STRINGSTRING
UBE2D1 UBE2D1 STUB1 STUB1 ZFYVE9 ZFYVE9 SKI SKI F11R F11R USP9X USP9X LDLRAD4 LDLRAD4 PPP1R15A PPP1R15A MEIS3 MEIS3 FURIN FURIN PARP1 PARP1 LTBP2 LTBP2 SMURF1 SMURF1 TGFBR2 TGFBR2 TFDP2 TFDP2 CCNK CCNK SNW1 SNW1 TGFB3 TGFB3 ITGB3 ITGB3 CDK8 CDK8 SMURF2 SMURF2 PMEPA1 PMEPA1 TRIM33 TRIM33 ATP1B4 ATP1B4 TGIF1 TGIF1 SMAD2 SMAD2 SMAD7 SMAD7 WWTR1 WWTR1 CGN CGN IRX5 IRX5 NCOR1 NCOR1 LOC110582100 LOC110582100 TGFBR1 TGFBR1 UBE2M UBE2M CDK19 CDK19 CDK9 CDK9 TGIF2LX TGIF2LX STRAP STRAP ITGB5 ITGB5 TGIF2 TGIF2 LOC110581157 LOC110581157 LOC110581116 LOC110581116 BAMBI BAMBI SP1 SP1 FKBP1A FKBP1A RBL1 RBL1 IRX2 IRX2 MAPK1 MAPK1 ITGB8 ITGB8 E2F5 E2F5 LOC110580801 LOC110580801 CCNC CCNC LOC110583310 LOC110583310 SMAD3 SMAD3 CCNT2 CCNT2 RNF111 RNF111 FBN1 FBN1 LOC110586377 LOC110586377 PCSK4 PCSK4 JUNB JUNB E2F4 E2F4 IRX3 IRX3 MTMR4 MTMR4 ITGAV ITGAV ARHGEF18 ARHGEF18 CCNT1 CCNT1 LOC110592031 LOC110592031 IRX6 IRX6 PARD6A PARD6A PPM1A PPM1A LOC110592032 LOC110592032 SKIL SKIL PARD3 PARD3 IRX4 IRX4 IRX1 IRX1 LTBP3 LTBP3 MKX MKX SMAD4 SMAD4 NEDD4L NEDD4L ITGB1 ITGB1 MEN1 MEN1 HDAC1 HDAC1 UBA52 UBA52 FAM58A FAM58A PRKCZ PRKCZ KXD1 KXD1 ITGB6 ITGB6 LOC110590956 LOC110590956 LOC110590515 LOC110590515 RPS27A RPS27A LTBP4 LTBP4 NCOR2 NCOR2 TGFB1 TGFB1 MAPK3 MAPK3 TGFB2 TGFB2 LOC110589396 LOC110589396 ITGA8 ITGA8 LTBP1 LTBP1 NEDD8 NEDD8 TFDP1 TFDP1 CBL CBL LOC110588252 LOC110588252 LOC110588689 LOC110588689
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
STUB1E3 ubiquitin-protein ligase CHIP isoform X1. (384 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1423 aa)
SKISki oncogene isoform X1. (731 aa)
F11RJunctional adhesion molecule A. (298 aa)
USP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2554 aa)
LDLRAD4Low-density lipoprotein receptor class A domain-containing protein 4 isoform X2. (306 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (553 aa)
MEIS3Homeobox protein Meis3. (378 aa)
FURINFurin isoform X1; Belongs to the peptidase S8 family. (795 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
LTBP2Latent-transforming growth factor beta-binding protein 2 isoform X1. (1827 aa)
SMURF1E3 ubiquitin-protein ligase. (731 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
TFDP2Transcription factor. (335 aa)
CCNKcyclin-K; Belongs to the cyclin family. (574 aa)
SNW1SNW domain-containing protein 1 isoform X1. (571 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
CDK8Cyclin-dependent kinase 8 isoform X1; Belongs to the protein kinase superfamily. (464 aa)
SMURF2E3 ubiquitin-protein ligase. (736 aa)
PMEPA1Protein TMEPAI isoform X1. (254 aa)
TRIM33E3 ubiquitin-protein ligase TRIM33. (1127 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (360 aa)
TGIF1Homeobox protein TGIF1. (272 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
CGNCingulin isoform X1. (1197 aa)
IRX5Iroquois-class homeodomain protein IRX-5. (483 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2458 aa)
LOC110582100Probable ubiquitin carboxyl-terminal hydrolase FAF-X. (345 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
UBE2MNEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
CDK19LOW QUALITY PROTEIN: cyclin-dependent kinase 19. (502 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
TGIF2LXHomeobox protein TGIF2LX. (215 aa)
STRAPSerine-threonine kinase receptor-associated protein. (350 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
