(36 nodes) SMAD protein signal transduction, and Activin binding network (Neomonachus schauinslandi)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	SMURF2	E3 ubiquitin-protein ligase. (736 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	SMAD9	Mothers against decapentaplegic homolog. (469 aa)
	TGFB3	Transforming growth factor beta-3. (461 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
	SMURF1	E3 ubiquitin-protein ligase. (731 aa)
	LOC110571365	Left-right determination factor. (364 aa)
	SKI	Ski oncogene isoform X1. (731 aa)
	ZFYVE9	Zinc finger FYVE domain-containing protein. (1423 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	LTBP3	Latent-transforming growth factor beta-binding protein 3 isoform X1. (1298 aa)
	INHBC	Inhibin beta C chain. (352 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	GDF11	Growth/differentiation factor 11. (376 aa)
	INHBE	Inhibin beta E chain. (351 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	LOC110583310	Mothers against decapentaplegic homolog. (451 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	SMAD6	Mothers against decapentaplegic homolog. (498 aa)
	LTBP1	Latent-transforming growth factor beta-binding protein 1. (1393 aa)
	INHBB	Inhibin beta B chain. (407 aa)
	FST	Follistatin isoform X1. (344 aa)
	ZFYVE16	Zinc finger FYVE domain-containing protein 16. (1540 aa)
	NODAL	Nodal homolog. (348 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	SKIL	Ski-like protein isoform X1. (684 aa)
	MSTN	Growth/differentiation factor 8. (375 aa)
	INHA	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
	INHBA	Inhibin beta A chain. (424 aa)
	ACVR1B	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
	FSTL3	Follistatin-related protein 3. (262 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (443 aa)
	ACVR2B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)

Your Current Organism:

Neomonachus schauinslandi

NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1B	ACVR1C	A0A2Y9I952	A0A2Y9IBD0	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.935
ACVR1B	ACVR2B	A0A2Y9I952	A0A2Y9ICY5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.973
ACVR1B	FST	A0A2Y9I952	A0A2Y9HSX5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Follistatin isoform X1.	0.567
ACVR1B	GDF11	A0A2Y9I952	A0A2Y9GYL5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Growth/differentiation factor 11.	0.972
ACVR1B	INHA	A0A2Y9I952	A0A2Y9I4G4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family.	0.448
ACVR1B	INHBA	A0A2Y9I952	A0A2Y9I6R3	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Inhibin beta A chain.	0.993
ACVR1B	INHBB	A0A2Y9I952	A0A2Y9HPD6	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Inhibin beta B chain.	0.957
ACVR1B	INHBC	A0A2Y9I952	A0A2Y9GUR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Inhibin beta C chain.	0.940
ACVR1B	INHBE	A0A2Y9I952	A0A2Y9H0G9	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Inhibin beta E chain.	0.877
ACVR1B	LOC110571365	A0A2Y9I952	A0A2Y9GAK8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Left-right determination factor.	0.406
ACVR1B	LOC110583310	A0A2Y9I952	A0A2Y9HI04	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.927
ACVR1B	MSTN	A0A2Y9I952	A0A2Y9I4C3	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Growth/differentiation factor 8.	0.975
ACVR1B	NODAL	A0A2Y9I952	A0A2Y9HVR5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Nodal homolog.	0.953
ACVR1B	SMAD1	A0A2Y9I952	A0A2Y9G7S1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.433
ACVR1B	SMAD2	A0A2Y9I952	A0A2Y9GVZ3	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.927
ACVR1B	SMAD3	A0A2Y9I952	A0A2Y9HII2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.974
ACVR1B	SMAD4	A0A2Y9I952	A0A2Y9GS17	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.790
ACVR1B	SMAD5	A0A2Y9I952	A0A2Y9I186	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.668
ACVR1B	SMAD6	A0A2Y9I952	A0A2Y9HJN0	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.803
ACVR1B	SMAD7	A0A2Y9I952	A0A2Y9GVZ8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.802