STRINGSTRING
ITPRIP ITPRIP CDIP1 CDIP1 LOC110589396 LOC110589396 TGFB2 TGFB2 P2RX7 P2RX7 NUPR1 NUPR1 NOL3 NOL3 HIP1 HIP1 ITPRIPL2 ITPRIPL2 LOC110589905 LOC110589905 LOC110589957 LOC110589957 TGFB1 TGFB1 P2RX4 P2RX4 TIMM50 TIMM50 MSH2 MSH2 ERO1A ERO1A MSH6 MSH6 HTRA2 HTRA2 SIRT1 SIRT1 VDAC2 VDAC2 SGPL1 SGPL1 SFN SFN CASP9 CASP9 FADD FADD RAD9A RAD9A LGALS12 LGALS12 TMEM109 TMEM109 CDKN1A CDKN1A PPARD PPARD DAXX DAXX BAK1 BAK1 FASLG FASLG YJEFN3 YJEFN3 STK26 STK26 PHLDA3 PHLDA3 TFPT TFPT UBE4B UBE4B IFI6 IFI6 E2F2 E2F2 TNFRSF1B TNFRSF1B TP73 TP73 POLB POLB NDUFA13 NDUFA13 IVNS1ABP IVNS1ABP LOC110574141 LOC110574141 MAEL MAEL IL2 IL2 G0S2 G0S2 PTPRC PTPRC DEDD DEDD DDX3X DDX3X BCL2A1 BCL2A1 SFRP1 SFRP1 BAX BAX BBC3 BBC3 BCL3 BCL3 BDKRB2 BDKRB2 TP53BP2 TP53BP2 AEN AEN STK25 STK25 TM2D1 TM2D1 PAWR PAWR PPP1R13B PPP1R13B BOK BOK SIVA1 SIVA1 GSKIP GSKIP SNW1 SNW1 LOC110571533 LOC110571533 ERN1 ERN1 PDX1 PDX1 FGFR3 FGFR3 DDX5 DDX5 DYRK2 DYRK2 IFNG IFNG BRCA2 BRCA2 DIDO1 DIDO1 DAPK1 DAPK1 KIAA0141 KIAA0141 ATP2A1 ATP2A1 PIK3R1 PIK3R1 ZNF622 ZNF622 DAP DAP ZNF385B ZNF385B SKIL SKIL PDK1 PDK1 CASP10 CASP10 CD28 CD28 CFLAR CFLAR DAPL1 DAPL1 CHEK2 CHEK2 BNIP3 BNIP3 INHBA INHBA PCGF2 PCGF2 FAIM2 FAIM2 TMEM117 TMEM117 ATP2A3 ATP2A3 RHOT1 RHOT1 PDK2 PDK2 SENP1 SENP1 COL2A1 COL2A1 ATF2 ATF2 ATAD5 ATAD5 ITGAV ITGAV WWOX WWOX NANOS3 NANOS3 STK11 STK11 PDCD10 PDCD10 CASP8 CASP8 ACVR1B ACVR1B NF1 NF1 HIC1 HIC1 RETREG1 RETREG1 TRADD TRADD CTTN CTTN AIFM1 AIFM1 RRP8 RRP8 CEBPB CEBPB PTGIS PTGIS EPHA2 EPHA2 RNF186 RNF186 BCL2 BCL2 CASP6 CASP6 LOC110576070 LOC110576070 LOC110577369 LOC110577369 IKBKE IKBKE CD5 CD5 KRT18 KRT18 NOX1 NOX1 ERN2 ERN2 QRICH1 QRICH1 BAD BAD SHISA5 SHISA5 DDIT3 DDIT3 USP47 USP47 KITLG KITLG ADORA2A ADORA2A PPM1F PPM1F MCL1 MCL1 NBN NBN KRT8 KRT8 EYA1 EYA1 PMAIP1 PMAIP1 MYC MYC PRKDC PRKDC STK3 STK3 ERBB3 ERBB3 EP300 EP300 CRADD CRADD EYA2 EYA2 STK4 STK4 ATF4 ATF4 TRIB3 TRIB3 RNF41 RNF41 TMBIM7P TMBIM7P MAPK9 MAPK9 RB1CC1 RB1CC1 NGF NGF IL7 IL7 PIDD1 PIDD1 MLLT11 MLLT11 DDX47 DDX47 TNFRSF1A TNFRSF1A DNM1L DNM1L LOC110581163 LOC110581163 ABL1 ABL1 GGCT GGCT BCL2L1 BCL2L1 E2F1 E2F1 TOPORS TOPORS LOC110582118 LOC110582118 GSK3A GSK3A DEDD2 DEDD2 HIPK1 HIPK1 CD27 CD27 GSK3B GSK3B SORT1 SORT1 MAP3K5 MAP3K5 CASP8AP2 CASP8AP2 BCL2L10 BCL2L10 FOXO3 FOXO3 LOC110581877 LOC110581877 MELK MELK CASP3 CASP3 LOC110584341 LOC110584341 TP53 TP53 TP63 TP63 ITPR1 ITPR1 HIPK2 HIPK2 RAF1 RAF1 CASP2 CASP2 ELL3 ELL3 NFATC4 NFATC4 PARP2 PARP2 LOC110585402 LOC110585402 CHAC1 CHAC1 SMAD3 SMAD3 UACA UACA FAS FAS PML PML TLR3 TLR3 CD3E CD3E LOC110586195 LOC110586195 LOC110586231 LOC110586231 IL18 IL18 MYBBP1A MYBBP1A LOC110584488 LOC110584488 FLCN FLCN RIPK1 RIPK1 BAG6 BAG6 TNF TNF INCA1 INCA1 FHIT FHIT PDIA3 PDIA3 BCL2L11 BCL2L11 LOC110585403 LOC110585403 INHBB INHBB PDPK1 PDPK1 RHOT2 RHOT2 ATM ATM DIABLO DIABLO FGF10 FGF10 BMI1 BMI1 YAP1 YAP1 BNIP3L BNIP3L ANXA6 ANXA6 CLU CLU LOC110587203 LOC110587203 CAV1 CAV1 BAG3 BAG3 JMY JMY DDIT4 DDIT4 ERCC6 ERCC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPRIPInositol 1,4,5-trisphosphate receptor-interacting protein isoform X2. (552 aa)
CDIP1Cell death-inducing p53-target protein 1. (208 aa)
LOC110589396LOW QUALITY PROTEIN: SNW domain-containing protein 1-like. (400 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
NUPR1Nuclear protein 1 isoform X1. (83 aa)
NOL3Nucleolar protein 3. (214 aa)
HIP1Huntingtin-interacting protein 1. (913 aa)
ITPRIPL2Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa)
LOC110589905Apoptosis-associated speck-like protein containing a CARD. (194 aa)
