STRINGSTRING
PIK3CD PIK3CD VEGFB VEGFB APLNR APLNR JUN JUN STAT3 STAT3 CCR3 CCR3 EMC10 EMC10 PRKD2 PRKD2 LOC110573272 LOC110573272 AKT3 AKT3 KDM5B KDM5B FGF2 FGF2 PROX1 PROX1 VASH2 VASH2 FPR2 FPR2 IL10 IL10 ZNF304 ZNF304 ZNF580 ZNF580 IQGAP3 IQGAP3 GRN GRN ZNF703 ZNF703 SFRP1 SFRP1 C5AR2 C5AR2 PRKD1 PRKD1 MTA3 MTA3 RREB1 RREB1 BMP6 BMP6 TNF TNF SCG2 SCG2 TGM1 TGM1 PTN PTN TP63 TP63 PKHD1 PKHD1 RUNX2 RUNX2 VEGFC VEGFC TGFBR1 TGFBR1 VEGFA VEGFA FGF7 FGF7 VIP VIP TNFAIP3 TNFAIP3 NOTCH1 NOTCH1 NRARP NRARP PROK1 PROK1 CLDN1 CLDN1 FLT4 FLT4 HRAS HRAS BMP5 BMP5 NRAS NRAS SRSF6 SRSF6 B4GALT1 B4GALT1 EGFL7 EGFL7 LOC110579526 LOC110579526 ST8SIA1 ST8SIA1 ECM1 ECM1 HTR2B HTR2B AKT1 AKT1 TCF7L2 TCF7L2 BMPR1A BMPR1A NODAL NODAL GDF2 GDF2 EGR3 EGR3 CCL24 CCL24 NKX2-6 NKX2-6 SMO SMO RTN4 RTN4 APELA APELA KDR KDR WNT2 WNT2 SIRT1 SIRT1 FGF1 FGF1 AGGF1 AGGF1 ODAM ODAM CCL26 CCL26 HPN HPN BMPR2 BMPR2 AKT2 AKT2 XBP1 XBP1 BMP4 BMP4 HMX2 HMX2 EGFR EGFR HSF4 HSF4 MED1 MED1 NF1 NF1 ITGA4 ITGA4 NOD2 NOD2 ACVRL1 ACVRL1 EPGN EPGN MYDGF MYDGF SIRT6 SIRT6 OSR1 OSR1 FZD7 FZD7 LRG1 LRG1 ESRP2 ESRP2 CDH13 CDH13 NOTCH2 NOTCH2 CDH3 CDH3 NOG NOG STXBP4 STXBP4 PDPK1 PDPK1 HLX HLX FGF10 FGF10 YAP1 YAP1 TGFA TGFA THBS4 THBS4 WDR48 WDR48 FGF9 FGF9 ITGB3 ITGB3 SOX9 SOX9 PDX1 PDX1 PRKCA PRKCA FGFBP1 FGFBP1 PGF PGF HMGB1 HMGB1 PDCL3 PDCL3 C5AR1 C5AR1 F3 F3 OSR2 OSR2 PDGFB PDGFB DLX6 DLX6 DLX5 DLX5 HMOX1 HMOX1 BMP2 BMP2 SP1 SP1 MYC MYC EYA1 EYA1 JCAD JCAD AGAP2 AGAP2 PDCD6 PDCD6 BAD BAD MST1 MST1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
EMC10ER membrane protein complex subunit 10 isoform X1. (262 aa)
PRKD2Serine/threonine-protein kinase D2. (725 aa)
LOC110573272Signal transducer and activator of transcription 5A. (478 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
KDM5BLysine-specific demethylase 5B isoform X1. (1544 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (374 aa)
PROX1Prospero homeobox protein 1. (737 aa)
VASH2Vasohibin-2 isoform X1. (355 aa)
FPR2N-formyl peptide receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
IL10Interleukin-10. (178 aa)
ZNF304Zinc finger protein 304. (660 aa)
ZNF580Zinc finger protein 580. (172 aa)
IQGAP3Ras GTPase-activating-like protein IQGAP3. (1629 aa)
GRNGranulins. (587 aa)
ZNF703Zinc finger protein 703. (591 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
C5AR2C5a anaphylatoxin chemotactic receptor 2. (337 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
MTA3Metastasis-associated protein MTA3. (532 aa)
RREB1Ras-responsive element-binding protein 1. (1768 aa)
BMP6Bone morphogenetic protein 6. (490 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SCG2Secretogranin-2. (618 aa)
TGM1Protein-glutamine gamma-glutamyltransferase K. (812 aa)
PTNPleiotrophin. (168 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (587 aa)
PKHD1Fibrocystin. (4075 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (522 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (549 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
VIPVIP peptides. (170 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (795 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2567 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
PROK1Prokineticin-1. (105 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa)
HRASGTPase HRas isoform X1. (189 aa)
BMP5Bone morphogenetic protein 5 isoform X1. (472 aa)
NRASGTPase NRas. (189 aa)
SRSF6Serine/arginine-rich splicing factor 6. (344 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (400 aa)
