STRINGSTRING
CCDC125 CCDC125 SPRY4 SPRY4 LOC110591114 LOC110591114 PSD PSD RASA1 RASA1 ARAP3 ARAP3 SYNPO2L SYNPO2L RASGRP4 RASGRP4 RABGEF1 RABGEF1 AUTS2 AUTS2 PLCE1 PLCE1 GPR55 GPR55 LOC110589796 LOC110589796 RASAL1 RASAL1 LOC110587705 LOC110587705 NUP62 NUP62 PSD3 PSD3 RASIP1 RASIP1 PIK3CG PIK3CG CUL3 CUL3 SYDE1 SYDE1 NTRK1 NTRK1 DGKI DGKI LOC110582794 LOC110582794 NOTCH1 NOTCH1 RALGPS1 RALGPS1 RAPGEF1 RAPGEF1 ARFGEF3 ARFGEF3 F11R F11R MYOC MYOC ARHGEF2 ARHGEF2 ABCA1 ABCA1 LPAR1 LPAR1 ARHGEF10 ARHGEF10 KANK1 KANK1 EPS8L2 EPS8L2 ARHGAP44 ARHGAP44 ARHGEF3 ARHGEF3 GPR17 GPR17 GPR18 GPR18 TRIM67 TRIM67 DENND4A DENND4A RALGPS2 RALGPS2 MFN2 MFN2 KIF14 KIF14 RASAL3 RASAL3 SPRY3 SPRY3 F2RL3 F2RL3 SYNGAP1 SYNGAP1 MYO9B MYO9B MADD MADD ITGB1 ITGB1 DLC1 DLC1 FLCN FLCN FLOT1 FLOT1 RIPOR2 RIPOR2 IQSEC1 IQSEC1 STK19 STK19 LOC110585114 LOC110585114 PSD4 PSD4 RASGRP1 RASGRP1 KBTBD7 KBTBD7 SPRY2 SPRY2 CBL CBL FBXO8 FBXO8 FGF10 FGF10 NET1 NET1 STAMBP STAMBP GBF1 GBF1 RASGRF2 RASGRF2 SHOC2 SHOC2 F2RL1 F2RL1 F2R F2R F2RL2 F2RL2 RASGEF1A RASGEF1A ARFGEF2 ARFGEF2 RIPOR3 RIPOR3 ARHGEF25 ARHGEF25 NRP1 NRP1 KITLG KITLG CYTH4 CYTH4 BCR BCR LZTR1 LZTR1 MAPRE2 MAPRE2 ARHGAP17 ARHGAP17 ABRA ABRA LPAR4 LPAR4 ARFGEF1 ARFGEF1 DENND3 DENND3 GPR20 GPR20 LOC110579259 LOC110579259 SH3BP1 SH3BP1 GPR174 GPR174 SGSM3 SGSM3 CDC42SE1 CDC42SE1 LRRD1 LRRD1 CSF1 CSF1 SSX2IP SSX2IP NOTCH2 NOTCH2 KRAS KRAS EPS8 EPS8 SMIM10L1 SMIM10L1 FOXM1 FOXM1 RTN4R RTN4R LOC110579120 LOC110579120 ABCA2 ABCA2 LPAR6 LPAR6 LOC110581391 LOC110581391 ABL1 ABL1 MAPKAP1 MAPKAP1 SCAI SCAI CAVIN4 CAVIN4 EPS8L3 EPS8L3 MCF2L MCF2L RABL3 RABL3 ARHGDIB ARHGDIB IQSEC3 IQSEC3 SYDE2 SYDE2 HEG1 HEG1 BCL6 BCL6 STMN3 STMN3 ARFGAP1 ARFGAP1 LRRC7 LRRC7 STARD13 STARD13 NUP62CL NUP62CL FBP1 FBP1 GPR35 GPR35 ARHGAP42 ARHGAP42 LOC110570935 LOC110570935 ITPKB ITPKB GPR65 GPR65 RASA2 RASA2 PIK3CB PIK3CB EPO EPO STARD8 STARD8 AKAP13 AKAP13 OGT OGT ARHGDIA ARHGDIA OPHN1 OPHN1 MMD2 MMD2 CADM4 CADM4 CYTH2 CYTH2 ARHGAP35 ARHGAP35 SPRY1 SPRY1 CYTH3 CYTH3 ADGRG1 ADGRG1 LRRC59 LRRC59 P2RY8 P2RY8 ARHGEF18 ARHGEF18 GIT2 GIT2 KANK2 KANK2 TNFAIP1 TNFAIP1 GIT1 GIT1 NF1 NF1 ITGA3 ITGA3 ARHGAP24 ARHGAP24 ARF6 ARF6 ARHGEF28 ARHGEF28 CYTH1 CYTH1 DENND4B DENND4B RASGRF1 RASGRF1 EPS8L1 EPS8L1 DENND4C DENND4C PSD2 PSD2 CDC42SE2 CDC42SE2 KCTD10 KCTD10 LOC110591992 LOC110591992 COL3A1 COL3A1 KCTD13 KCTD13 LOC110589822 LOC110589822
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCDC125Coiled-coil domain-containing protein 125 isoform X1. (518 aa)
SPRY4Protein sprouty homolog 4. (299 aa)
LOC110591114IQ motif and SEC7 domain-containing protein 2. (1244 aa)
PSDPH and SEC7 domain-containing protein 1. (1028 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1039 aa)
ARAP3arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3. (1542 aa)
SYNPO2LSynaptopodin 2-like protein. (970 aa)
RASGRP4RAS guanyl-releasing protein 4. (673 aa)
RABGEF1Rab5 GDP/GTP exchange factor isoform X1. (492 aa)
AUTS2Autism susceptibility gene 2 protein. (1041 aa)
PLCE1Phosphoinositide phospholipase C. (2299 aa)
GPR55G-protein coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (320 aa)
