STRINGSTRING
PTPRJ PTPRJ ARL2 ARL2 AP1AR AP1AR MACF1 MACF1 PDPN PDPN COL16A1 COL16A1 RCC2 RCC2 EGFL6 EGFL6 ARHGAP6 ARHGAP6 MYOC MYOC ROCK1 ROCK1 AJAP1 AJAP1 ADAM15 ADAM15 PLEKHA2 PLEKHA2 FLNA FLNA TEK TEK ACER2 ACER2 MYADM MYADM CASK CASK P4HB P4HB JUP JUP SFRP1 SFRP1 NPNT NPNT RRAS RRAS FUT1 FUT1 TBCD TBCD CIB1 CIB1 LIMS1 LIMS1 CDC42 CDC42 TACSTD2 TACSTD2 ILK ILK WNT1 WNT1 SKAP1 SKAP1 CRK CRK EMID1 EMID1 CDH13 CDH13 VTN VTN CAMSAP3 CAMSAP3 PLEKHA1 PLEKHA1 FZD7 FZD7 ACVRL1 ACVRL1 NF1 NF1 SPOCK1 SPOCK1 FERMT2 FERMT2 CORO1C CORO1C VWC2 VWC2 ACTN4 ACTN4 FN1 FN1 FOXF1 FOXF1 PIK3R1 PIK3R1 SPRY4 SPRY4 SLK SLK LDB1 LDB1 RASA1 RASA1 LIMCH1 LIMCH1 RELL2 RELL2 SPOCK2 SPOCK2 KDR KDR EFNA5 EFNA5 PRKCE PRKCE RIN2 RIN2 COL26A1 COL26A1 VCL VCL EMP2 EMP2 EDIL3 EDIL3 PLAU PLAU WDPCP WDPCP PTK2B PTK2B DMTN DMTN CARMIL1 CARMIL1 CCL28 CCL28 PTEN PTEN LIMS2 LIMS2 VIT VIT EMILIN1 EMILIN1 ITGB1BP1 ITGB1BP1 RREB1 RREB1 NEDD9 NEDD9 C1QBP C1QBP DDR1 DDR1 RSU1 RSU1 LOC110584449 LOC110584449 CD3E CD3E THY1 THY1 NID1 NID1 THBS1 THBS1 GREM1 GREM1 EPHA1 EPHA1 EGFLAM EGFLAM FBLN2 FBLN2 HRG HRG PHLDB2 PHLDB2 ECM2 ECM2 CCDC80 CCDC80 KANK1 KANK1 ANGPT2 ANGPT2 LOC110584033 LOC110584033 CORO2B CORO2B VEGFA VEGFA LOC110581667 LOC110581667 LRRC45 LRRC45 LOC110583085 LOC110583085 CORO2A CORO2A NOTCH1 NOTCH1 BCL6 BCL6 BRAF BRAF GSK3B GSK3B MELTF MELTF CYR61 CYR61 APOD APOD ABI3BP ABI3BP COL8A1 COL8A1 LOC110581921 LOC110581921 TSC1 TSC1 ABL1 ABL1 TESK1 TESK1 CCL21 CCL21 BST1 BST1 CSF1 CSF1 MYF5 MYF5 AGR2 AGR2 SEMA3E SEMA3E CDK6 CDK6 HOXA7 HOXA7 LOC110577927 LOC110577927 S100A10 S100A10 FBLN1 FBLN1 FERMT1 FERMT1 PTPRA PTPRA JAG1 JAG1 RAC2 RAC2 STK4 STK4 ONECUT2 ONECUT2 CRKL CRKL PREX1 PREX1 PPM1F PPM1F LOC110578202 LOC110578202 NRP1 NRP1 NEXMIF NEXMIF HSD17B12 HSD17B12 FZD4 FZD4 EFEMP2 EFEMP2 PIK3CB PIK3CB CASS4 CASS4 ITGB3 ITGB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPRJReceptor-type tyrosine-protein phosphatase eta. (1089 aa)
ARL2ADP-ribosylation factor-like protein 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
AP1ARAP-1 complex-associated regulatory protein. (302 aa)
MACF1Microtubule-actin cross-linking factor 1. (5418 aa)
PDPNPodoplanin. (142 aa)
COL16A1Collagen alpha-1(XVI) chain isoform X1. (1625 aa)
RCC2Protein RCC2. (292 aa)
EGFL6Epidermal growth factor-like protein 6. (398 aa)
ARHGAP6LOW QUALITY PROTEIN: rho GTPase-activating protein 6. (981 aa)
MYOCMyocilin. (490 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
AJAP1Adherens junction-associated protein 1. (401 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (893 aa)
PLEKHA2Pleckstrin homology domain-containing family A member 2. (425 aa)
FLNAfilamin-A. (2592 aa)
TEKAngiopoietin-1 receptor. (1124 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
MYADMMyeloid-associated differentiation marker. (322 aa)
CASKPeripheral plasma membrane protein CASK; Belongs to the MAGUK family. (853 aa)
P4HBProtein disulfide-isomerase. (510 aa)
JUPJunction plakoglobin. (744 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
NPNTNephronectin isoform X1. (597 aa)
RRASRas-related protein R-Ras isoform X1. (218 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (411 aa)
TBCDTubulin-specific chaperone D isoform X1. (1218 aa)
CIB1Calcium and integrin-binding protein 1 isoform X1. (215 aa)
LIMS1LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (387 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
TACSTD2Tumor-associated calcium signal transducer 2. (323 aa)
ILKIntegrin-linked protein kinase isoform X1. (452 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SKAP1Src kinase-associated phosphoprotein 1. (363 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
EMID1EMI domain-containing protein 1. (423 aa)
CDH13Cadherin-13. (713 aa)
VTNVitronectin. (471 aa)
CAMSAP3Calmodulin-regulated spectrin-associated protein 3. (1088 aa)
PLEKHA1Pleckstrin homology domain-containing family A member 1 isoform X1. (409 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
NF1Neurofibromin isoform X1. (2841 aa)
SPOCK1Testican-1. (439 aa)
FERMT2Fermitin family homolog 2. (680 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
VWC2Brorin. (324 aa)
ACTN4Alpha-actinin-4. (911 aa)
FN1Fibronectin isoform X7. (2476 aa)
FOXF1Forkhead box protein F1. (384 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
SPRY4Protein sprouty homolog 4. (299 aa)
