STRINGSTRING
HGFAC HGFAC RAP1B RAP1B ERAS ERAS GAB1 GAB1 DOCK7 DOCK7 SH3GL3 SH3GL3 HGS HGS GGA3 GGA3 LOC110572955 LOC110572955 GRB2 GRB2 SH3GL2 SH3GL2 LAMC2 LAMC2 PTPN2 PTPN2 SHC1 SHC1 STAT3 STAT3 SH3KBP1 SH3KBP1 LAMB3 LAMB3 LAMC1 LAMC1 EPS15 EPS15 LOC110575329 LOC110575329 COL11A2 COL11A2 LAMB1 LAMB1 PTPRJ PTPRJ UBA52 UBA52 ITGB1 ITGB1 LAMA1 LAMA1 LAMB2 LAMB2 PTPN1 PTPN1 CRKL CRKL SRC SRC LOC110578735 LOC110578735 CSDE1 CSDE1 RAP1A RAP1A COL11A1 COL11A1 COL24A1 COL24A1 PTK2 PTK2 KRAS KRAS FNDC3A FNDC3A LAMC3 LAMC3 HGF HGF NRAS NRAS HRAS HRAS PIK3CA PIK3CA RAB4A RAB4A RAPGEF1 RAPGEF1 LAMA2 LAMA2 COL5A1 COL5A1 LAMA4 LAMA4 MUC20 MUC20 LOC110582902 LOC110582902 LRIG1 LRIG1 SPINT1 SPINT1 USP8 USP8 MEGF11 MEGF11 LOC110586377 LOC110586377 RANBP9 RANBP9 CBL CBL PTPN11 PTPN11 LOC110588252 LOC110588252 STAM STAM LOC110588689 LOC110588689 SOS1 SOS1 MET MET ITGA2 ITGA2 RPS27A RPS27A PIK3R1 PIK3R1 HPN HPN RAB4B RAB4B TNS1 TNS1 COL3A1 COL3A1 SPINT2 SPINT2 FN1 FN1 COL5A2 COL5A2 TNS3 TNS3 ARF6 ARF6 ITGA3 ITGA3 FNDC3B FNDC3B STAM2 STAM2 RANBP10 RANBP10 COL5A3 COL5A3 COL2A1 COL2A1 CRK CRK TNS4 TNS4 SH3GL1 SH3GL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HGFACHepatocyte growth factor activator. (473 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
ERASGTPase ERas. (233 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
DOCK7Dedicator of cytokinesis protein 7; Belongs to the DOCK family. (2129 aa)
SH3GL3endophilin-A3. (278 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (781 aa)
GGA3LOW QUALITY PROTEIN: ADP-ribosylation factor-binding protein GGA3. (729 aa)
LOC110572955Fibronectin type III domain containing protein 3C1-like. (1437 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SH3GL2endophilin-A1. (317 aa)
LAMC2Laminin subunit gamma-2 isoform X1. (1191 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1. (667 aa)
LAMB3Laminin subunit beta-3 isoform X1. (1191 aa)
LAMC1Laminin subunit gamma-1. (1529 aa)
EPS15Epidermal growth factor receptor substrate 15 isoform X1. (899 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
COL11A2Collagen alpha-2(XI) chain. (1736 aa)
LAMB1LOW QUALITY PROTEIN: laminin subunit beta-1. (1838 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta. (1089 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
LAMA1LOW QUALITY PROTEIN: laminin subunit alpha-1. (3077 aa)
LAMB2Laminin subunit beta-2. (1801 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (453 aa)
CRKLCrk-like protein. (303 aa)
SRCTyrosine-protein kinase. (536 aa)
LOC110578735Collagen alpha-1(V) chain-like. (218 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
COL11A1Collagen alpha-1(XI) chain. (1818 aa)
COL24A1Collagen alpha-1(XXIV) chain. (1695 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1055 aa)
KRASGTPase KRas. (188 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1199 aa)
LAMC3Laminin subunit gamma-3. (1576 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
NRASGTPase NRas. (189 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAB4ARas-related protein Rab-4A isoform X1. (218 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1025 aa)
LAMA2Laminin subunit alpha-2. (3088 aa)
COL5A1Collagen alpha-1(V) chain. (1138 aa)
LAMA4Laminin subunit alpha-4. (1824 aa)
MUC20Mucin-20. (534 aa)
LOC110582902Hepatocyte growth factor activator-like; Belongs to the peptidase S1 family. (169 aa)
LRIG1Leucine-rich repeats and immunoglobulin-like domains protein 1. (1102 aa)
SPINT1Kunitz-type protease inhibitor 1 isoform X1. (511 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1116 aa)
MEGF11Multiple epidermal growth factor-like domains protein 11. (1044 aa)
LOC110586377ubiquitin-60S ribosomal protein L40-like. (162 aa)
RANBP9Ran-binding protein 9 isoform X2. (499 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
LOC110588252Ubiquitin. (77 aa)
STAMSignal transducing adapter molecule 1. (536 aa)
LOC110588689ubiquitin-40S ribosomal protein S27a-like. (154 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
METHepatocyte growth factor receptor. (1382 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1105 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
HPNSerine protease hepsin isoform X1; Belongs to the peptidase S1 family. (432 aa)
RAB4BRas-related protein Rab-4B. (213 aa)
TNS1Tensin-1. (1796 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
SPINT2Kunitz-type protease inhibitor 2 isoform X1. (274 aa)
FN1Fibronectin isoform X7. (2476 aa)
COL5A2Collagen alpha-2(V) chain. (1499 aa)
TNS3Tensin-3. (1310 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ITGA3LOW QUALITY PROTEIN: integrin alpha-3; Belongs to the integrin alpha chain family. (1050 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1208 aa)
STAM2Signal transducing adapter molecule 2. (525 aa)
RANBP10Ran-binding protein 10 isoform X2. (619 aa)
COL5A3Collagen alpha-3(V) chain. (1749 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
TNS4Tensin-4 isoform X1. (707 aa)
SH3GL1endophilin-A2. (368 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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