LOC110589796Autism susceptibility gene 2 protein-like. (285 aa)
RASAL1rasGAP-activating-like protein 1. (805 aa)
LOC110587705LOW QUALITY PROTEIN: kelch repeat and BTB domain-containing protein 6-like. (689 aa)
NUP62Nuclear pore glycoprotein p62. (532 aa)
PSD3PH and SEC7 domain-containing protein 3. (1066 aa)
RASIP1Ras-interacting protein 1. (963 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa)
CUL3Cullin-3 isoform X1; Belongs to the cullin family. (768 aa)
SYDE1Rho GTPase-activating protein SYDE1. (735 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
DGKIDiacylglycerol kinase. (1058 aa)
LOC110582794Epidermal growth factor receptor kinase substrate 8-like protein 1. (183 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2567 aa)
RALGPS1Ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X1. (595 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1025 aa)
ARFGEF3Brefeldin A-inhibited guanine nucleotide-exchange protein 3. (2177 aa)
F11RJunctional adhesion molecule A. (298 aa)
MYOCMyocilin. (490 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (964 aa)
ABCA1ATP-binding cassette sub-family A member 1 isoform X1. (2261 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10 isoform X1. (1323 aa)
KANK1KN motif and ankyrin repeat domain-containing protein 1 isoform X1. (1353 aa)
EPS8L2Epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2. (717 aa)
ARHGAP44Rho GTPase-activating protein 44 isoform X1. (808 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (558 aa)
GPR17Uracil nucleotide/cysteinyl leukotriene receptor; Belongs to the G-protein coupled receptor 1 family. (339 aa)
GPR18N-arachidonyl glycine receptor; Belongs to the G-protein coupled receptor 1 family. (331 aa)
TRIM67Tripartite motif-containing protein 67 isoform X1. (781 aa)
DENND4AC-myc promoter-binding protein isoform X2. (1908 aa)
RALGPS2Ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2. (583 aa)
MFN2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
KIF14Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
RASAL3RAS protein activator like-3. (1012 aa)
SPRY3Protein sprouty homolog 3. (288 aa)
F2RL3Proteinase-activated receptor 4; Belongs to the G-protein coupled receptor 1 family. (390 aa)
SYNGAP1ras/Rap GTPase-activating protein SynGAP isoform X1. (1345 aa)
MYO9BUnconventional myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2154 aa)
MADDMAP kinase-activating death domain protein isoform X1. (1588 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
DLC1Rho GTPase-activating protein 7 isoform X1. (1527 aa)
FLCNFolliculin isoform X1. (647 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
RIPOR2Protein FAM65B isoform X1. (1043 aa)
IQSEC1LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 1. (1005 aa)
STK19Serine/threonine-protein kinase 19. (314 aa)
LOC110585114IQ motif and SEC7 domain-containing protein 1-like. (179 aa)
PSD4PH and SEC7 domain-containing protein 4 isoform X1. (1001 aa)
RASGRP1RAS guanyl-releasing protein 1. (956 aa)
KBTBD7Kelch repeat and BTB domain-containing protein 7. (679 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