EGFL7Epidermal growth factor-like protein 7 isoform X1. (306 aa)
LOC110579526Signal transducer and activator of transcription 5A-like. (153 aa)
ST8SIA1alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Belongs to the glycosyltransferase 29 family. (356 aa)
ECM1LOW QUALITY PROTEIN: extracellular matrix protein 1. (550 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TCF7L2Transcription factor 7-like 2. (446 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NODALNodal homolog. (348 aa)
GDF2Growth/differentiation factor 2. (429 aa)
EGR3Early growth response protein 3. (387 aa)
CCL24C-C motif chemokine 24. (109 aa)
NKX2-6Homeobox protein Nkx-2.6. (302 aa)
SMOSmoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
RTN4Reticulon. (1196 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (746 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
AGGF1Angiogenic factor with G patch and FHA domains 1. (716 aa)
ODAMLOW QUALITY PROTEIN: odontogenic ameloblast-associated protein. (267 aa)
CCL26C-C motif chemokine. (94 aa)
HPNSerine protease hepsin isoform X1; Belongs to the peptidase S1 family. (432 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (944 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (390 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (456 aa)
HMX2Homeobox protein HMX2. (273 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
HSF4Heat shock factor protein 4 isoform X1. (493 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
NF1Neurofibromin isoform X1. (2841 aa)
ITGA4LOW QUALITY PROTEIN: integrin alpha-4; Belongs to the integrin alpha chain family. (1039 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
EPGNEpigen isoform X1. (153 aa)
MYDGFMyeloid-derived growth factor. (272 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (354 aa)
ESRP2Epithelial splicing regulatory protein 2 isoform X1. (717 aa)
CDH13Cadherin-13. (713 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2471 aa)
CDH3Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (828 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
STXBP4Syntaxin-binding protein 4. (558 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (571 aa)
HLXH2.0-like homeobox protein. (479 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
YAP1Transcriptional coactivator YAP1. (437 aa)
TGFAProtransforming growth factor alpha. (160 aa)
THBS4Thrombospondin-4 isoform X1. (961 aa)
WDR48WD repeat-containing protein 48 isoform X2. (677 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
SOX9Transcription factor SOX-9. (509 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (255 aa)
PGFPlacenta growth factor isoform X2; Belongs to the PDGF/VEGF growth factor family. (170 aa)
HMGB1High mobility group protein B1. (215 aa)
PDCL3Phosducin-like protein 3. (240 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (288 aa)
OSR2Protein odd-skipped-related 2 isoform X2. (312 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
DLX6Homeobox protein DLX-6. (290 aa)
DLX5Homeobox protein DLX-5. (289 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SP1Transcription factor Sp1. (786 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
JCADJunctional protein associated with coronary artery disease. (1371 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (1197 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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