LOC110581157Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (1504 aa)
LOC110581116Probable ubiquitin carboxyl-terminal hydrolase FAF-X. (112 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SP1Transcription factor Sp1. (786 aa)
FKBP1APeptidylprolyl isomerase. (99 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
IRX2Iroquois-class homeodomain protein IRX-2. (473 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
E2F5Transcription factor E2F5 isoform X1. (346 aa)
LOC110580801Probable ubiquitin carboxyl-terminal hydrolase FAF-Y. (228 aa)
CCNCcyclin-C; Belongs to the cyclin family. (283 aa)
LOC110583310Mothers against decapentaplegic homolog. (451 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CCNT2cyclin-T2 isoform X1; Belongs to the cyclin family. (733 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform X2. (1000 aa)
FBN1Fibrillin-1. (2868 aa)
LOC110586377ubiquitin-60S ribosomal protein L40-like. (162 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (759 aa)
JUNBTranscription factor jun-B. (347 aa)
E2F4Transcription factor E2F4 isoform X1. (399 aa)
IRX3Iroquois-class homeodomain protein IRX-3 isoform X1. (502 aa)
MTMR4Myotubularin-related protein 4 isoform X1. (1209 aa)
ITGAVIntegrin alpha-V isoform X1; Belongs to the integrin alpha chain family. (1047 aa)
ARHGEF18LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 18. (1171 aa)
CCNT1cyclin-T1; Belongs to the cyclin family. (726 aa)
LOC110592031Partitioning defective 3 homolog B-like. (333 aa)
IRX6Iroquois-class homeodomain protein IRX-6. (444 aa)
PARD6APartitioning defective 6 homolog alpha isoform X1. (346 aa)
PPM1AProtein phosphatase 1A. (382 aa)
LOC110592032Partitioning defective 3 homolog B-like. (569 aa)
SKILSki-like protein isoform X1. (684 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1359 aa)
IRX4Iroquois-class homeodomain protein IRX-4 isoform X1. (577 aa)
IRX1Iroquois-class homeodomain protein IRX-1. (392 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1298 aa)
MKXHomeobox protein Mohawk. (353 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NEDD4LE3 ubiquitin-protein ligase NEDD4-like. (975 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
MEN1Menin isoform X1. (616 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
FAM58ACyclin-related protein FAM58A isoform X1; Belongs to the cyclin family. (250 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
KXD1kxDL motif-containing protein 1. (176 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
LOC110590956ubiquitin-40S ribosomal protein S27a-like. (154 aa)
LOC110590515E3 ubiquitin-protein ligase CHIP. (303 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4. (1602 aa)
NCOR2Nuclear receptor corepressor 2 isoform X1. (2503 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
LOC110589396LOW QUALITY PROTEIN: SNW domain-containing protein 1-like. (400 aa)
ITGA8Integrin alpha-8 isoform X1; Belongs to the integrin alpha chain family. (1066 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1. (1393 aa)
NEDD8NEDD8. (81 aa)
TFDP1Transcription factor. (410 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
LOC110588252Ubiquitin. (77 aa)
LOC110588689ubiquitin-40S ribosomal protein S27a-like. (154 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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