FBXO8F-box only protein 8. (319 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
NET1Neuroepithelial cell-transforming gene 1 protein isoform X2. (596 aa)
STAMBPSTAM-binding protein. (424 aa)
GBF1Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1. (1861 aa)
RASGRF2Ras-specific guanine nucleotide-releasing factor 2. (1239 aa)
SHOC2Leucine-rich repeat protein SHOC-2. (582 aa)
F2RL1Proteinase-activated receptor 2. (409 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
F2RL2Proteinase-activated receptor 3. (377 aa)
RASGEF1Aras-GEF domain-containing family member 1A. (480 aa)
ARFGEF2Brefeldin A-inhibited guanine nucleotide-exchange protein 2. (1785 aa)
RIPOR3Protein FAM65C. (944 aa)
ARHGEF25Rho guanine nucleotide exchange factor 25 isoform X1. (619 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
CYTH4Cytohesin-4. (394 aa)
BCRBreakpoint cluster region protein isoform X1. (1282 aa)
LZTR1LOW QUALITY PROTEIN: leucine-zipper-like transcriptional regulator 1. (845 aa)
MAPRE2Microtubule-associated protein RP/EB family member 2 isoform X1. (326 aa)
ARHGAP17Rho GTPase-activating protein 17. (951 aa)
ABRAActin-binding Rho-activating protein. (380 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ARFGEF1Brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1. (1858 aa)
DENND3DENN domain-containing protein 3. (1273 aa)
GPR20G-protein coupled receptor 20; Belongs to the G-protein coupled receptor 1 family. (357 aa)
LOC110579259Putative P2Y purinoceptor 10. (347 aa)
SH3BP1SH3 domain-binding protein 1 isoform X1. (690 aa)
GPR174Probable G-protein coupled receptor 174. (330 aa)
SGSM3Small G protein signaling modulator 3 isoform X1. (757 aa)
CDC42SE1CDC42 small effector protein 1. (79 aa)
LRRD1Leucine-rich repeat and death domain-containing protein 1. (860 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
SSX2IPAfadin- and alpha-actinin-binding protein isoform X1. (618 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2471 aa)
KRASGTPase KRas. (188 aa)
EPS8LOW QUALITY PROTEIN: epidermal growth factor receptor kinase substrate 8. (818 aa)
SMIM10L1Small integral membrane protein 10-like protein 1. (68 aa)
FOXM1Forkhead box protein M1. (748 aa)
RTN4RReticulon-4 receptor. (667 aa)
LOC110579120Putative P2Y purinoceptor 10 isoform X1. (388 aa)
ABCA2ATP-binding cassette sub-family A member 2. (2468 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
LOC110581391ATP-binding cassette sub-family A member 1-like. (185 aa)
ABL1Tyrosine-protein kinase. (1137 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (522 aa)
SCAIProtein SCAI; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. (606 aa)
CAVIN4Muscle-related coiled-coil protein. (361 aa)
EPS8L3LOW QUALITY PROTEIN: epidermal growth factor receptor kinase substrate 8-like protein 3. (569 aa)
MCF2LGuanine nucleotide exchange factor DBS. (1203 aa)
RABL3Rab-like protein 3. (236 aa)
ARHGDIBRho GDP-dissociation inhibitor 2. (200 aa)
IQSEC3IQ motif and SEC7 domain-containing protein 3 isoform X1. (1207 aa)
SYDE2Rho GTPase-activating protein SYDE2. (1187 aa)
