(70 nodes) Regulation of smooth muscle cell proliferation network (Neomonachus schauinslandi)

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Predicted Interactions

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Your Input:
	CNN1	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motifs 1. (952 aa)
	TGFB3	Transforming growth factor beta-3. (461 aa)
	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa)
	GPER1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	RBM10	RNA-binding protein 10. (853 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
	PTGIR	Prostacyclin receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	IL10	Interleukin-10. (178 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (374 aa)
	LOC110573152	Allograft inflammatory factor 1. (147 aa)
	HES5	Transcription factor HES-5. (165 aa)
	CTNNBIP1	Beta-catenin-interacting protein 1. (81 aa)
	MEF2D	Myocyte-specific enhancer factor 2D isoform X1. (515 aa)
	JUN	Transcription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
	MFN2	Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
	LDLRAP1	Low density lipoprotein receptor adapter protein 1. (309 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (161 aa)
	CDKN1C	Cyclin-dependent kinase inhibitor 1C. (263 aa)
	XRCC6	X-ray repair cross-complementing protein 6 isoform X1. (607 aa)
	PRKDC	DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (4135 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
	PDGFB	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	SULF1	LOW QUALITY PROTEIN: extracellular sulfatase Sulf-1. (1106 aa)
	FOXJ2	Forkhead box protein J2. (582 aa)
	TRIB1	Tribbles homolog 1 isoform X1. (375 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (629 aa)
	APOD	Apolipoprotein D. (188 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (198 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3 isoform X1. (795 aa)
	VIP	VIP peptides. (170 aa)
	ADIPOQ	Adiponectin. (244 aa)
	ALOX12	Arachidonate 12-lipoxygenase, 12S-type isoform X1. (663 aa)
	LOC110584672	Uncharacterized protein LOC110584672. (170 aa)
	FOXP1	Forkhead box protein P1 isoform X1. (577 aa)
	NDRG2	Protein NDRG2 isoform X1. (456 aa)
	THBS1	Thrombospondin-1. (1170 aa)
	MYOCD	Myocardin. (963 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	EDN1	Endothelin-1. (202 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	PRKG1	cGMP-dependent protein kinase. (726 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	MEF2C	Myocyte-specific enhancer factor 2C. (463 aa)
	CCDC142	Coiled-coil domain-containing protein 142. (766 aa)
	TCF7L2	Transcription factor 7-like 2. (446 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	PDCD4	Programmed cell death protein 4 isoform X1. (469 aa)
	HBEGF	Proheparin-binding EGF-like growth factor. (208 aa)
	XRCC5	X-ray repair cross-complementing protein 5 isoform X1. (733 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (944 aa)
	IGFBP5	Insulin-like growth factor-binding protein 5. (271 aa)
	CALCRL	Calcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (456 aa)
	IGFBP3	Insulin-like growth factor-binding protein 3. (164 aa)
	NDRG4	Protein NDRG4 isoform X1. (396 aa)
	NF1	Neurofibromin isoform X1. (2841 aa)
	PHB	Prohibitin. (272 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (653 aa)
	LOC110594100	LOW QUALITY PROTEIN: neutrophil elastase-like; Belongs to the peptidase S1 family. (284 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1613 aa)
	SERPINF2	Alpha-2-antiplasmin isoform X1; Belongs to the serpin family. (491 aa)
	CDH13	Cadherin-13. (713 aa)
	P2RY6	P2Y purinoceptor 6. (328 aa)

Your Current Organism:

Neomonachus schauinslandi

NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS1	HBEGF	A0A2Y9G7H6	A0A2Y9I0U7	A disintegrin and metalloproteinase with thrombospondin motifs 1.	Proheparin-binding EGF-like growth factor.	0.472
ADIPOQ	CDH13	A0A2Y9HEI6	A0A2Y9ICD5	Adiponectin.	Cadherin-13.	0.523
ADIPOQ	IFNG	A0A2Y9HEI6	A0A2Y9G5I4	Adiponectin.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.429
ADIPOQ	IL10	A0A2Y9HEI6	A0A2Y9GGF5	Adiponectin.	Interleukin-10.	0.619
ADIPOQ	PPARGC1A	A0A2Y9HEI6	A0A2Y9GBD4	Adiponectin.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.646
ADIPOQ	TLR4	A0A2Y9HEI6	A0A2Y9H646	Adiponectin.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.450
ADIPOQ	TNF	A0A2Y9HEI6	A0A2Y9HLR6	Adiponectin.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.591
BMP2	BMP4	A0A2Y9GZG1	A0A2Y9I682	Bone morphogenetic protein 2.	Bone morphogenetic protein 4 isoform X2.	0.926
BMP2	BMPR1A	A0A2Y9GZG1	A0A2Y9HVK5	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.999
BMP2	BMPR2	A0A2Y9GZG1	A0A2Y9I466	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.987
BMP2	CTNNB1	A0A2Y9GZG1	A0A2Y9G4Y4	Bone morphogenetic protein 2.	Catenin beta-1.	0.523
BMP2	FGF2	A0A2Y9GZG1	A0A2Y9GGR3	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP2	FGF9	A0A2Y9GZG1	A0A2Y9G4E6	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.521
BMP2	TNF	A0A2Y9GZG1	A0A2Y9HLR6	Bone morphogenetic protein 2.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.429
BMP4	BMP2	A0A2Y9I682	A0A2Y9GZG1	Bone morphogenetic protein 4 isoform X2.	Bone morphogenetic protein 2.	0.926
BMP4	BMPR1A	A0A2Y9I682	A0A2Y9HVK5	Bone morphogenetic protein 4 isoform X2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.995
BMP4	BMPR2	A0A2Y9I682	A0A2Y9I466	Bone morphogenetic protein 4 isoform X2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.989
BMP4	CTNNB1	A0A2Y9I682	A0A2Y9G4Y4	Bone morphogenetic protein 4 isoform X2.	Catenin beta-1.	0.621
BMP4	FGF2	A0A2Y9I682	A0A2Y9GGR3	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.753
BMP4	FGF9	A0A2Y9I682	A0A2Y9G4E6	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.584