(42 nodes) SMAD/FHA domain superfamily network (Neomonachus schauinslandi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KIF1A	Kinesin-like protein KIF1A isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1784 aa)
	IRF3	Interferon regulatory factor 3 isoform X1. (458 aa)
	CEP170	Centrosomal protein of 170 kDa. (1583 aa)
	IRF6	Interferon regulatory factor 6. (462 aa)
	RASIP1	Ras-interacting protein 1. (963 aa)
	KIF14	Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
	TIFA	TRAF-interacting protein with FHA domain-containing protein A. (185 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
	PPP1R8	Nuclear inhibitor of protein phosphatase 1. (351 aa)
	SNIP1	Smad nuclear-interacting protein 1. (397 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	APTX	Aprataxin isoform X1. (342 aa)
	LOC110580224	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1000 aa)
	CHFR	E3 ubiquitin-protein ligase CHFR isoform X1. (670 aa)
	TCF19	Transcription factor 19. (345 aa)
	SLC4A1AP	Kanadaptin. (741 aa)
	IRF9	Interferon regulatory factor 9. (410 aa)
	APLF	Aprataxin and PNK-like factor. (513 aa)
	IRF7	Interferon regulatory factor 7. (496 aa)
	KIF1C	Kinesin-like protein KIF1C isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1116 aa)
	SLMAP	Sarcolemmal membrane-associated protein isoform X1. (845 aa)
	STARD9	stAR-related lipid transfer protein 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (4700 aa)
	AFDN	Afadin isoform X1. (1791 aa)
	LOC110583310	Mothers against decapentaplegic homolog. (451 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	IRF4	Interferon regulatory factor 4 isoform X2. (451 aa)
	KIF16B	Kinesin-like protein KIF16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1317 aa)
	IRF5	Interferon regulatory factor 5 isoform X1. (519 aa)
	AGGF1	Angiogenic factor with G patch and FHA domains 1. (716 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	SMAD6	Mothers against decapentaplegic homolog. (498 aa)
	TIFAB	TRAF-interacting protein with FHA domain-containing protein B. (201 aa)
	IRF8	Interferon regulatory factor 8. (426 aa)
	CHEK2	Serine/threonine-protein kinase Chk2. (544 aa)
	MKI67	LOW QUALITY PROTEIN: proliferation marker protein Ki-67. (2036 aa)
	PHF12	PHD finger protein 12 isoform X1. (1004 aa)
	MCRS1	Microspherule protein 1 isoform X1. (462 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	SMAD9	Mothers against decapentaplegic homolog. (469 aa)
	RADIL	LOW QUALITY PROTEIN: ras-associating and dilute domain-containing protein. (1054 aa)

Your Current Organism:

Neomonachus schauinslandi

NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGGF1	RADIL	A0A2Y9I131	A0A2Y9GCK5	Angiogenic factor with G patch and FHA domains 1.	LOW QUALITY PROTEIN: ras-associating and dilute domain-containing protein.	0.536
APLF	APTX	A0A2Y9HSV0	A0A2Y9H5R8	Aprataxin and PNK-like factor.	Aprataxin isoform X1.	0.741
APLF	CHFR	A0A2Y9HSV0	A0A2Y9H8J0	Aprataxin and PNK-like factor.	E3 ubiquitin-protein ligase CHFR isoform X1.	0.622
APLF	MKI67	A0A2Y9HSV0	A0A2Y9I696	Aprataxin and PNK-like factor.	LOW QUALITY PROTEIN: proliferation marker protein Ki-67.	0.611
APTX	APLF	A0A2Y9H5R8	A0A2Y9HSV0	Aprataxin isoform X1.	Aprataxin and PNK-like factor.	0.741
CHEK2	RNF8	A0A2Y9I5M3	A0A2Y9GMA1	Serine/threonine-protein kinase Chk2.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.672
CHFR	APLF	A0A2Y9H8J0	A0A2Y9HSV0	E3 ubiquitin-protein ligase CHFR isoform X1.	Aprataxin and PNK-like factor.	0.622
CHFR	MKI67	A0A2Y9H8J0	A0A2Y9I696	E3 ubiquitin-protein ligase CHFR isoform X1.	LOW QUALITY PROTEIN: proliferation marker protein Ki-67.	0.538
IRF3	IRF5	A0A2Y9GG29	A0A2Y9HYP2	Interferon regulatory factor 3 isoform X1.	Interferon regulatory factor 5 isoform X1.	0.510
IRF3	IRF7	A0A2Y9GG29	A0A2Y9HDQ1	Interferon regulatory factor 3 isoform X1.	Interferon regulatory factor 7.	0.976
IRF3	SMAD3	A0A2Y9GG29	A0A2Y9HII2	Interferon regulatory factor 3 isoform X1.	Mothers against decapentaplegic homolog.	0.436
IRF5	IRF3	A0A2Y9HYP2	A0A2Y9GG29	Interferon regulatory factor 5 isoform X1.	Interferon regulatory factor 3 isoform X1.	0.510
IRF7	IRF3	A0A2Y9HDQ1	A0A2Y9GG29	Interferon regulatory factor 7.	Interferon regulatory factor 3 isoform X1.	0.976
LOC110583310	SMAD1	A0A2Y9HI04	A0A2Y9G7S1	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.839
LOC110583310	SMAD3	A0A2Y9HI04	A0A2Y9HII2	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.965
LOC110583310	SMAD4	A0A2Y9HI04	A0A2Y9GS17	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.993
LOC110583310	SMAD5	A0A2Y9HI04	A0A2Y9I186	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.577
LOC110583310	SMAD6	A0A2Y9HI04	A0A2Y9HJN0	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.862
LOC110583310	SMAD7	A0A2Y9HI04	A0A2Y9GVZ8	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.883
LOC110583310	SMAD9	A0A2Y9HI04	A0A2Y9G876	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.586