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POLR2L POLR2L FGF9 FGF9 FRS2 FRS2 ERAS ERAS GAB1 GAB1 FGFBP1 FGFBP1 LOC110572955 LOC110572955 GRB2 GRB2 FGF2 FGF2 SHC1 SHC1 LOC110575329 LOC110575329 UBA52 UBA52 FGF3 FGF3 MKNK1 MKNK1 POLR2G POLR2G FGF4 FGF4 RBFOX2 RBFOX2 POLR2F POLR2F FGF16 FGF16 POLR2K POLR2K PLCG1 PLCG1 SRC SRC MAPK1 MAPK1 PTBP2 PTBP2 CSDE1 CSDE1 KRAS KRAS ESRP1 ESRP1 FNDC3A FNDC3A PTBP3 PTBP3 NRAS NRAS FRS3 FRS3 HRAS HRAS POLR2H POLR2H PIK3CA PIK3CA FGF23 FGF23 BRAF BRAF FGF6 FGF6 FGF7 FGF7 PPP2CB PPP2CB NCBP1 NCBP1 FGF20 FGF20 POLR2A POLR2A NCBP2 NCBP2 POLR2D POLR2D LOC110586377 LOC110586377 GTF2F2 GTF2F2 SPRY2 SPRY2 CBL CBL FGF18 FGF18 PTPN11 PTPN11 LOC110588252 LOC110588252 FGF10 FGF10 FGF17 FGF17 LOC110588689 LOC110588689 SOS1 SOS1 TIAL1 TIAL1 MAPK3 MAPK3 POLR2J POLR2J TIA1 TIA1 POLR2I POLR2I RPS27A RPS27A POLR2B POLR2B FGF1 FGF1 FGFBP3 FGFBP3 PIK3R1 PIK3R1 FGFR2 FGFR2 PPP2CA PPP2CA POLR2E POLR2E FNDC3B FNDC3B MKNK2 MKNK2 ESRP2 ESRP2 POLR2C POLR2C GTF2F1 GTF2F1 FGF22 FGF22 HNRNPM HNRNPM PTBP1 PTBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLR2LDNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ERASGTPase ERas. (233 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (255 aa)
LOC110572955Fibronectin type III domain containing protein 3C1-like. (1437 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (374 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (418 aa)
POLR2GDNA-directed RNA polymerase II subunit RPB7. (172 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
RBFOX2RNA binding protein fox-1 homolog; RNA-binding protein that regulates alternative splicing events. (377 aa)
POLR2FDNA-directed RNA polymerases I, II, and III subunit RPABC2. (127 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
POLR2KDNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
SRCTyrosine-protein kinase. (536 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
PTBP2Polypyrimidine tract-binding protein 2 isoform X1. (503 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
ESRP1Epithelial splicing regulatory protein 1 isoform X1. (681 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1199 aa)
PTBP3Polypyrimidine tract-binding protein 3 isoform X1. (545 aa)
NRASGTPase NRas. (189 aa)
FRS3Fibroblast growth factor receptor substrate 3. (458 aa)
HRASGTPase HRas isoform X1. (189 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
NCBP1Nuclear cap-binding protein subunit 1 isoform X3. (790 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1925 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
POLR2DDNA-directed RNA polymerase II subunit RPB4. (142 aa)
LOC110586377ubiquitin-60S ribosomal protein L40-like. (162 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
LOC110588252Ubiquitin. (77 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
LOC110588689ubiquitin-40S ribosomal protein S27a-like. (154 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
TIAL1Nucleolysin TIAR isoform X1. (392 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
POLR2JDNA-directed RNA polymerase II subunit RPB11-a. (117 aa)
TIA1Nucleolysin TIA-1 isoform X1. (395 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGFBP3Fibroblast growth factor-binding protein 3. (261 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FGFR2Fibroblast growth factor receptor. (842 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
POLR2EDNA-directed RNA polymerases I, II, and III subunit RPABC1. (210 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1208 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1. (586 aa)
ESRP2Epithelial splicing regulatory protein 2 isoform X1. (717 aa)
POLR2CDNA-directed RNA polymerase II subunit RPB3. (275 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
HNRNPMHeterogeneous nuclear ribonucleoprotein M isoform X1. (763 aa)
PTBP1Polypyrimidine tract-binding protein 1 isoform X1. (557 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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