STRINGSTRING
NRAS NRAS FRS3 FRS3 GRB2 GRB2 FRS2 FRS2 FGF17 FGF17 SOS1 SOS1 FGF8 FGF8 HRAS HRAS FGF23 FGF23 FGF6 FGF6 FGF20 FGF20 PTPN11 PTPN11 FGF10 FGF10 FGF1 FGF1 ERAS ERAS FGF22 FGF22 FGF5 FGF5 FGF9 FGF9 FGF2 FGF2 KRAS KRAS CSDE1 CSDE1 FGF4 FGF4 FGF3 FGF3 LOC110575329 LOC110575329 FGFR1 FGFR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRASGTPase NRas. (189 aa)
FRS3Fibroblast growth factor receptor substrate 3. (458 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
HRASGTPase HRas isoform X1. (189 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ERASGTPase ERas. (233 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (374 aa)
KRASGTPase KRas. (188 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
FGFR1Fibroblast growth factor receptor. (735 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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