STRINGSTRING
PCSK4 PCSK4 LRP2 LRP2 APP APP ITSN1 ITSN1 SH3BP4 SH3BP4 ACKR3 ACKR3 SGIP1 SGIP1 AP2S1 AP2S1 AP2A1 AP2A1 FURIN FURIN AP1S2 AP1S2 SPHK1 SPHK1 AP1S3 AP1S3 EPS15 EPS15 FCHO1 FCHO1 EPS15L1 EPS15L1 CDCP2 CDCP2 LOC110578886 LOC110578886 DNM1L DNM1L ADCY8 ADCY8 AP2A2 AP2A2 MYO6 MYO6 AP2M1 AP2M1 AP1S1 AP1S1 REPS1 REPS1 VLDLR VLDLR CUBN CUBN ITSN2 ITSN2 ATAT1 ATAT1 SLC18A3 SLC18A3 STON1 STON1 FCHO2 FCHO2 AP2B1 AP2B1 RAB35 RAB35
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (759 aa)
LRP2LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 2. (4645 aa)
APPAmyloid beta A4 protein isoform X1. (770 aa)
ITSN1Intersectin-1. (1220 aa)
SH3BP4SH3 domain-binding protein 4. (962 aa)
ACKR3Atypical chemokine receptor 3 isoform X1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
SGIP1SH3-containing GRB2-like protein 3-interacting protein 1. (908 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (956 aa)
FURINFurin isoform X1; Belongs to the peptidase S8 family. (795 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa)
SPHK1Sphingosine kinase 1 isoform X1. (487 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (206 aa)
EPS15Epidermal growth factor receptor substrate 15 isoform X1. (899 aa)
FCHO1F-BAR domain only protein 1 isoform X1. (941 aa)
EPS15L1Epidermal growth factor receptor substrate 15-like 1 isoform X6. (910 aa)
CDCP2CUB domain-containing protein 2. (570 aa)
LOC110578886Carbonic anhydrase 1 isoform X1; Belongs to the alpha-carbonic anhydrase family. (261 aa)
DNM1LDynamin-1-like protein isoform X4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (936 aa)
MYO6LOW QUALITY PROTEIN: unconventional myosin-VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1262 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
REPS1ralBP1-associated Eps domain-containing protein 1 isoform X1. (796 aa)
VLDLRVery low-density lipoprotein receptor isoform X1. (845 aa)
CUBNCubilin. (3620 aa)
ITSN2Intersectin-2 isoform X1. (1657 aa)
ATAT1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (333 aa)
SLC18A3Vesicular acetylcholine transporter. (517 aa)
STON1Stonin-1; Belongs to the Stoned B family. (735 aa)
FCHO2LOW QUALITY PROTEIN: F-BAR domain only protein 2. (866 aa)
AP2B1AP complex subunit beta. (951 aa)
RAB35Ras-related protein Rab-35. (221 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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