STRINGSTRING
JUN JUN PRKCG PRKCG EGF EGF CDKN1A CDKN1A RPS6KB2 RPS6KB2 MTOR MTOR PIK3R3 PIK3R3 PIK3CD PIK3CD PPP1R14B PPP1R14B CAMK2D CAMK2D PAK3 PAK3 BAD BAD PIK3CB PIK3CB NCK2 NCK2 PLCG2 PLCG2 MAP2K7 MAP2K7 CRK CRK RPS6KB1 RPS6KB1 SHC2 SHC2 MAP2K2 MAP2K2 EPGN EPGN PAK1 PAK1 ERBB2 ERBB2 RRAD RRAD AREG AREG EGFR EGFR CAMK2B CAMK2B AKT2 AKT2 TMEFF2 TMEFF2 PAK4 PAK4 ERBB4 ERBB4 BTC BTC EREG EREG NCK1 NCK1 LOC110591392 LOC110591392 ALKBH4 ALKBH4 LOC110591391 LOC110591391 PIK3R1 PIK3R1 NRG2 NRG2 HBEGF HBEGF NRG3 NRG3 SOS2 SOS2 MAPK3 MAPK3 MAPK8 MAPK8 CAMK2G CAMK2G ARSI ARSI TGFA TGFA SOS1 SOS1 CBL CBL REM2 REM2 CAMK2A CAMK2A MAP2K4 MAP2K4 NRG4 NRG4 PAK6 PAK6 RAF1 RAF1 PAK2 PAK2 NRG1 NRG1 SHC3 SHC3 MAP2K1 MAP2K1 SHC4 SHC4 CEP152 CEP152 CDKN1B CDKN1B BRAF BRAF GSK3B GSK3B CBLB CBLB PIK3CA PIK3CA HRAS HRAS NRAS NRAS REM1 REM1 MSANTD3 MSANTD3 LOC110581473 LOC110581473 ABL1 ABL1 LOC110579526 LOC110579526 PAK5 PAK5 GEM GEM KRAS KRAS PTK2 PTK2 CSDE1 CSDE1 MAPK9 MAPK9 LOC110579958 LOC110579958 MAPK1 MAPK1 SRC SRC PLCG1 PLCG1 PRKCB PRKCB ERBB3 ERBB3 MYC MYC CRKL CRKL ELK3 ELK3 CDKN1C CDKN1C GAB1 GAB1 PRKCA PRKCA ERAS ERAS ARAF ARAF ELK1 ELK1 AKT1 AKT1 LOC110573273 LOC110573273 GRB2 GRB2 ABL2 ABL2 AKT3 AKT3 LOC110573272 LOC110573272 EIF4EBP1 EIF4EBP1 PIK3R2 PIK3R2 SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4. (525 aa)
PAK3Non-specific serine/threonine protein kinase. (544 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
NCK2Cytoplasmic protein. (380 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1200 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (440 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
SHC2SHC-transforming protein 2. (551 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
EPGNEpigen isoform X1. (153 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
AREGAmphiregulin. (253 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (651 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TMEFF2Tomoregulin-2. (374 aa)
PAK4Non-specific serine/threonine protein kinase. (594 aa)
ERBB4Receptor protein-tyrosine kinase. (1270 aa)
BTCProbetacellulin. (178 aa)
EREGProepiregulin. (308 aa)
NCK1Cytoplasmic protein. (377 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
ALKBH4Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4. (302 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X2. (853 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform. (674 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (606 aa)
ARSIArylsulfatase I. (575 aa)
TGFAProtransforming growth factor alpha. (160 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (126 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (857 aa)
SHC3SHC-transforming protein 3. (469 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X1. (189 aa)
NRASGTPase NRas. (189 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
MSANTD3myb/SANT-like DNA-binding domain-containing protein 3. (275 aa)
LOC110581473Tomoregulin-1. (380 aa)
ABL1Tyrosine-protein kinase. (1137 aa)
LOC110579526Signal transducer and activator of transcription 5A-like. (153 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
KRASGTPase KRas. (188 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1055 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC110579958Signal transducer and activator of transcription 5B-like. (204 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
SRCTyrosine-protein kinase. (536 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
CRKLCrk-like protein. (303 aa)
ELK3ETS domain-containing protein Elk-3 isoform X1. (402 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (263 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ERASGTPase ERas. (233 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (435 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC110573273Signal transducer and activator of transcription 5B. (600 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC110573272Signal transducer and activator of transcription 5A. (478 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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