STRINGSTRING
MAPK1 MAPK1 MAPK11 MAPK11 NCOA3 NCOA3 SRC SRC MMP9 MMP9 JAG1 JAG1 SP1 SP1 MAPK12 MAPK12 BIK BIK CCND1 CCND1 CDK4 CDK4 CDKN1C CDKN1C BAD BAD PPP1R14B PPP1R14B BCL2 BCL2 PIK3CD PIK3CD PIK3R3 PIK3R3 MTOR MTOR CDKN2C CDKN2C RPS6KB2 RPS6KB2 CDKN1A CDKN1A MAPK14 MAPK14 MAPK13 MAPK13 JUN JUN E2F2 E2F2 SHC1 SHC1 PIK3R2 PIK3R2 NOTCH3 NOTCH3 AKT3 AKT3 GRB2 GRB2 BAX BAX AKT1 AKT1 IGF1R IGF1R ARAF ARAF GPER1 GPER1 JAG2 JAG2 PIK3CB PIK3CB FOS FOS MDM2 MDM2 ERAS ERAS LOC110569839 LOC110569839 GNAS GNAS CARM1 CARM1 PRKACA PRKACA RPS6KB1 RPS6KB1 SHC2 SHC2 ADCY1 ADCY1 ADCY6 ADCY6 MAP2K2 MAP2K2 ADCY7 ADCY7 MMP2 MMP2 ERBB2 ERBB2 MED1 MED1 EGFR EGFR AKT2 AKT2 ESR2 ESR2 ABCB11 ABCB11 ADCY2 ADCY2 LOC110591392 LOC110591392 LOC110591391 LOC110591391 PIK3R1 PIK3R1 HBEGF HBEGF LOC110590588 LOC110590588 SOS2 SOS2 DLL3 DLL3 MAPK3 MAPK3 MAPK8 MAPK8 ADCY9 ADCY9 PTRHD1 PTRHD1 SOS1 SOS1 GPSM3 GPSM3 NOTCH4 NOTCH4 E2F3 E2F3 MMP20 MMP20 ADCY3 ADCY3 LOC110584335 LOC110584335 ADCY4 ADCY4 DLL4 DLL4 CCDC170 CCDC170 RAF1 RAF1 TP53 TP53 NCOR1 NCOR1 SHC3 SHC3 MAP2K1 MAP2K1 SHC4 SHC4 CEP152 CEP152 ESR1 ESR1 DLL1 DLL1 NOTCH1 NOTCH1 CDKN1B CDKN1B BRAF BRAF PRKACB PRKACB ADCY5 ADCY5 PIK3CA PIK3CA EYS EYS HRAS HRAS NRAS NRAS E2F1 E2F1 ADCY8 ADCY8 KRAS KRAS PTK2 PTK2 NOTCH2 NOTCH2 CSDE1 CSDE1 MAPK9 MAPK9 IGF1 IGF1 RB1 RB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
NCOA3Nuclear receptor coactivator. (1402 aa)
SRCTyrosine-protein kinase. (536 aa)
MMP9Matrix metalloproteinase-9 isoform X1. (704 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SP1Transcription factor Sp1. (786 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
BIKBcl-2-interacting killer. (165 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (263 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
E2F2Transcription factor E2F2. (449 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
NOTCH3Neurogenic locus notch homolog protein 3 isoform X1. (2322 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1154 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSProto-oncogene c-Fos. (380 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
ERASGTPase ERas. (233 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
CARM1Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (572 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
SHC2SHC-transforming protein 2. (551 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
MMP272 kDa type IV collagenase. (661 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ESR2Estrogen receptor beta isoform X1. (530 aa)
ABCB11Bile salt export pump isoform X1. (1325 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
LOC110590588Coiled-coil domain-containing protein 170-like. (607 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
DLL3LOW QUALITY PROTEIN: delta-like protein 3. (639 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
GPSM3G-protein-signaling modulator 3. (162 aa)
NOTCH4Neurogenic locus notch homolog protein 4. (1996 aa)
E2F3Transcription factor E2F3 isoform X1. (466 aa)
MMP20Matrix metalloproteinase-20. (483 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
LOC110584335Histone-arginine methyltransferase CARM1-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (409 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
CCDC170Coiled-coil domain-containing protein 170. (716 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2458 aa)
SHC3SHC-transforming protein 3. (469 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2567 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EYSLOW QUALITY PROTEIN: protein eyes shut homolog. (595 aa)
HRASGTPase HRas isoform X1. (189 aa)
NRASGTPase NRas. (189 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
KRASGTPase KRas. (188 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1055 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2471 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
RB1Retinoblastoma-associated protein. (934 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.