STRINGSTRING
FGF4 FGF4 FGFRL1 FGFRL1 FGF9 FGF9 FRS2 FRS2 ERAS ERAS GAB1 GAB1 FLRT2 FLRT2 LOC110572955 LOC110572955 FGFR1 FGFR1 GRB2 GRB2 FGF2 FGF2 SHC1 SHC1 LOC110575329 LOC110575329 UBA52 UBA52 FGF3 FGF3 MKNK1 MKNK1 FLRT1 FLRT1 PLCG1 PLCG1 SRC SRC MAPK1 MAPK1 CSDE1 CSDE1 KRAS KRAS FNDC3A FNDC3A NRAS NRAS FRS3 FRS3 HRAS HRAS PIK3CA PIK3CA FGF23 FGF23 BRAF BRAF FGF6 FGF6 PPP2CB PPP2CB FGF20 FGF20 SPRED1 SPRED1 LOC110586377 LOC110586377 SPRY2 SPRY2 CBL CBL FGF18 FGF18 PTPN11 PTPN11 LOC110588252 LOC110588252 FGF10 FGF10 FGF17 FGF17 LOC110588689 LOC110588689 SOS1 SOS1 SPRED2 SPRED2 FGF8 FGF8 MAPK3 MAPK3 ANOS1 ANOS1 RPS27A RPS27A FGF1 FGF1 PIK3R1 PIK3R1 FLRT3 FLRT3 FGF5 FGF5 PPP2CA PPP2CA FNDC3B FNDC3B MKNK2 MKNK2 FGF22 FGF22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (494 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ERASGTPase ERas. (233 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
FLRT2Leucine-rich repeat transmembrane protein FLRT2. (660 aa)
LOC110572955Fibronectin type III domain containing protein 3C1-like. (1437 aa)
FGFR1Fibroblast growth factor receptor. (735 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (374 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (418 aa)
FLRT1Leucine-rich repeat transmembrane protein FLRT1. (674 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
SRCTyrosine-protein kinase. (536 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1199 aa)
NRASGTPase NRas. (189 aa)
FRS3Fibroblast growth factor receptor substrate 3. (458 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (442 aa)
LOC110586377ubiquitin-60S ribosomal protein L40-like. (162 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
LOC110588252Ubiquitin. (77 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
LOC110588689ubiquitin-40S ribosomal protein S27a-like. (154 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
SPRED2Sprouty-related, EVH1 domain-containing protein 2. (417 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ANOS1Anosmin-1 isoform X1. (680 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3. (649 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1208 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1. (586 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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