(17 nodes) Mixed, incl. Tetrahydrobiopterin metabolic process, and ACT domain network (Neomonachus schauinslandi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC110570001	Carbonyl reductase [NADPH] 3 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	LOC110570003	Carbonyl reductase [NADPH] 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	TPH2	Tryptophan 5-hydroxylase 2 isoform X1. (497 aa)
	QDPR	Dihydropteridine reductase isoform X1. (242 aa)
	LOC110572461	Carbonyl reductase [NADPH] 2-like. (244 aa)
	DHDH	LOW QUALITY PROTEIN: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. (335 aa)
	TPH1	Tryptophan 5-hydroxylase 1. (444 aa)
	PAH	Phenylalanine-4-hydroxylase. (451 aa)
	AKR1B1	Aldose reductase. (316 aa)
	GCHFR	GTP cyclohydrolase 1 feedback regulatory protein. (84 aa)
	PTS	6-pyruvoyl tetrahydrobiopterin synthase. (147 aa)
	AKR1E2	1,5-anhydro-D-fructose reductase isoform X1. (301 aa)
	LCT	Lactase-phlorizin hydrolase. (1924 aa)
	SPR	Sepiapterin reductase. (267 aa)
	PCBD1	Pterin-4-alpha-carbinolamine dehydratase. (104 aa)
	GCH1	GTP cyclohydrolase 1 isoform X1. (249 aa)
	PCBD2	Pterin-4-alpha-carbinolamine dehydratase 2. (130 aa)

Your Current Organism:

Neomonachus schauinslandi

NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1B1	DHDH	A0A2Y9HFK0	A0A2Y9GCX7	Aldose reductase.	LOW QUALITY PROTEIN: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.	0.915
AKR1B1	LCT	A0A2Y9HFK0	A0A2Y9HQ07	Aldose reductase.	Lactase-phlorizin hydrolase.	0.904
AKR1B1	LOC110570001	A0A2Y9HFK0	A0A2Y9G3M5	Aldose reductase.	Carbonyl reductase [NADPH] 3 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.798
AKR1B1	LOC110570003	A0A2Y9HFK0	A0A2Y9G469	Aldose reductase.	Carbonyl reductase [NADPH] 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.835
AKR1B1	LOC110572461	A0A2Y9HFK0	A0A2Y9GBT2	Aldose reductase.	Carbonyl reductase [NADPH] 2-like.	0.812
AKR1B1	PAH	A0A2Y9HFK0	A0A2Y9GVI7	Aldose reductase.	Phenylalanine-4-hydroxylase.	0.903
AKR1B1	PTS	A0A2Y9HFK0	A0A2Y9HKR9	Aldose reductase.	6-pyruvoyl tetrahydrobiopterin synthase.	0.900
AKR1B1	QDPR	A0A2Y9HFK0	A0A2Y9G7V7	Aldose reductase.	Dihydropteridine reductase isoform X1.	0.915
AKR1B1	SPR	A0A2Y9HFK0	A0A2Y9HTH7	Aldose reductase.	Sepiapterin reductase.	0.911
AKR1B1	TPH1	A0A2Y9HFK0	A0A2Y9GQE3	Aldose reductase.	Tryptophan 5-hydroxylase 1.	0.900
AKR1B1	TPH2	A0A2Y9HFK0	A0A2Y9G5E4	Aldose reductase.	Tryptophan 5-hydroxylase 2 isoform X1.	0.900
AKR1E2	DHDH	A0A2Y9HL64	A0A2Y9GCX7	1,5-anhydro-D-fructose reductase isoform X1.	LOW QUALITY PROTEIN: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.	0.822
AKR1E2	LCT	A0A2Y9HL64	A0A2Y9HQ07	1,5-anhydro-D-fructose reductase isoform X1.	Lactase-phlorizin hydrolase.	0.799
AKR1E2	LOC110570001	A0A2Y9HL64	A0A2Y9G3M5	1,5-anhydro-D-fructose reductase isoform X1.	Carbonyl reductase [NADPH] 3 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.798
AKR1E2	LOC110570003	A0A2Y9HL64	A0A2Y9G469	1,5-anhydro-D-fructose reductase isoform X1.	Carbonyl reductase [NADPH] 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.798
AKR1E2	LOC110572461	A0A2Y9HL64	A0A2Y9GBT2	1,5-anhydro-D-fructose reductase isoform X1.	Carbonyl reductase [NADPH] 2-like.	0.796
AKR1E2	PAH	A0A2Y9HL64	A0A2Y9GVI7	1,5-anhydro-D-fructose reductase isoform X1.	Phenylalanine-4-hydroxylase.	0.797
AKR1E2	PTS	A0A2Y9HL64	A0A2Y9HKR9	1,5-anhydro-D-fructose reductase isoform X1.	6-pyruvoyl tetrahydrobiopterin synthase.	0.791
AKR1E2	QDPR	A0A2Y9HL64	A0A2Y9G7V7	1,5-anhydro-D-fructose reductase isoform X1.	Dihydropteridine reductase isoform X1.	0.823
AKR1E2	SPR	A0A2Y9HL64	A0A2Y9HTH7	1,5-anhydro-D-fructose reductase isoform X1.	Sepiapterin reductase.	0.815