LOC110589957Mitochondrial fission 1 protein isoform X1. (191 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (435 aa)
TIMM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (229 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
ERO1AERO1-like protein alpha isoform X1. (468 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1362 aa)
HTRA2Serine protease HTRA2, mitochondrial. (458 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (746 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (294 aa)
SGPL1Sphingosine-1-phosphate lyase 1 isoform X1. (568 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (447 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (418 aa)
LGALS12Galectin. (305 aa)
TMEM109Transmembrane protein 109. (243 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
DAXXDeath domain-associated protein 6. (750 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
FASLGTumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (281 aa)
YJEFN3yjeF N-terminal domain-containing protein 3. (250 aa)
STK26Serine/threonine-protein kinase 26 isoform X1. (416 aa)
PHLDA3Pleckstrin homology-like domain family A member 3. (125 aa)
TFPTTCF3 fusion partner isoform X1. (280 aa)
UBE4BUbiquitin conjugation factor E4 B. (1311 aa)
IFI6Interferon alpha-inducible protein 6. (136 aa)
E2F2Transcription factor E2F2. (449 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B isoform X1. (464 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (617 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (144 aa)
IVNS1ABPInfluenza virus NS1A-binding protein isoform X1. (643 aa)
LOC110574141Apoptogenic protein 1, mitochondrial-like. (192 aa)
MAELProtein maelstrom homolog isoform X1. (426 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
G0S2G0/G1 switch protein 2. (103 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1190 aa)
DEDDDeath effector domain-containing protein. (318 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
BCL2A1Bcl-2-related protein A1. (210 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
BBC3Bcl-2-binding component 3. (193 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
TP53BP2Apoptosis-stimulating of p53 protein 2 isoform X1. (1154 aa)
AENApoptosis-enhancing nuclease. (325 aa)
STK25Serine/threonine-protein kinase 25. (426 aa)
TM2D1TM2 domain-containing protein 1 isoform X1. (205 aa)
PAWRPRKC apoptosis WT1 regulator protein. (343 aa)
PPP1R13BApoptosis-stimulating of p53 protein 1 isoform X1. (1030 aa)
BOKBcl-2-related ovarian killer protein isoform X1. (220 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
GSKIPGSK3-beta interaction protein. (137 aa)
SNW1SNW domain-containing protein 1 isoform X1. (571 aa)
LOC110571533Interferon alpha-inducible protein 27-like protein 2. (177 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1. (601 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3446 aa)
DIDO1Death-inducer obliterator 1. (2195 aa)
DAPK1Death-associated protein kinase 1. (1370 aa)
KIAA0141Death ligand signal enhancer. (522 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1088 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
ZNF622Zinc finger protein 622 isoform X1. (476 aa)
DAPDeath-associated protein 1. (102 aa)
ZNF385BZinc finger protein 385B isoform X1. (538 aa)
SKILSki-like protein isoform X1. (684 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (481 aa)
CD28T-cell-specific surface glycoprotein CD28. (221 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (482 aa)
DAPL1Death-associated protein-like 1. (107 aa)
