49 items (Neomonachus schauinslandi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APP	Amyloid beta A4 protein isoform X1. (770 aa)
	EPS15	Epidermal growth factor receptor substrate 15 isoform X1. (899 aa)
	AP1S3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (206 aa)
	SPHK1	Sphingosine kinase 1 isoform X1. (487 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (956 aa)
	LDLR	Low-density lipoprotein receptor. (861 aa)
	LRP2	LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 2. (4645 aa)
	DNM2	Dynamin-2 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	RAB35	Ras-related protein Rab-35. (221 aa)
	FCHSD2	F-BAR and double SH3 domains protein 2. (740 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	SGIP1	SH3-containing GRB2-like protein 3-interacting protein 1. (908 aa)
	NUMB	Protein numb homolog isoform X1. (653 aa)
	ITSN1	Intersectin-1. (1220 aa)
	INPP5F	Phosphatidylinositide phosphatase SAC2 isoform X2. (1138 aa)
	AAK1	AP2-associated protein kinase 1. (959 aa)
	CLHC1	Clathrin heavy chain linker domain-containing protein 1. (586 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (211 aa)
	STON1	Stonin-1; Belongs to the Stoned B family. (735 aa)
	AP2B1	AP complex subunit beta. (951 aa)
	FCHO2	LOW QUALITY PROTEIN: F-BAR domain only protein 2. (866 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
	EPN3	Epsin-3 isoform X1. (634 aa)
	ACKR3	Atypical chemokine receptor 3 isoform X1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	DGKD	Diacylglycerol kinase. (1111 aa)
	SH3BP4	SH3 domain-binding protein 4. (962 aa)
	HIP1R	Huntingtin-interacting protein 1-related protein isoform X1. (1068 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (944 aa)
	SLC18A3	Vesicular acetylcholine transporter. (517 aa)
	LOC110588744	Uncharacterized protein FLJ45252-like. (337 aa)
	ATAT1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (333 aa)
	ITSN2	Intersectin-2 isoform X1. (1657 aa)
	CUBN	Cubilin. (3620 aa)
	VLDLR	Very low-density lipoprotein receptor isoform X1. (845 aa)
	DAB2	Disabled homolog 2. (769 aa)
	REPS1	ralBP1-associated Eps domain-containing protein 1 isoform X1. (796 aa)
	TNK2	Activated CDC42 kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1057 aa)
	AP1S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	AP2M1	AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
	MYO6	LOW QUALITY PROTEIN: unconventional myosin-VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1262 aa)
	SNAP91	Clathrin coat assembly protein AP180. (899 aa)
	SORT1	Sortilin. (835 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (936 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (218 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1673 aa)
	DNM1L	Dynamin-1-like protein isoform X4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
	PICALM	Phosphatidylinositol-binding clathrin assembly protein isoform X1. (653 aa)
	EPS15L1	Epidermal growth factor receptor substrate 15-like 1 isoform X6. (910 aa)
	FCHO1	F-BAR domain only protein 1 isoform X1. (941 aa)

Your Current Organism:

Neomonachus schauinslandi

NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAK1	AP2A1	A0A2Y9I046	A0A2Y9GDF7	AP2-associated protein kinase 1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.515
AAK1	AP2B1	A0A2Y9I046	A0A2Y9I8G3	AP2-associated protein kinase 1.	AP complex subunit beta.	0.736
AAK1	AP2M1	A0A2Y9I046	A0A2Y9HFE9	AP2-associated protein kinase 1.	AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family.	0.798
AAK1	AP2S1	A0A2Y9I046	A0A2Y9GCW8	AP2-associated protein kinase 1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.637
AAK1	CLHC1	A0A2Y9I046	A0A2Y9HZB1	AP2-associated protein kinase 1.	Clathrin heavy chain linker domain-containing protein 1.	0.407
AAK1	CLTC	A0A2Y9I046	A0A2Y9I801	AP2-associated protein kinase 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.444
AAK1	CLTCL1	A0A2Y9I046	A0A2Y9H4J2	AP2-associated protein kinase 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.429
AAK1	EPS15	A0A2Y9I046	A0A2Y9GL71	AP2-associated protein kinase 1.	Epidermal growth factor receptor substrate 15 isoform X1.	0.719
AAK1	EPS15L1	A0A2Y9I046	A0A2Y9GLW8	AP2-associated protein kinase 1.	Epidermal growth factor receptor substrate 15-like 1 isoform X6.	0.657
AAK1	FCHO1	A0A2Y9I046	A0A2Y9GLU4	AP2-associated protein kinase 1.	F-BAR domain only protein 1 isoform X1.	0.438
AAK1	HIP1R	A0A2Y9I046	A0A2Y9HXS8	AP2-associated protein kinase 1.	Huntingtin-interacting protein 1-related protein isoform X1.	0.501
AAK1	ITSN2	A0A2Y9I046	A0A2Y9HNI3	AP2-associated protein kinase 1.	Intersectin-2 isoform X1.	0.598
AAK1	LOC110588744	A0A2Y9I046	A0A2Y9HTA2	AP2-associated protein kinase 1.	Uncharacterized protein FLJ45252-like.	0.787
AAK1	NUMB	A0A2Y9I046	A0A2Y9G8V6	AP2-associated protein kinase 1.	Protein numb homolog isoform X1.	0.588
AAK1	PICALM	A0A2Y9I046	A0A2Y9GS45	AP2-associated protein kinase 1.	Phosphatidylinositol-binding clathrin assembly protein isoform X1.	0.541
AAK1	REPS1	A0A2Y9I046	A0A2Y9HH77	AP2-associated protein kinase 1.	ralBP1-associated Eps domain-containing protein 1 isoform X1.	0.711
AAK1	SGIP1	A0A2Y9I046	A0A2Y9G9H1	AP2-associated protein kinase 1.	SH3-containing GRB2-like protein 3-interacting protein 1.	0.435
AAK1	SNAP91	A0A2Y9I046	A0A2Y9HAS6	AP2-associated protein kinase 1.	Clathrin coat assembly protein AP180.	0.541
AP1S1	AP1S3	A0A2Y9HFK7	A0A2Y9GHQ6	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.933
AP1S1	AP2A1	A0A2Y9HFK7	A0A2Y9GDF7	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.703