STRINGSTRING
LOC110570219 LOC110570219 FGFR3 FGFR3 ERAS ERAS PRKCA PRKCA GAB1 GAB1 PIK3CB PIK3CB PDGFA PDGFA EIF4E EIF4E ARAF ARAF IGF1R IGF1R AKT1 AKT1 BAX BAX JAK1 JAK1 IL6R IL6R GRB2 GRB2 RPS6 RPS6 FGF2 FGF2 AKT3 AKT3 EIF4EBP1 EIF4EBP1 PIK3R2 PIK3R2 SHC1 SHC1 STAT3 STAT3 PRKCG PRKCG EGF EGF RPS6KB2 RPS6KB2 MTOR MTOR PIK3R3 PIK3R3 PIK3CD PIK3CD BCL2 BCL2 PPP1R14B PPP1R14B BAD BAD ERBB3 ERBB3 PRKCB PRKCB PLCG1 PLCG1 SRC SRC MAPK1 MAPK1 IL6 IL6 IGF1 IGF1 PDGFB PDGFB CSDE1 CSDE1 KRAS KRAS BCL2L1 BCL2L1 HGF HGF NRAS NRAS HRAS HRAS LOC110582265 LOC110582265 PIK3CA PIK3CA GSK3B GSK3B BRAF BRAF EIF4E2 EIF4E2 FOXO3 FOXO3 VEGFA VEGFA CEP152 CEP152 SHC4 SHC4 MAP2K1 MAP2K1 SHC3 SHC3 NRG1 NRG1 JAK2 JAK2 RAF1 RAF1 EIF4E1B EIF4E1B GAS6 GAS6 PDGFD PDGFD PDGFRB PDGFRB BCL2L11 BCL2L11 PTEN PTEN PDGFC PDGFC SOS1 SOS1 TGFA TGFA MET MET MAPK3 MAPK3 AXL AXL SOS2 SOS2 KDR KDR NRG2 NRG2 PIK3R1 PIK3R1 TBCA TBCA AKT2 AKT2 PDGFRA PDGFRA EGFR EGFR FGFR2 FGFR2 ERBB2 ERBB2 NF1 NF1 MAP2K2 MAP2K2 SHC2 SHC2 RPS6KB1 RPS6KB1 PLCG2 PLCG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC110570219Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (470 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
ERASGTPase ERas. (233 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (331 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
JAK1Tyrosine-protein kinase. (1156 aa)
IL6RInterleukin-6 receptor subunit alpha. (483 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (374 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
SRCTyrosine-protein kinase. (536 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
IL6Interleukin-6 isoform X1. (212 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
NRASGTPase NRas. (189 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC11058226540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
FOXO3Forkhead box protein O3. (672 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (549 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
SHC4SHC-transforming protein 4. (630 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SHC3SHC-transforming protein 3. (469 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (857 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (263 aa)
GAS6Growth arrest-specific protein 6. (674 aa)
PDGFDPlatelet-derived growth factor D. (335 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (131 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
TGFAProtransforming growth factor alpha. (160 aa)
METHepatocyte growth factor receptor. (1382 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
AXLTyrosine-protein kinase receptor UFO isoform X1. (887 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X2. (853 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (129 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
FGFR2Fibroblast growth factor receptor. (842 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
NF1Neurofibromin isoform X1. (2841 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SHC2SHC-transforming protein 2. (551 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1200 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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