(33 nodes) Embryonic cranial skeleton morphogenesis network (Neomonachus schauinslandi)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	TULP3	Tubby-like protein; Belongs to the TUB family. (462 aa)
	IFT140	Intraflagellar transport protein 140 homolog. (1459 aa)
	NIPBL	Nipped-B protein. (2803 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	MMP14	Matrix metalloproteinase-14. (582 aa)
	MTHFD1L	Monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1. (977 aa)
	IRX5	Iroquois-class homeodomain protein IRX-5. (483 aa)
	SLC39A3	Zinc transporter ZIP3. (314 aa)
	DLX2	Homeobox protein DLX-2. (330 aa)
	LHX1	LIM/homeobox protein Lhx1. (406 aa)
	WDR19	WD repeat-containing protein 19. (1342 aa)
	SIX4	Homeobox protein SIX4. (785 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (456 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	GLI3	Transcriptional activator GLI3. (1589 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	SIX2	Homeobox protein SIX2. (294 aa)
	NODAL	Nodal homolog. (348 aa)
	EIF4A3	Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family. (411 aa)
	LOC110584514	Mediator of RNA polymerase II transcription subunit 12. (758 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (522 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	ALX3	Homeobox protein aristaless-like 3. (343 aa)
	LOC110578682	Mediator of RNA polymerase II transcription subunit 12-like. (358 aa)
	CHST11	Carbohydrate sulfotransferase. (347 aa)
	HOXA2	Homeobox protein Hox-A2. (374 aa)
	SETD2	Histone-lysine N-methyltransferase SETD2. (2521 aa)
	MMP16	Matrix metalloproteinase-16. (607 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	SLC39A1	Zinc transporter ZIP1. (324 aa)
	MED12	Mediator of RNA polymerase II transcription subunit 12. (900 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (477 aa)
	TFAP2A	Transcription factor AP-2-alpha isoform X6. (576 aa)

Your Current Organism:

Neomonachus schauinslandi

NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	NODAL	A0A2Y9I682	A0A2Y9HVR5	Bone morphogenetic protein 4 isoform X2.	Nodal homolog.	0.435
BMP4	PDGFRA	A0A2Y9I682	A0A2Y9I564	Bone morphogenetic protein 4 isoform X2.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.526
BMP4	RUNX2	A0A2Y9I682	A0A2Y9HE63	Bone morphogenetic protein 4 isoform X2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.781
BMP4	SMAD3	A0A2Y9I682	A0A2Y9HII2	Bone morphogenetic protein 4 isoform X2.	Mothers against decapentaplegic homolog.	0.661
BMP4	TGFBR1	A0A2Y9I682	A0A2Y9HDE3	Bone morphogenetic protein 4 isoform X2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.787
GLI3	IFT140	A0A2Y9I5S5	A0A2Y9HWK7	Transcriptional activator GLI3.	Intraflagellar transport protein 140 homolog.	0.535
GLI3	PDGFRA	A0A2Y9I5S5	A0A2Y9I564	Transcriptional activator GLI3.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.525
IFT140	GLI3	A0A2Y9HWK7	A0A2Y9I5S5	Intraflagellar transport protein 140 homolog.	Transcriptional activator GLI3.	0.535
IFT140	TULP3	A0A2Y9HWK7	A0A2Y9H3X4	Intraflagellar transport protein 140 homolog.	Tubby-like protein; Belongs to the TUB family.	0.888
IFT140	WDR19	A0A2Y9HWK7	A0A2Y9I6T9	Intraflagellar transport protein 140 homolog.	WD repeat-containing protein 19.	0.998
LHX1	SIX1	A0A2Y9I8B4	A0A2Y9HZX9	LIM/homeobox protein Lhx1.	Homeobox protein SIX1.	0.537
LHX1	SIX2	A0A2Y9I8B4	A0A2Y9I3X1	LIM/homeobox protein Lhx1.	Homeobox protein SIX2.	0.537
LHX1	TFAP2A	A0A2Y9I8B4	A0A2Y9HLX1	LIM/homeobox protein Lhx1.	Transcription factor AP-2-alpha isoform X6.	0.506
LHX1	WNT9B	A0A2Y9I8B4	A0A2Y9G5B0	LIM/homeobox protein Lhx1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.618
LOC110578682	LOC110584514	A0A2Y9H1I3	A0A2Y9HF43	Mediator of RNA polymerase II transcription subunit 12-like.	Mediator of RNA polymerase II transcription subunit 12.	0.948
LOC110578682	MED12	A0A2Y9H1I3	A0A2Y9GBD6	Mediator of RNA polymerase II transcription subunit 12-like.	Mediator of RNA polymerase II transcription subunit 12.	0.938
LOC110584514	LOC110578682	A0A2Y9HF43	A0A2Y9H1I3	Mediator of RNA polymerase II transcription subunit 12.	Mediator of RNA polymerase II transcription subunit 12-like.	0.948
LOC110584514	MED12	A0A2Y9HF43	A0A2Y9GBD6	Mediator of RNA polymerase II transcription subunit 12.	Mediator of RNA polymerase II transcription subunit 12.	0.936
MED12	LOC110578682	A0A2Y9GBD6	A0A2Y9H1I3	Mediator of RNA polymerase II transcription subunit 12.	Mediator of RNA polymerase II transcription subunit 12-like.	0.938
MED12	LOC110584514	A0A2Y9GBD6	A0A2Y9HF43	Mediator of RNA polymerase II transcription subunit 12.	Mediator of RNA polymerase II transcription subunit 12.	0.936