STRINGSTRING
TREML1 TREML1 DUSP8 DUSP8 PTPN6 PTPN6 LOC110580602 LOC110580602 RAPGEF1 RAPGEF1 EZR EZR LOC110581877 LOC110581877 DEFB114 DEFB114 KLHL31 KLHL31 DUSP4 DUSP4 DUSP26 DUSP26 ADIPOQ ADIPOQ NCOR1 NCOR1 NLRP6 NLRP6 DLG1 DLG1 DUSP7 DUSP7 SPRED1 SPRED1 NDRG2 NDRG2 AGT AGT FLCN FLCN GPS2 GPS2 LOC110584772 LOC110584772 RANBP9 RANBP9 CAV3 CAV3 ITGB1BP1 ITGB1BP1 EMILIN1 EMILIN1 SPRY2 SPRY2 PTEN PTEN SORL1 SORL1 DUSP10 DUSP10 SH2B3 SH2B3 RGS14 RGS14 PEBP4 PEBP4 SFRP2 SFRP2 IRAK3 IRAK3 SLC9A3R1 SLC9A3R1 SYNJ2BP SYNJ2BP TMEM130 TMEM130 GPER1 GPER1 IGF1R IGF1R CAV1 CAV1 SPRED2 SPRED2 DUSP2 DUSP2 LOC110589411 LOC110589411 CBLC CBLC PRMT1 PRMT1 SPRY1 SPRY1 SFRP1 SFRP1 TNIP3 TNIP3 FOXO1 FOXO1 CD300A CD300A NUP62CL NUP62CL BMP7 BMP7 PRDM15 PRDM15 PSMD10 PSMD10 PTPRR PTPRR DUSP3 DUSP3 EFNA1 EFNA1 ASH1L ASH1L PTPRC PTPRC NUP62 NUP62 DUSP27 DUSP27 VRK3 VRK3 PTPN2 PTPN2 PIK3R2 PIK3R2 ERRFI1 ERRFI1 F2RL1 F2RL1 GBA GBA LILRA5 LILRA5 ATF3 ATF3 SPRY3 SPRY3 LEMD2 LEMD2 PTPRJ PTPRJ SMPD1 SMPD1 SMAD4 SMAD4 DLG2 DLG2 LAX1 LAX1 DAG1 DAG1 QARS QARS TBC1D10C TBC1D10C ANKRD26 ANKRD26 LOC110577921 LOC110577921 TIMP3 TIMP3 DUSP6 DUSP6 LOC110578183 LOC110578183 PTPN1 PTPN1 LOC110578762 LOC110578762 MYC MYC LYN LYN PSCA PSCA BMP2 BMP2 FBLN1 FBLN1 LOC110589565 LOC110589565 P2RX7 P2RX7 DUSP1 DUSP1 PBK PBK DUSP5 DUSP5 DACT1 DACT1 DUPD1 DUPD1 HMGCR HMGCR SPRY4 SPRY4 HDAC3 HDAC3 SPRED3 SPRED3 TNIP1 TNIP1 EPHA4 EPHA4 TAOK3 TAOK3 BMP4 BMP4 LOC110579845 LOC110579845 DUSP9 DUSP9 PTPN22 PTPN22 DUSP16 DUSP16 FOXM1 FOXM1 ZMYND11 ZMYND11 ABL1 ABL1 ITCH ITCH TLR4 TLR4 FKTN FKTN TREM2 TREM2 CYLD CYLD INPP5K INPP5K C1QL4 C1QL4 LIF LIF PEBP1 PEBP1 MARVELD3 MARVELD3 PIN1 PIN1 ABCA7 ABCA7 NF2 NF2 PAQR3 PAQR3 PAFAH1B1 PAFAH1B1 PHB PHB NF1 NF1 CUNH3orf33 CUNH3orf33 MECOM MECOM CDK5RAP3 CDK5RAP3 SEMA6A SEMA6A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TREML1Trem-like transcript 1 protein. (312 aa)
DUSP8Dual specificity protein phosphatase 8. (626 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
LOC110580602Ankyrin repeat domain-containing protein 26-like. (169 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1025 aa)
EZREzrin isoform X1. (586 aa)
LOC110581877Disabled homolog 2-interacting protein isoform X1. (1065 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (96 aa)
KLHL31Kelch-like protein 31. (634 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
DUSP26Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
ADIPOQAdiponectin. (244 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2458 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6 isoform X1. (893 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
DUSP7Dual specificity protein phosphatase 7. (270 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (442 aa)
NDRG2Protein NDRG2 isoform X1. (456 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
FLCNFolliculin isoform X1. (647 aa)
GPS2G protein pathway suppressor 2. (327 aa)
LOC110584772Toll-like receptor 9 isoform X1. (1328 aa)
RANBP9Ran-binding protein 9 isoform X2. (499 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ITGB1BP1Integrin beta-1-binding protein 1. (200 aa)
EMILIN1EMILIN-1. (1013 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SORL1Sortilin-related receptor. (2211 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
SH2B3SH2B adapter protein 3. (578 aa)
RGS14Regulator of G-protein signaling 14. (568 aa)
PEBP4Phosphatidylethanolamine-binding protein 4. (221 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
IRAK3Interleukin-1 receptor-associated kinase 3. (556 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF1. (280 aa)
SYNJ2BPSynaptojanin-2-binding protein. (145 aa)
TMEM130Transmembrane protein 130 isoform X1. (435 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SPRED2Sprouty-related, EVH1 domain-containing protein 2. (417 aa)
DUSP2Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (313 aa)
LOC110589411Dual specificity protein phosphatase 13; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (301 aa)
CBLCE3 ubiquitin-protein ligase CBL-C. (496 aa)
PRMT1Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
TNIP3TNFAIP3-interacting protein 3. (335 aa)
FOXO1Forkhead box protein O1. (663 aa)
CD300ACMRF35-like molecule 8. (311 aa)