CHEK2Serine/threonine-protein kinase Chk2. (544 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
INHBAInhibin beta A chain. (424 aa)
PCGF2Polycomb group RING finger protein 2 isoform X1. (419 aa)
FAIM2Protein lifeguard 2 isoform X1; Belongs to the BI1 family. (315 aa)
TMEM117Transmembrane protein 117. (370 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1038 aa)
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (704 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
SENP1Sentrin-specific protease 1. (645 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1862 aa)
ITGAVIntegrin alpha-V isoform X1; Belongs to the integrin alpha chain family. (1047 aa)
WWOXWW domain-containing oxidoreductase. (414 aa)
NANOS3Nanos homolog 3; Belongs to the nanos family. (173 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (596 aa)
PDCD10Programmed cell death protein 10. (212 aa)
CASP8LOW QUALITY PROTEIN: caspase-8; Belongs to the peptidase C14A family. (486 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
NF1Neurofibromin isoform X1. (2841 aa)
HIC1LOW QUALITY PROTEIN: hypermethylated in cancer 1 protein. (716 aa)
RETREG1Reticulophagy receptor FAM134B isoform X1. (495 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1. (312 aa)
CTTNSrc substrate cortactin isoform X1. (543 aa)
AIFM1Apoptosis-inducing factor 1, mitochondrial. (613 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (457 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
PTGISProstacyclin synthase; Belongs to the cytochrome P450 family. (499 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
RNF186RING finger protein 186. (233 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
CASP6Caspase-6 isoform X1; Belongs to the peptidase C14A family. (293 aa)
LOC110576070Tumor necrosis factor receptor superfamily member 1A-like isoform X1. (459 aa)
LOC110577369LOW QUALITY PROTEIN: gamma-glutamylcyclotransferase-like. (188 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (774 aa)
CD5T-cell surface glycoprotein CD5. (515 aa)
KRT18Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (315 aa)
NOX1NADPH oxidase 1. (572 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (926 aa)
QRICH1Glutamine-rich protein 1 isoform X1. (779 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
SHISA5Protein shisa-5 isoform X1. (237 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1355 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
PPM1FProtein phosphatase 1F. (496 aa)
MCL1LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1. (347 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (729 aa)
KRT8Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (489 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
PRKDCDNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (4135 aa)
STK3Serine/threonine-protein kinase 3. (491 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
EP300Histone acetyltransferase p300. (2420 aa)
CRADDDeath domain-containing protein CRADD. (199 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
TRIB3Tribbles homolog 3. (358 aa)
RNF41E3 ubiquitin-protein ligase NRDP1. (317 aa)
TMBIM7PProtein lifeguard 2; Belongs to the BI1 family. (301 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (159 aa)
PIDD1P53-induced death domain-containing protein 1. (915 aa)
MLLT11Protein AF1q. (89 aa)
DDX47Probable ATP-dependent RNA helicase DDX47; Belongs to the DEAD box helicase family. (455 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (451 aa)
