STRINGSTRING
EFNB3 EFNB3 CHRNB1 CHRNB1 DMRT3 DMRT3 HEXA HEXA BBS4 BBS4 PRKN PRKN GBX1 GBX1 DRD3 DRD3 KLHL4 KLHL4 DRD4 DRD4 CEND1 CEND1 NPY NPY TMOD1 TMOD1 SEPT5 SEPT5 PREX2 PREX2 EPS8 EPS8 CCND2 CCND2 OXR1 OXR1 CHD7 CHD7 CNTN2 CNTN2 SHANK3 SHANK3 PUM1 PUM1 OTOG OTOG SPTBN2 SPTBN2 SHANK2 SHANK2 BBS1 BBS1 OPRD1 OPRD1 SLC1A2 SLC1A2 PARK7 PARK7 BTBD9 BTBD9 CHRNA5 CHRNA5 GRIN2D GRIN2D SHANK1 SHANK1 NTF4 NTF4 MECP2 MECP2 NCSTN NCSTN ZMPSTE24 ZMPSTE24 DMBX1 DMBX1 FXN FXN EHMT2 EHMT2 ALK ALK LTK LTK SLITRK5 SLITRK5 PTEN PTEN ARCN1 ARCN1 CLCN3 CLCN3 GLRA1 GLRA1 ATP6V1B1 ATP6V1B1 LEP LEP PCDH17 PCDH17 KCNMA1 KCNMA1 BBS2 BBS2 TPGS1 TPGS1 SEZ6 SEZ6 HOXD9 HOXD9 GHSR GHSR PAFAH1B1 PAFAH1B1 NR4A2 NR4A2 GIP GIP RNF180 RNF180 PPP1R1B PPP1R1B CTNS CTNS HOXB8 HOXB8 AGRP AGRP EPHA4 EPHA4 HOXD10 HOXD10 CACNB4 CACNB4 LGI4 LGI4 INPP5F INPP5F SEZ6L2 SEZ6L2 KLHL5 KLHL5 HTRA2 HTRA2 GLRB GLRB CARTPT CARTPT ABAT ABAT KLHL1 KLHL1 CRHBP CRHBP HOMER1 HOMER1 CHRNA4 CHRNA4 AGTPBP1 AGTPBP1 LOC110570357 LOC110570357 SLC7A11 SLC7A11 TSHR TSHR UNC79 UNC79 SDK1 SDK1 CHRNB4 CHRNB4 CHRNA3 CHRNA3 MAFG MAFG HOMER2 HOMER2 CNP CNP KCNJ10 KCNJ10 CHRNB2 CHRNB2 NLGN3 NLGN3 TBCE TBCE SLITRK1 SLITRK1 OPRM1 OPRM1 EN1 EN1 ZFHX2 ZFHX2 CDK5 CDK5 HIPK2 HIPK2 CHL1 CHL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFNB3ephrin-B3; Belongs to the ephrin family. (340 aa)
CHRNB1Acetylcholine receptor subunit beta. (504 aa)
DMRT3Doublesex- and mab-3-related transcription factor 3. (458 aa)
HEXABeta-hexosaminidase. (543 aa)
BBS4Bardet-Biedl syndrome 4 protein. (521 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
GBX1Homeobox protein GBX-1. (360 aa)
DRD3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
KLHL4LOW QUALITY PROTEIN: kelch-like protein 4. (718 aa)
DRD4D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CEND1Cell cycle exit and neuronal differentiation protein 1. (148 aa)
NPYPro-neuropeptide Y. (97 aa)
TMOD1Tropomodulin-1. (359 aa)
SEPT5Septin-5 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (407 aa)
PREX2Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein. (1602 aa)
EPS8LOW QUALITY PROTEIN: epidermal growth factor receptor kinase substrate 8. (818 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
OXR1Oxidation resistance protein 1 isoform X4. (873 aa)
CHD7chromodomain-helicase-DNA-binding protein 7 isoform X1. (2997 aa)
CNTN2Contactin-2. (1040 aa)
SHANK3LOW QUALITY PROTEIN: SH3 and multiple ankyrin repeat domains protein 3. (1622 aa)
PUM1Pumilio homolog 1. (1200 aa)
OTOGOtogelin. (2925 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2397 aa)
SHANK2SH3 and multiple ankyrin repeat domains protein 2. (1800 aa)
BBS1Bardet-Biedl syndrome 1 protein. (593 aa)
OPRD1Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (372 aa)
SLC1A2Amino acid transporter. (565 aa)
PARK7LOW QUALITY PROTEIN: protein DJ-1-like. (189 aa)
BTBD9BTB/POZ domain-containing protein 9. (612 aa)
CHRNA5Neuronal acetylcholine receptor subunit alpha-5. (376 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D. (930 aa)
SHANK1SH3 and multiple ankyrin repeat domains protein 1. (2085 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (211 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (487 aa)
NCSTNNicastrin. (709 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
