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DDX3X DDX3X SFRP1 SFRP1 SPHK2 SPHK2 RBBP7 RBBP7 SEMA4B SEMA4B KIAA1024 KIAA1024 SLIT2 SLIT2 WNT3 WNT3 SH3BP4 SH3BP4 FBP1 FBP1 RYK RYK MSX1 MSX1 SEMA6A SEMA6A SPART SPART SEMA5A SEMA5A PHB PHB ACVRL1 ACVRL1 ACVR1B ACVR1B DIP2B DIP2B DNAJB2 DNAJB2 CDKN2D CDKN2D STK11 STK11 SEMA6B SEMA6B PPP1R9B PPP1R9B PTPRS PTPRS WNT11 WNT11 SMARCA4 SMARCA4 CRLF3 CRLF3 CIRBP CIRBP INHBA INHBA CUNH10orf90 CUNH10orf90 CDKL3 CDKL3 SERTAD3 SERTAD3 FRZB FRZB BMPR2 BMPR2 SEMA4C SEMA4C FSTL4 FSTL4 GDF9 GDF9 SIRT1 SIRT1 CGRRF1 CGRRF1 RTN4 RTN4 SERTAD1 SERTAD1 SEMA4F SEMA4F TGFB1 TGFB1 MYL10 MYL10 TSPYL2 TSPYL2 MYL2 MYL2 GDF2 GDF2 TGFB2 TGFB2 SEMA4G SEMA4G ST7 ST7 SERTAD2 SERTAD2 CCAR2 CCAR2 BMP10 BMP10 SFRP2 SFRP2 CDHR2 CDHR2 SLIT3 SLIT3 ULK1 ULK1 SEMA3G SEMA3G LOC110584655 LOC110584655 FLCN FLCN LOC110584353 LOC110584353 PML PML SEMA7A SEMA7A GNG4 GNG4 LOC110585737 LOC110585737 SMAD3 SMAD3 ENPP1 ENPP1 GJA1 GJA1 CDK5 CDK5 HRG HRG SEMA5B SEMA5B CPN2 CPN2 DCUN1D3 DCUN1D3 NTN1 NTN1 TP53 TP53 LOC110584346 LOC110584346 SMARCA2 SMARCA2 SEMA4D SEMA4D CDKN2AIP CDKN2AIP SEMA6D SEMA6D CDKN1B CDKN1B LOC110582753 LOC110582753 BCL6 BCL6 EAF2 EAF2 OSTN OSTN ST7L ST7L RACK1 RACK1 GSK3A GSK3A SEMA3A SEMA3A SEMA3D SEMA3D SEMA3C SEMA3C NAIF1 NAIF1 LOC110581163 LOC110581163 RTN4R RTN4R NOV NOV RERG RERG SOX17 SOX17 PSRC1 PSRC1 DCSTAMP DCSTAMP LOC110578784 LOC110578784 LOC110578214 LOC110578214 OSGIN2 OSGIN2 SEMA3E SEMA3E SEMA6C SEMA6C OSGIN1 OSGIN1 RB1 RB1 TP53TG5 TP53TG5 IFRD2 IFRD2 HNF4A HNF4A SEMA3B SEMA3B HYAL1 HYAL1 SEMA3F SEMA3F DCBLD2 DCBLD2 LOC110577978 LOC110577978 LOC110577862 LOC110577862 CDKN1C CDKN1C NME6 NME6 HYAL2 HYAL2 IP6K2 IP6K2 CCDC85B CCDC85B SMAD4 SMAD4 PI16 PI16 NDUFS3 NDUFS3 MUL1 MUL1 DRAXIN DRAXIN CDKN2C CDKN2C PTPRJ PTPRJ CDKN1A CDKN1A WT1 WT1 YJEFN3 YJEFN3 TNR TNR SESN2 SESN2 SEMA4A SEMA4A ADAM15 ADAM15 NDUFA13 NDUFA13 SERPINE2 SERPINE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
SPHK2Sphingosine kinase 2. (656 aa)
RBBP7Histone-binding protein RBBP7. (425 aa)
SEMA4Bsemaphorin-4B isoform X1; Belongs to the semaphorin family. (858 aa)
KIAA1024UPF0258 protein KIAA1024 homolog. (917 aa)
SLIT2Slit homolog 2 protein isoform X3. (1534 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
SH3BP4SH3 domain-binding protein 4. (962 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
RYKTyrosine-protein kinase RYK. (596 aa)
MSX1Homeobox protein MSX-1. (303 aa)
SEMA6Asemaphorin-6A; Belongs to the semaphorin family. (1030 aa)
SPARTSpartin. (670 aa)
SEMA5Asemaphorin-5A. (1073 aa)
PHBProhibitin. (272 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
DIP2BDisco-interacting protein 2 homolog B isoform X1. (1555 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X1. (399 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (596 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (636 aa)
PPP1R9BNeurabin-2. (285 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S. (1874 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SMARCA4Transcription activator BRG1 isoform X1. (1661 aa)
CRLF3Cytokine receptor-like factor 3. (438 aa)
CIRBPCold-inducible RNA-binding protein isoform X1. (185 aa)
INHBAInhibin beta A chain. (424 aa)
CUNH10orf90Centrosomal protein C10orf90 homolog isoform X1. (780 aa)
CDKL3LOW QUALITY PROTEIN: cyclin-dependent kinase-like 3. (590 aa)
SERTAD3SERTA domain-containing protein 3. (198 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (944 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
FSTL4Follistatin-related protein 4. (842 aa)
GDF9Growth/differentiation factor 9. (453 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (746 aa)
CGRRF1Cell growth regulator with RING finger domain protein 1. (332 aa)
RTN4Reticulon. (1196 aa)
SERTAD1SERTA domain-containing protein 1. (237 aa)
SEMA4FLOW QUALITY PROTEIN: semaphorin-4F; Belongs to the semaphorin family. (668 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MYL10Myosin regulatory light chain 10. (157 aa)
TSPYL2Testis-specific Y-encoded-like protein 2; Belongs to the nucleosome assembly protein (NAP) family. (753 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1. (166 aa)
GDF2Growth/differentiation factor 2. (429 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
SEMA4Gsemaphorin-4G; Belongs to the semaphorin family. (840 aa)
