STRINGSTRING
NOG NOG NOTCH1 NOTCH1 CITED2 CITED2 TGFBR1 TGFBR1 FGF20 FGF20 JARID2 JARID2 PTEN PTEN TBX5 TBX5 YAP1 YAP1 BMP10 BMP10 MEF2C MEF2C TBX20 TBX20 BMPR1A BMPR1A WNT2 WNT2 ERBB4 ERBB4 SAV1 SAV1 ZFPM2 ZFPM2 TBX2 TBX2 GATA6 GATA6 GLI1 GLI1 PIM1 PIM1 TP73 TP73 FGF2 FGF2 FGF9 FGF9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2567 aa)
CITED2LOW QUALITY PROTEIN: cbp/p300-interacting transactivator 2. (272 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
JARID2Protein Jumonji isoform X1. (1250 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TBX5T-box transcription factor TBX5. (518 aa)
YAP1Transcriptional coactivator YAP1. (437 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
MEF2CMyocyte-specific enhancer factor 2C. (463 aa)
TBX20T-box transcription factor TBX20. (447 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ERBB4Receptor protein-tyrosine kinase. (1270 aa)
SAV1Protein salvador homolog 1. (384 aa)
ZFPM2Zinc finger protein ZFPM2. (1148 aa)
TBX2T-box transcription factor TBX2. (713 aa)
GATA6Transcription factor GATA-6. (593 aa)
GLI1LOW QUALITY PROTEIN: zinc finger protein GLI1. (1105 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (320 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (617 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (374 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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