STRINGSTRING
CSDE1 CSDE1 LOC110569887 LOC110569887 FRS2 FRS2 ERAS ERAS RPS6KA5 RPS6KA5 PIK3CB PIK3CB PPP4R4 PPP4R4 LOC110571849 LOC110571849 ELK1 ELK1 FOSB FOSB AP2S1 AP2S1 AP2A1 AP2A1 PPP2R1A PPP2R1A DUSP3 DUSP3 GRB2 GRB2 RPS6KA3 RPS6KA3 NKPD1 NKPD1 SH3GL2 SH3GL2 VRK3 VRK3 IRS1 IRS1 JUND JUND PIK3R2 PIK3R2 SHC1 SHC1 ID3 ID3 NTRK1 NTRK1 RIT1 RIT1 RPS6KA1 RPS6KA1 MAPKAPK2 MAPKAPK2 MAPK14 MAPK14 FOSL1 FOSL1 ASCL2 ASCL2 FNBP4 FNBP4 KIAA1468 KIAA1468 RIT2 RIT2 RPS6KA4 RPS6KA4 NAB2 NAB2 DUSP6 DUSP6 ASCL1 ASCL1 CRKL CRKL ARC ARC MAPK15 MAPK15 MAPKAPK3 MAPKAPK3 YWHAB YWHAB DNAL4 DNAL4 MAPK11 MAPK11 MAPK1 MAPK1 PPP4R1 PPP4R1 NGF NGF RAP1A RAP1A LOC110580711 LOC110580711 KRAS KRAS CHD4 CHD4 CLTA CLTA TRIB1 TRIB1 RALGDS RALGDS NRAS NRAS SRF SRF PPP2R5D PPP2R5D HRAS HRAS AP2A2 AP2A2 PIK3CA PIK3CA BRAF BRAF RPS6KA2 RPS6KA2 RAPGEF1 RAPGEF1 LOC110583232 LOC110583232 SHC4 SHC4 MAP2K1 MAP2K1 DUSP4 DUSP4 PPP2CB PPP2CB SHC3 SHC3 MAPK7 MAPK7 AP2M1 AP2M1 DUSP7 DUSP7 IRS2 IRS2 LOC110583655 LOC110583655 MAP2K5 MAP2K5 PPP2R1B PPP2R1B TRIB2 TRIB2 ID2 ID2 KIDINS220 KIDINS220 RALB RALB ID4 ID4 EGR4 EGR4 SOS1 SOS1 MAPK3 MAPK3 EGR3 EGR3 EGR2 EGR2 PIK3R1 PIK3R1 NAB1 NAB1 CREB1 CREB1 EGR1 EGR1 RALA RALA RRAD RRAD CLTC CLTC AP2B1 AP2B1 PPP2CA PPP2CA ATF1 ATF1 MAP2K2 MAP2K2 SHC2 SHC2 CRK CRK JUNB JUNB LYL1 LYL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
LOC110569887Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like. (767 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ERASGTPase ERas. (233 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (874 aa)
LOC110571849Insulin receptor substrate 1-like. (404 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (435 aa)
FOSBProtein fosB. (338 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (956 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (589 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
NKPD1NTPase KAP family P-loop domain-containing protein 1 isoform X1. (822 aa)
SH3GL2endophilin-A1. (317 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X1. (493 aa)
IRS1Insulin receptor substrate 1. (1236 aa)
JUNDTranscription factor jun-D. (347 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
RIT1GTP-binding protein Rit1. (219 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
MAPKAPK2MAP kinase-activated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (402 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
FOSL1Fos-related antigen 1 isoform X2. (271 aa)
ASCL2Achaete-scute homolog 2. (194 aa)
FNBP4Formin-binding protein 4. (1019 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1214 aa)
RIT2GTP-binding protein Rit2 isoform X1. (217 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
NAB2NGFI-A-binding protein 2 isoform X1. (525 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
ASCL1Achaete-scute homolog 1. (227 aa)
CRKLCrk-like protein. (303 aa)
ARCActivity-regulated cytoskeleton-associated protein. (400 aa)
MAPK15Mitogen-activated protein kinase 15. (703 aa)
MAPKAPK3MAP kinase-activated protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (384 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (244 aa)
DNAL4Dynein light chain. (105 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (937 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
LOC110580711Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (600 aa)
KRASGTPase KRas. (188 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1940 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (218 aa)
TRIB1Tribbles homolog 1 isoform X1. (375 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (886 aa)
NRASGTPase NRas. (189 aa)
SRFSerum response factor isoform X1. (508 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (676 aa)
HRASGTPase HRas isoform X1. (189 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (936 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
RPS6KA2Ribosomal protein S6 kinase. (727 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1025 aa)
LOC110583232Uncharacterized protein LOC110583232. (149 aa)
SHC4SHC-transforming protein 4. (630 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SHC3SHC-transforming protein 3. (469 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
DUSP7Dual specificity protein phosphatase 7. (270 aa)
IRS2Insulin receptor substrate 2. (1330 aa)
LOC110583655LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1-like. (445 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (693 aa)
TRIB2Tribbles homolog 2. (343 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa. (1754 aa)
RALBRas-related protein Ral-B. (206 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
EGR4LOW QUALITY PROTEIN: early growth response protein 4. (587 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
EGR3Early growth response protein 3. (387 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (484 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
NAB1NGFI-A-binding protein 1 isoform X1. (486 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
RALARas-related protein Ral-A. (206 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
AP2B1AP complex subunit beta. (951 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X1. (310 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SHC2SHC-transforming protein 2. (551 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
JUNBTranscription factor jun-B. (347 aa)
LYL1Protein lyl-1. (279 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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