DNM1LDynamin-1-like protein isoform X4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
LOC110581163ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (662 aa)
ABL1Tyrosine-protein kinase. (1137 aa)
GGCTGamma-glutamylcyclotransferase. (188 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
TOPORSE3 ubiquitin-protein ligase Topors. (1043 aa)
LOC110582118BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1. (223 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
DEDD2DNA-binding death effector domain-containing protein 2 isoform X1. (327 aa)
HIPK1LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 1. (1210 aa)
CD27CD27 antigen. (261 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
SORT1Sortilin. (835 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
CASP8AP2CASP8-associated protein 2. (1970 aa)
BCL2L10Bcl-2-like protein 10. (226 aa)
FOXO3Forkhead box protein O3. (672 aa)
LOC110581877Disabled homolog 2-interacting protein isoform X1. (1065 aa)
MELKNon-specific serine/threonine protein kinase. (651 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
LOC110584341Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (430 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (587 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
HIPK2Homeodomain-interacting protein kinase 2. (1195 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
CASP2Caspase-2; Belongs to the peptidase C14A family. (452 aa)
ELL3RNA polymerase II elongation factor ELL3. (397 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4. (902 aa)
PARP2Poly [ADP-ribose] polymerase. (566 aa)
LOC110585402Polyadenylate-binding protein 2. (306 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (397 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1403 aa)
FASTumor necrosis factor receptor superfamily member 6. (314 aa)
PMLProtein PML isoform X1. (880 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
LOC110586195Caspase-13-like isoform X1; Belongs to the peptidase C14A family. (485 aa)
LOC110586231Caspase-12-like; Belongs to the peptidase C14A family. (389 aa)
IL18Interleukin-18 isoform X1. (344 aa)
MYBBP1AMyb-binding protein 1A. (1127 aa)
LOC110584488Tumor necrosis factor ligand superfamily member 12; Belongs to the tumor necrosis factor family. (221 aa)
FLCNFolliculin isoform X1. (647 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
BAG6Large proline-rich protein BAG6 isoform X1. (1174 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
INCA1Protein INCA1. (260 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (131 aa)
LOC110585403Bcl-2-like protein 2. (193 aa)
INHBBInhibin beta B chain. (407 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (571 aa)
RHOT2Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (620 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
DIABLODiablo homolog, mitochondrial isoform X1. (237 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
BMI1Polycomb complex protein BMI-1 isoform X1. (326 aa)
YAP1Transcriptional coactivator YAP1. (437 aa)
BNIP3LBCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like. (219 aa)
ANXA6Annexin. (673 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (446 aa)
LOC110587203Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
BAG3BAG family molecular chaperone regulator 3 isoform X1. (578 aa)
JMYJunction-mediating and -regulatory protein. (992 aa)
DDIT4DNA damage-inducible transcript 4 protein. (231 aa)
ERCC6DNA excision repair protein ERCC-6. (1482 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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