DMBX1Diencephalon/mesencephalon homeobox protein 1 isoform X1. (382 aa)
FXNFrataxin, mitochondrial. (211 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform X1. (1268 aa)
ALKTyrosine-protein kinase receptor. (1606 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. (834 aa)
SLITRK5SLIT and NTRK-like protein 5. (959 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ARCN1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (511 aa)
CLCN3Chloride channel protein. (866 aa)
GLRA1Glycine receptor subunit alpha-1 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PCDH17Protocadherin-17. (1162 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1 isoform X2. (1262 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
TPGS1Tubulin polyglutamylase complex subunit 1. (291 aa)
SEZ6Seizure protein 6 homolog isoform X1. (857 aa)
HOXD9Homeobox protein Hox-D9. (342 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
GIPGastric inhibitory polypeptide. (145 aa)
RNF180E3 ubiquitin-protein ligase RNF180. (592 aa)
PPP1R1BProtein phosphatase 1 regulatory subunit 1B. (169 aa)
CTNSCystinosin. (388 aa)
HOXB8Homeobox protein Hox-B8. (243 aa)
AGRPAgouti-related protein. (132 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
HOXD10Homeobox protein Hox-D10. (410 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
LGI4Leucine-rich repeat LGI family member 4. (532 aa)
INPP5FPhosphatidylinositide phosphatase SAC2 isoform X2. (1138 aa)
SEZ6L2Seizure 6-like protein 2 isoform X1. (923 aa)
KLHL5Kelch-like protein 5 isoform X1. (708 aa)
HTRA2Serine protease HTRA2, mitochondrial. (458 aa)
GLRBGlycine receptor subunit beta isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein. (116 aa)
ABAT4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
KLHL1Kelch-like protein 1 isoform X1. (749 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
HOMER1Homer protein homolog 1. (354 aa)
CHRNA4Neuronal acetylcholine receptor subunit alpha-4 isoform X1. (623 aa)
AGTPBP1Cytosolic carboxypeptidase 1. (1227 aa)
LOC110570357Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family. (421 aa)
SLC7A11Cystine/glutamate transporter. (503 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
UNC79Protein unc-79 homolog. (2684 aa)
SDK1Protein sidekick-1. (2112 aa)
CHRNB4Neuronal acetylcholine receptor subunit beta-4. (483 aa)
CHRNA3Neuronal acetylcholine receptor subunit alpha-3. (438 aa)
MAFGTranscription factor MafG. (162 aa)
HOMER2Homer protein homolog 2. (279 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (420 aa)
KCNJ10ATP-sensitive inward rectifier potassium channel 10. (379 aa)
CHRNB2Neuronal acetylcholine receptor subunit beta-2. (478 aa)
NLGN3Neuroligin-3. (646 aa)
TBCETubulin-specific chaperone E. (566 aa)
SLITRK1SLIT and NTRK-like protein 1. (696 aa)
OPRM1Mu-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (419 aa)
EN1Homeobox protein engrailed-like. (388 aa)
ZFHX2Zinc finger homeobox protein 2. (2568 aa)
CDK5Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
HIPK2Homeodomain-interacting protein kinase 2. (1195 aa)
CHL1Neural cell adhesion molecule L1-like protein. (1225 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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