STRINGSTRING
TP53 TP53 LEPR LEPR GFAP GFAP MECP2 MECP2 GBA GBA SHANK3 SHANK3 RB1 RB1 CSF1 CSF1 KRAS KRAS TREM2 TREM2 TREML1 TREML1 ORC3 ORC3 VEGFC VEGFC NTN1 NTN1 SOX4 SOX4 CSF1R CSF1R LGI4 LGI4 NF1 NF1 NF2 NF2 IL34 IL34
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LEPRLeptin receptor. (1166 aa)
GFAPGlial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. (432 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (487 aa)
GBAGlucosylceramidase. (547 aa)
SHANK3LOW QUALITY PROTEIN: SH3 and multiple ankyrin repeat domains protein 3. (1622 aa)
RB1Retinoblastoma-associated protein. (934 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
KRASGTPase KRas. (188 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
TREML1Trem-like transcript 1 protein. (312 aa)
ORC3Origin recognition complex subunit 3. (756 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
NTN1Netrin-1. (351 aa)
SOX4Transcription factor SOX. (474 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
LGI4Leucine-rich repeat LGI family member 4. (532 aa)
NF1Neurofibromin isoform X1. (2841 aa)
NF2Merlin isoform X1. (596 aa)
IL34Interleukin-34. (236 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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