SLKSTE20-like serine/threonine-protein kinase isoform X1. (1241 aa)
LDB1LIM domain-binding protein 1 isoform X1. (411 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1039 aa)
LIMCH1LIM and calponin homology domains-containing protein 1. (1465 aa)
RELL2RELT-like protein 2. (294 aa)
SPOCK2Testican-2 isoform X1. (424 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
RIN2Ras and Rab interactor 2 isoform X1. (896 aa)
COL26A1Collagen alpha-1(XXVI) chain. (442 aa)
VCLVinculin isoform X2. (1134 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
EDIL3EGF-like repeat and discoidin I-like domain-containing protein 3 isoform X1. (480 aa)
PLAUUrokinase-type plasminogen activator. (432 aa)
WDPCPWD repeat-containing and planar cell polarity effector protein fritz homolog. (714 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1010 aa)
DMTNDematin. (405 aa)
CARMIL1F-actin-uncapping protein LRRC16A. (1373 aa)
CCL28C-C motif chemokine. (127 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (341 aa)
VITVitrin. (720 aa)
EMILIN1EMILIN-1. (1013 aa)
ITGB1BP1Integrin beta-1-binding protein 1. (200 aa)
RREB1Ras-responsive element-binding protein 1. (1768 aa)
NEDD9Enhancer of filamentation 1. (834 aa)
C1QBPComplement component 1 Q subcomponent-binding protein, mitochondrial. (272 aa)
DDR1LOW QUALITY PROTEIN: epithelial discoidin domain-containing receptor 1. (921 aa)
RSU1Ras suppressor protein 1. (277 aa)
LOC110584449Arachidonate 15-lipoxygenase. (663 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
NID1Nidogen-1. (1241 aa)
THBS1Thrombospondin-1. (1170 aa)
GREM1Gremlin. (184 aa)
EPHA1Ephrin type-A receptor 1 isoform X1. (976 aa)
EGFLAMPikachurin. (1036 aa)
FBLN2Fibulin-2. (1228 aa)
HRGHistidine-rich glycoprotein. (532 aa)
PHLDB2Pleckstrin homology-like domain family B member 2. (1242 aa)
ECM2Extracellular matrix protein 2 isoform X1. (698 aa)
CCDC80Coiled-coil domain-containing protein 80. (956 aa)
KANK1KN motif and ankyrin repeat domain-containing protein 1 isoform X1. (1353 aa)
ANGPT2Angiopoietin-2. (541 aa)
LOC110584033Leucine-rich repeat-containing protein 45-like. (297 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (475 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (549 aa)
LOC110581667Protein unc-13 homolog D-like. (1079 aa)
LRRC45Leucine-rich repeat-containing protein 45. (384 aa)
LOC110583085Calmodulin-regulated spectrin-associated protein 3-like. (138 aa)
CORO2ACoronin; Belongs to the WD repeat coronin family. (520 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2567 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MELTFMelanotransferrin. (817 aa)
CYR61Protein CYR61. (382 aa)
APODApolipoprotein D. (188 aa)
ABI3BPTarget of Nesh-SH3. (1682 aa)
COL8A1Collagen alpha-1(VIII) chain. (743 aa)
LOC110581921Protein unc-13 homolog D. (1091 aa)
TSC1Hamartin. (1168 aa)
ABL1Tyrosine-protein kinase. (1137 aa)
TESK1Dual specificity testis-specific protein kinase 1. (628 aa)
CCL21C-C motif chemokine 21 isoform X1. (137 aa)
BST1ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2. (312 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
AGR2Anterior gradient protein 2 homolog. (175 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (715 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
HOXA7Homeobox protein Hox-A7. (234 aa)
LOC110577927TRIO and F-actin-binding protein-like. (637 aa)
S100A10Protein S100-A10 isoform X1; Belongs to the S-100 family. (115 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa)
FERMT1Fermitin family homolog 1 isoform X1. (678 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (807 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
ONECUT2One cut domain family member. (504 aa)
CRKLCrk-like protein. (303 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1573 aa)
PPM1FProtein phosphatase 1F. (496 aa)
LOC110578202LOW QUALITY PROTEIN: TRIO and F-actin-binding protein-like. (776 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
NEXMIFProtein KIAA2022 homolog. (1514 aa)
HSD17B12Very-long-chain 3-oxoacyl-CoA reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
EFEMP2EGF-containing fibulin-like extracellular matrix protein 2. (443 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CASS4Cas scaffolding protein family member 4. (786 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (22%) [HD]