HEG1Protein HEG homolog 1. (1286 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
STMN3Stathmin; Belongs to the stathmin family. (180 aa)
ARFGAP1ADP-ribosylation factor GTPase-activating protein 1 isoform X1. (417 aa)
LRRC7Leucine-rich repeat-containing protein 7. (1542 aa)
STARD13stAR-related lipid transfer protein 13. (1123 aa)
NUP62CLNucleoporin-62 C-terminal-like protein. (265 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
GPR35LOW QUALITY PROTEIN: G-protein coupled receptor 35. (296 aa)
ARHGAP42Rho GTPase-activating protein 42. (874 aa)
LOC110570935G-protein coupled receptor 35-like; Belongs to the G-protein coupled receptor 1 family. (309 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (938 aa)
GPR65Psychosine receptor; Belongs to the G-protein coupled receptor 1 family. (341 aa)
RASA2Ras GTPase-activating protein 2 isoform X1. (850 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
STARD8LOW QUALITY PROTEIN: stAR-related lipid transfer protein 8. (1026 aa)
AKAP13A-kinase anchor protein 13. (2819 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. (1046 aa)
ARHGDIARho GDP-dissociation inhibitor 1. (204 aa)
OPHN1Oligophrenin-1. (749 aa)
MMD2Monocyte to macrophage differentiation factor 2. (263 aa)
CADM4Cell adhesion molecule 4. (416 aa)
CYTH2Cytohesin-2 isoform X1. (405 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
CYTH3Cytohesin-3 isoform X1. (351 aa)
ADGRG1Adhesion G-protein coupled receptor G1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (687 aa)
LRRC59Leucine-rich repeat-containing protein 59. (306 aa)
P2RY8P2Y purinoceptor 8; Belongs to the G-protein coupled receptor 1 family. (358 aa)
ARHGEF18LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 18. (1171 aa)
GIT2ARF GTPase-activating protein GIT2 isoform X6. (759 aa)
KANK2KN motif and ankyrin repeat domain-containing protein 2. (851 aa)
TNFAIP1BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2. (316 aa)
GIT1ARF GTPase-activating protein GIT1. (748 aa)
NF1Neurofibromin isoform X1. (2841 aa)
ITGA3LOW QUALITY PROTEIN: integrin alpha-3; Belongs to the integrin alpha chain family. (1050 aa)
ARHGAP24Rho GTPase-activating protein 24 isoform X1. (750 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1388 aa)
CYTH1Cytohesin-1 isoform X1. (399 aa)
DENND4BDENN domain-containing protein 4B. (1485 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1. (1257 aa)
EPS8L1Epidermal growth factor receptor kinase substrate 8-like protein 1. (431 aa)
DENND4CLOW QUALITY PROTEIN: DENN domain-containing protein 4C. (1950 aa)
PSD2PH and SEC7 domain-containing protein 2. (780 aa)
CDC42SE2CDC42 small effector protein 2. (84 aa)
KCTD10BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform X1. (316 aa)
LOC110591992LOW QUALITY PROTEIN: cytohesin-2-like. (322 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
KCTD13BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1. (330 aa)
LOC110589822Ras GTPase-activating protein 4. (801 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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