STRINGSTRING
CSDE1 CSDE1 KRAS KRAS FGF4 FGF4 FRS3 FRS3 HRAS HRAS PIK3CA PIK3CA FGF23 FGF23 FGF6 FGF6 FGF20 FGF20 LOC110575329 LOC110575329 SHC1 SHC1 FGF2 FGF2 PTPN11 PTPN11 GRB2 GRB2 FGFR1 FGFR1 FLRT2 FLRT2 GAB1 GAB1 ERAS ERAS FRS2 FRS2 FGF9 FGF9 FLRT3 FLRT3 FGF8 FGF8 FGF1 FGF1 FGF10 FGF10 FGF17 FGF17 SOS1 SOS1 PIK3R1 PIK3R1 FGF3 FGF3 NRAS NRAS FGF22 FGF22 FGF5 FGF5 FLRT1 FLRT1 PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FRS3Fibroblast growth factor receptor substrate 3. (458 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (374 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGFR1Fibroblast growth factor receptor. (735 aa)
FLRT2Leucine-rich repeat transmembrane protein FLRT2. (660 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
ERASGTPase ERas. (233 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3. (649 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
NRASGTPase NRas. (189 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
FLRT1Leucine-rich repeat transmembrane protein FLRT1. (674 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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