STRINGSTRING
NRAS NRAS ERAS ERAS COL6A1 COL6A1 CASS4 CASS4 NCK1 NCK1 PIK3CB PIK3CB PDGFA PDGFA NCK2 NCK2 LOC110572955 LOC110572955 PLAT PLAT PCSK4 PCSK4 CRK CRK COL2A1 COL2A1 COL5A3 COL5A3 GRB7 GRB7 FNDC3B FNDC3B BCAR1 BCAR1 PDGFRA PDGFRA COL5A2 COL5A2 STAT1 STAT1 COL3A1 COL3A1 SPP1 SPP1 PIK3R1 PIK3R1 RASA1 RASA1 THBS4 THBS4 SOS1 SOS1 PDGFC PDGFC PTPN11 PTPN11 PDGFRB PDGFRB NEDD9 NEDD9 PDGFD PDGFD THBS1 THBS1 EFS EFS PLG PLG COL5A1 COL5A1 RAPGEF1 RAPGEF1 THBS2 THBS2 PIK3CA PIK3CA HRAS HRAS FNDC3A FNDC3A LOC110579526 LOC110579526 KRAS KRAS CSDE1 CSDE1 PDGFB PDGFB PTPN12 PTPN12 LOC110579958 LOC110579958 SRC SRC PLCG1 PLCG1 STAT6 STAT6 CRKL CRKL LOC110575329 LOC110575329 THBS3 THBS3 STAT3 STAT3 PIK3R2 PIK3R2 LOC110573272 LOC110573272 GRB2 GRB2 LOC110573273 LOC110573273 FURIN FURIN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRASGTPase NRas. (189 aa)
ERASGTPase ERas. (233 aa)
COL6A1Collagen alpha-1(VI) chain. (1027 aa)
CASS4Cas scaffolding protein family member 4. (786 aa)
NCK1Cytoplasmic protein. (377 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (331 aa)
NCK2Cytoplasmic protein. (380 aa)
LOC110572955Fibronectin type III domain containing protein 3C1-like. (1437 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (759 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
COL5A3Collagen alpha-3(V) chain. (1749 aa)
GRB7Growth factor receptor-bound protein 7. (530 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1208 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (865 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
COL5A2Collagen alpha-2(V) chain. (1499 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
SPP1Osteopontin. (272 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1039 aa)
THBS4Thrombospondin-4 isoform X1. (961 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
NEDD9Enhancer of filamentation 1. (834 aa)
PDGFDPlatelet-derived growth factor D. (335 aa)
THBS1Thrombospondin-1. (1170 aa)
EFSEmbryonal Fyn-associated substrate isoform X1. (561 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
COL5A1Collagen alpha-1(V) chain. (1138 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1025 aa)
THBS2Thrombospondin-2. (1172 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X1. (189 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1199 aa)
LOC110579526Signal transducer and activator of transcription 5A-like. (153 aa)
KRASGTPase KRas. (188 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12 isoform X1. (783 aa)
LOC110579958Signal transducer and activator of transcription 5B-like. (204 aa)
SRCTyrosine-protein kinase. (536 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
CRKLCrk-like protein. (303 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
THBS3Thrombospondin-3 isoform X1. (956 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
LOC110573272Signal transducer and activator of transcription 5A. (478 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
LOC110573273Signal transducer and activator of transcription 5B. (600 aa)
FURINFurin isoform X1; Belongs to the peptidase S8 family. (795 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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