NUP62CLNucleoporin-62 C-terminal-like protein. (265 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PRDM15PR domain zinc finger protein 15. (363 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
PTPRRReceptor-type tyrosine-protein phosphatase R isoform X2. (557 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
EFNA1ephrin-A1; Belongs to the ephrin family. (205 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L isoform X1. (2965 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1190 aa)
NUP62Nuclear pore glycoprotein p62. (532 aa)
DUSP27Inactive dual specificity phosphatase 27; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (1122 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X1. (493 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (460 aa)
F2RL1Proteinase-activated receptor 2. (409 aa)
GBAGlucosylceramidase. (547 aa)
LILRA5Leukocyte immunoglobulin-like receptor subfamily A member 5. (350 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3. (181 aa)
SPRY3Protein sprouty homolog 3. (288 aa)
LEMD2LEM domain-containing protein 2. (501 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta. (1089 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (680 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
LAX1Lymphocyte transmembrane adapter 1. (397 aa)
DAG1Dystroglycan. (891 aa)
QARSglutamine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (775 aa)
TBC1D10CCarabin. (446 aa)
ANKRD26Ankyrin repeat domain-containing protein 26. (441 aa)
LOC110577921Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like. (106 aa)
TIMP3Metalloproteinase inhibitor 3. (211 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
LOC110578183Coiled-coil domain-containing protein 144B-like. (184 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (453 aa)
LOC110578762PR domain zinc finger protein 15-like. (171 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
LYNTyrosine-protein kinase. (512 aa)
PSCAProstate stem cell antigen. (124 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa)
LOC110589565Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (188 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase. (322 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
DACT1Dapper homolog 1. (808 aa)
DUPD1Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (221 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (887 aa)
SPRY4Protein sprouty homolog 4. (299 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
SPRED3Sprouty-related, EVH1 domain-containing protein 3. (410 aa)
TNIP1TNFAIP3-interacting protein 1 isoform X1. (635 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
TAOK3Serine/threonine-protein kinase TAO3. (701 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (456 aa)
LOC110579845Ankyrin repeat domain-containing protein 26-like. (551 aa)
DUSP9Dual specificity protein phosphatase 9. (222 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22. (698 aa)
DUSP16Dual specificity protein phosphatase 16. (663 aa)
FOXM1Forkhead box protein M1. (748 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X1. (602 aa)
ABL1Tyrosine-protein kinase. (1137 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
FKTNFukutin. (461 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CYLDLOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (953 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (452 aa)
C1QL4Complement C1q-like protein 4. (238 aa)
LIFLeukemia inhibitory factor. (202 aa)
PEBP1Phosphatidylethanolamine-binding protein 1. (187 aa)
MARVELD3MARVEL domain-containing protein 3 isoform X2. (385 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (170 aa)
ABCA7LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 7. (2151 aa)
NF2Merlin isoform X1. (596 aa)
PAQR3Progestin and adipoQ receptor family member 3. (311 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
PHBProhibitin. (272 aa)
NF1Neurofibromin isoform X1. (2841 aa)
CUNH3orf33Protein C3orf33 homolog. (293 aa)
MECOMMDS1 and EVI1 complex locus protein EVI1. (1238 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3. (504 aa)
SEMA6Asemaphorin-6A; Belongs to the semaphorin family. (1030 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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