STRINGSTRING
DVL1 DVL1 LRP5 LRP5 CTNNB1 CTNNB1 AMER1 AMER1 LRP5L LRP5L FZD1 FZD1 GSK3A GSK3A LRP6 LRP6 DVL3 DVL3 GSK3B GSK3B DVL2 DVL2 CAV3 CAV3 CAV1 CAV1 AXIN1 AXIN1 HMGXB3 HMGXB3 WNT8A WNT8A WNT8B WNT8B PPP2R1A PPP2R1A FZD2 FZD2 WNT1 WNT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (979 aa)
CTNNB1Catenin beta-1. (781 aa)
AMER1APC membrane recruitment protein 1. (1131 aa)
LRP5LLOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5-like protein. (453 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (648 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
AXIN1Axin-1 isoform X1. (867 aa)
HMGXB3HMG domain-containing protein 3 isoform X1. (1292 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (589 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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