52 items (Neomonachus schauinslandi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TSC1	Hamartin. (1168 aa)
	TMEM108	Transmembrane protein 108. (569 aa)
	XRCC1	DNA repair protein XRCC1. (630 aa)
	PROX1	Prospero homeobox protein 1. (737 aa)
	RELN	Reelin isoform X2. (3460 aa)
	BCAN	Brevican core protein. (912 aa)
	MFSD2A	Sodium-dependent lysophosphatidylcholine symporter 1 isoform X1. (529 aa)
	KIF14	Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
	ZIC3	Zinc finger protein ZIC 3 isoform X1. (466 aa)
	BBS1	Bardet-Biedl syndrome 1 protein. (593 aa)
	LRP8	Low-density lipoprotein receptor-related protein 8 isoform X1. (964 aa)
	DCX	Neuronal migration protein doublecortin. (396 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
	CRKL	Crk-like protein. (303 aa)
	BTG2	Protein BTG2. (162 aa)
	LOC110577734	Protein FAM205A-like. (530 aa)
	NEUROD6	Neurogenic differentiation factor. (337 aa)
	LOC110578784	LOW QUALITY PROTEIN: plexin-A3-like. (969 aa)
	MKKS	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (570 aa)
	SRF	Serum response factor isoform X1. (508 aa)
	HSD3B2	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; Belongs to the 3-beta-HSD family. (373 aa)
	GSK3B	Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
	LOC110582753	plexin-A3-like. (224 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	BBS4	Bardet-Biedl syndrome 4 protein. (521 aa)
	CDK5	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	FAM205A	Protein FAM205A. (738 aa)
	KIRREL3	LOW QUALITY PROTEIN: kin of IRRE-like protein 3. (765 aa)
	FEZF2	Fez family zinc finger protein 2. (465 aa)
	ALK	Tyrosine-protein kinase receptor. (1606 aa)
	LTK	LOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. (834 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	LHX5	LIM/homeobox protein Lhx5. (402 aa)
	ATAT1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (333 aa)
	EMX2	Homeobox protein EMX2 isoform X1. (253 aa)
	SMO	Smoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	NKX2-1	Homeobox protein Nkx-2.1. (403 aa)
	LOC110591028	Cytochrome b-c1 complex subunit 8. (82 aa)
	UBA6	Ubiquitin-like modifier-activating enzyme 6. (1052 aa)
	NKX2-2	Homeobox protein Nkx-2.2. (273 aa)
	DLX1	Homeobox protein DLX-1 isoform X1. (255 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (370 aa)
	GLI3	Transcriptional activator GLI3. (1589 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (308 aa)
	TSKU	Tsukushin. (442 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	NF2	Merlin isoform X1. (596 aa)
	DLX2	Homeobox protein DLX-2. (330 aa)
	PTPRS	Receptor-type tyrosine-protein phosphatase S. (1874 aa)
	OGDH	2-oxoglutarate dehydrogenase, mitochondrial. (1023 aa)
	CRK	Adapter molecule crk isoform X1. (304 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (721 aa)

Your Current Organism:

Neomonachus schauinslandi

NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALK	CRK	A0A2Y9HNX1	A0A2Y9IEK4	Tyrosine-protein kinase receptor.	Adapter molecule crk isoform X1.	0.432
ALK	CRKL	A0A2Y9HNX1	A0A2Y9GWH3	Tyrosine-protein kinase receptor.	Crk-like protein.	0.474
ALK	PTEN	A0A2Y9HNX1	A0A2Y9HQC2	Tyrosine-protein kinase receptor.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.557
BBS1	BBS2	A0A2Y9GNU6	A0A2Y9IGB6	Bardet-Biedl syndrome 1 protein.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS1	BBS4	A0A2Y9GNU6	A0A2Y9HCF0	Bardet-Biedl syndrome 1 protein.	Bardet-Biedl syndrome 4 protein.	0.999
BBS1	SMO	A0A2Y9GNU6	A0A2Y9HYQ2	Bardet-Biedl syndrome 1 protein.	Smoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.698
BBS2	BBS1	A0A2Y9IGB6	A0A2Y9GNU6	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 1 protein.	0.999
BBS2	BBS4	A0A2Y9IGB6	A0A2Y9HCF0	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4 protein.	0.999
BBS2	SMO	A0A2Y9IGB6	A0A2Y9HYQ2	Bardet-Biedl syndrome 2 protein homolog.	Smoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.630
BBS4	BBS1	A0A2Y9HCF0	A0A2Y9GNU6	Bardet-Biedl syndrome 4 protein.	Bardet-Biedl syndrome 1 protein.	0.999
BBS4	BBS2	A0A2Y9HCF0	A0A2Y9IGB6	Bardet-Biedl syndrome 4 protein.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS4	SMO	A0A2Y9HCF0	A0A2Y9HYQ2	Bardet-Biedl syndrome 4 protein.	Smoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.630
CDK5	CDK5R1	A0A2Y9HGG3	A0A2Y9I7S2	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 5 activator.	0.992
CDK5	CDK5R2	A0A2Y9HGG3	A0A2Y9I5C1	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 5 activator.	0.992
CDK5	GSK3B	A0A2Y9HGG3	A0A2Y9H9J4	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily.	Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily.	0.530
CDK5	LOC110578784	A0A2Y9HGG3	A0A2Y9H1X8	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily.	LOW QUALITY PROTEIN: plexin-A3-like.	0.486
CDK5	LOC110582753	A0A2Y9HGG3	A0A2Y9H9V5	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily.	plexin-A3-like.	0.486
CDK5R1	CDK5	A0A2Y9I7S2	A0A2Y9HGG3	Cyclin-dependent kinase 5 activator.	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily.	0.992
CDK5R1	GSK3B	A0A2Y9I7S2	A0A2Y9H9J4	Cyclin-dependent kinase 5 activator.	Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily.	0.479
CDK5R1	LOC110578784	A0A2Y9I7S2	A0A2Y9H1X8	Cyclin-dependent kinase 5 activator.	LOW QUALITY PROTEIN: plexin-A3-like.	0.407