STRINGSTRING
ARHGEF28 ARHGEF28 LIMK2 LIMK2 CLTB CLTB NGEF NGEF PTK2 PTK2 GRIN2B GRIN2B SDCBP2 SDCBP2 CLTCL1 CLTCL1 CLTA CLTA FNDC3A FNDC3A ARPC5L ARPC5L AP2A2 AP2A2 EPHB6 EPHB6 GRIN1 GRIN1 EPHA7 EPHA7 VAV2 VAV2 DNM1 DNM1 PAK2 PAK2 AP2M1 AP2M1 EFNB3 EFNB3 LOC110582645 LOC110582645 EPHB3 EPHB3 ACTR3B ACTR3B EFNB2 EFNB2 EFNA5 EFNA5 RASA1 RASA1 ARPC4 ARPC4 EPHA1 EPHA1 FMN1 FMN1 ARHGEF7 ARHGEF7 FYN FYN ACTR3 ACTR3 APH1B APH1B CFL2 CFL2 ACTR2 ACTR2 WASL WASL LOC110586772 LOC110586772 PSENEN PSENEN ROCK2 ROCK2 EPHA8 EPHA8 ACTL8 ACTL8 EPHB2 EPHB2 CFL1 CFL1 EPHA2 EPHA2 CDC42 CDC42 ROCK1 ROCK1 PAK3 PAK3 EPHA6 EPHA6 YES1 YES1 APH1A APH1A SDC2 SDC2 LYN LYN MMP9 MMP9 SRC SRC PAK1 PAK1 GIT1 GIT1 ARPC5 ARPC5 ACTG1 ACTG1 EFNA3 EFNA3 EFNA1 EFNA1 ACTB ACTB TIAM1 TIAM1 ITSN1 ITSN1 PTK6 PTK6 SRMS SRMS EPHB1 EPHB1 PSEN1 PSEN1 ARPC1B ARPC1B EFNB1 EFNB1 EPHB4 EPHB4 NCK2 NCK2 ARPC1A ARPC1A ELSPBP1 ELSPBP1 ACTBL2 ACTBL2 AP2B1 AP2B1 CLTC CLTC DSTN DSTN AP2A1 AP2A1 LOC110572955 LOC110572955 EFNA2 EFNA2 ARPC2 ARPC2 FNDC3B FNDC3B FMN2 FMN2 NCSTN NCSTN EPHA10 EPHA10 EFNA4 EFNA4 EPHA5 EPHA5 EPHA4 EPHA4 MMP2 MMP2 LOC110577769 LOC110577769 EPHA3 EPHA3 SDCBP SDCBP PSEN2 PSEN2 VAV3 VAV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGEF28Rho guanine nucleotide exchange factor 28. (1388 aa)
LIMK2LIM domain kinase 2 isoform X1. (631 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (211 aa)
NGEFEphexin-1. (592 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1055 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1484 aa)
SDCBP2Syntenin-2. (287 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1673 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (218 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1199 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (936 aa)
EPHB6Ephrin type-B receptor 6. (1013 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (943 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (1005 aa)
VAV2Guanine nucleotide exchange factor VAV2. (862 aa)
DNM1LOW QUALITY PROTEIN: dynamin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (867 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
EFNB3ephrin-B3; Belongs to the ephrin family. (340 aa)
LOC110582645LOW QUALITY PROTEIN: kalirin-like. (1634 aa)
EPHB3Ephrin type-B receptor 3. (959 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (418 aa)
EFNB2ephrin-B2 isoform X2; Belongs to the ephrin family. (333 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1039 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
EPHA1Ephrin type-A receptor 1 isoform X1. (976 aa)
FMN1Formin-1 isoform X1. (1419 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (646 aa)
FYNTyrosine-protein kinase. (537 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
APH1BGamma-secretase subunit APH-1B isoform X1. (257 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (505 aa)
LOC110586772Syntenin-1-like. (240 aa)
PSENENGamma-secretase subunit PEN-2. (101 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1391 aa)
EPHA8Ephrin type-A receptor 8. (991 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
EPHB2Ephrin type-B receptor 2. (963 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (219 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PAK3Non-specific serine/threonine protein kinase. (544 aa)
EPHA6Ephrin type-A receptor 6. (1130 aa)
YES1Tyrosine-protein kinase. (541 aa)
APH1AGamma-secretase subunit APH-1A. (265 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
LYNTyrosine-protein kinase. (512 aa)
MMP9Matrix metalloproteinase-9 isoform X1. (704 aa)
SRCTyrosine-protein kinase. (536 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
GIT1ARF GTPase-activating protein GIT1. (748 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
EFNA3ephrin-A3 isoform X1; Belongs to the ephrin family. (232 aa)
EFNA1ephrin-A1; Belongs to the ephrin family. (205 aa)
ACTBActin, cytoplasmic 1. (375 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1591 aa)
ITSN1Intersectin-1. (1220 aa)
PTK6Tyrosine-protein kinase. (486 aa)
SRMSTyrosine-protein kinase. (493 aa)
EPHB1Ephrin type-B receptor 1. (680 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (375 aa)
EFNB1ephrin-B1; Belongs to the ephrin family. (346 aa)
EPHB4Ephrin type-B receptor 4. (988 aa)
NCK2Cytoplasmic protein. (380 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ELSPBP1Epididymal sperm-binding protein 1. (223 aa)
ACTBL2Beta-actin-like protein 2 isoform X1. (376 aa)
AP2B1AP complex subunit beta. (951 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
DSTNDestrin; Belongs to the actin-binding proteins ADF family. (165 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (956 aa)
LOC110572955Fibronectin type III domain containing protein 3C1-like. (1437 aa)
EFNA2ephrin-A2. (164 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1208 aa)
FMN2Formin-2. (982 aa)
NCSTNNicastrin. (709 aa)
EPHA10Ephrin type-A receptor 10. (1008 aa)
EFNA4ephrin-A4; Belongs to the ephrin family. (204 aa)
EPHA5Ephrin type-A receptor 5 isoform X1. (1039 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
MMP272 kDa type IV collagenase. (661 aa)
LOC110577769Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
EPHA3Ephrin type-A receptor 3 isoform X1. (984 aa)
SDCBPSyntenin-1 isoform X1. (298 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
VAV3Guanine nucleotide exchange factor VAV3. (847 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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