ST7Suppressor of tumorigenicity 7 protein isoform X1. (533 aa)
SERTAD2SERTA domain-containing protein 2. (319 aa)
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X1. (970 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
CDHR2Cadherin-related family member 2. (1308 aa)
SLIT3Slit homolog 3 protein. (1672 aa)
ULK1Serine/threonine-protein kinase ULK1. (1054 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (770 aa)
LOC110584655Four and a half LIM domains protein 1-like. (152 aa)
FLCNFolliculin isoform X1. (647 aa)
LOC110584353Neurabin-2-like. (242 aa)
PMLProtein PML isoform X1. (880 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (663 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC110585737Cytochrome P450 27C1; Belongs to the cytochrome P450 family. (416 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (924 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
CDK5Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
HRGHistidine-rich glycoprotein. (532 aa)
SEMA5Bsemaphorin-5B. (1089 aa)
CPN2Carboxypeptidase N subunit 2. (547 aa)
DCUN1D3DCN1-like protein. (304 aa)
NTN1Netrin-1. (351 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LOC110584346Uncharacterized protein LOC110584346. (349 aa)
SMARCA2Probable global transcription activator SNF2L2. (1510 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (1042 aa)
CDKN2AIPCDKN2A-interacting protein isoform X1. (582 aa)
SEMA6Dsemaphorin-6D; Belongs to the semaphorin family. (1073 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
LOC110582753plexin-A3-like. (224 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
EAF2ELL-associated factor 2. (264 aa)
OSTNOsteocrin. (132 aa)
ST7LSuppressor of tumorigenicity 7 protein-like. (556 aa)
RACK1Receptor of activated protein C kinase 1. (317 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
SEMA3Dsemaphorin-3D isoform X1; Belongs to the semaphorin family. (777 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (692 aa)
NAIF1Nuclear apoptosis-inducing factor 1. (327 aa)
LOC110581163ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (662 aa)
RTN4RReticulon-4 receptor. (667 aa)
NOVProtein NOV homolog. (353 aa)
RERGRas-related and estrogen-regulated growth inhibitor. (199 aa)
SOX17Transcription factor SOX-17. (406 aa)
PSRC1Proline/serine-rich coiled-coil protein 1 isoform X1. (326 aa)
DCSTAMPDendritic cell-specific transmembrane protein. (470 aa)
LOC110578784LOW QUALITY PROTEIN: plexin-A3-like. (969 aa)
LOC110578214Neurabin-2-like. (98 aa)
OSGIN2Oxidative stress-induced growth inhibitor 2. (549 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (715 aa)
SEMA6Csemaphorin-6C isoform X1; Belongs to the semaphorin family. (963 aa)
OSGIN1Oxidative stress-induced growth inhibitor 1. (499 aa)
RB1Retinoblastoma-associated protein. (934 aa)
TP53TG5TP53-target gene 5 protein. (246 aa)
IFRD2Interferon-related developmental regulator 2 isoform X1. (441 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (474 aa)
SEMA3Bsemaphorin-3B; Belongs to the semaphorin family. (748 aa)
HYAL1Hyaluronidase. (450 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (790 aa)
DCBLD2Discoidin, CUB and LCCL domain-containing protein 2. (776 aa)
LOC110577978Four and a half LIM domains protein 1. (119 aa)
LOC11057786225-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (263 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
HYAL2Hyaluronidase. (472 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
CCDC85BCoiled-coil domain-containing protein 85B. (202 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (458 aa)
NDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (262 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta. (1089 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
WT1Wilms tumor protein isoform X1. (302 aa)
YJEFN3yjeF N-terminal domain-containing protein 3. (250 aa)
TNRtenascin-R isoform X1. (1358 aa)
SESN2Sestrin-2. (481 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (708 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (893 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (144 aa)
SERPINE2Glia-derived nexin; Belongs to the serpin family. (397 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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