGST2Microsomal glutathione S-transferase 2 isoform X1. (174 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ACTG1LOW QUALITY PROTEIN: actin, cytoplasmic 2. (375 aa)
CCL2C-C motif chemokine. (101 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X2. (590 aa)
NPPCC-type natriuretic peptide. (74 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
NCF2Neutrophil cytosol factor 2. (525 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (186 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LOC103678564Thioredoxin; Belongs to the thioredoxin family. (106 aa)
SELEE-selectin. (607 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (765 aa)
EDN1Endothelin-1. (202 aa)
NQO1NAD(P)H dehydrogenase [quinone] 1. (253 aa)
ITGAVLOW QUALITY PROTEIN: integrin alpha-V; Belongs to the integrin alpha chain family. (1056 aa)
HSP90B1Endoplasmin. (350 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1092 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL1R1Interleukin-1 receptor type 1 isoform X1. (572 aa)
IL1R2Interleukin-1 receptor type 2 isoform X1. (413 aa)
CDH5LOW QUALITY PROTEIN: cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (720 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
SUMO1-2Small ubiquitin-related modifier. (62 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PRKAA2Non-specific serine/threonine protein kinase. (390 aa)
MGST3Microsomal glutathione S-transferase 3 isoform X1. (199 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
RHOARas homolog family member A. (193 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (68 aa)
GSTO1Glutathione S-transferase omega-1; Belongs to the GST superfamily. (225 aa)
GSTO2Glutathione S-transferase omega-2; Belongs to the GST superfamily. (238 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1768 aa)
SQSTM1Sequestosome-1. (391 aa)
DUSP1Dual specificity protein phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (225 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
KEAP1Kelch-like ECH-associated protein 1. (579 aa)
ICAM1Intercellular adhesion molecule 1. (331 aa)
SDC4Syndecan-4. (255 aa)
SUMO3Small ubiquitin-related modifier 3. (240 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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