STRINGSTRING
LDHB LDHB FLT1 FLT1 IFNG IFNG LOC110570737 LOC110570737 IFNGR2 IFNGR2 LOC110570839 LOC110570839 PGK1 PGK1 LOC110569916 LOC110569916 PFKL PFKL PRKCA PRKCA PIK3CB PIK3CB LOC110571646 LOC110571646 LOC110571842 LOC110571842 ZAN ZAN EPO EPO EIF4E EIF4E PDHA2 PDHA2 IGF1R IGF1R AKT1 AKT1 NFKB1 NFKB1 XK XK IL6R IL6R RPS6 RPS6 TEK TEK AKT3 AKT3 LTF LTF EIF4EBP1 EIF4EBP1 LOC110573186 LOC110573186 PIK3R2 PIK3R2 STAT3 STAT3 PRKCG PRKCG SLC2A1 SLC2A1 EGF EGF CDKN1A CDKN1A RELA RELA RPS6KB2 RPS6KB2 PDHA1 PDHA1 NPPA NPPA ENO1 ENO1 MTOR MTOR LDHA LDHA PIK3R3 PIK3R3 MKNK1 MKNK1 PIK3CD PIK3CD LOC110576815 LOC110576815 LOC110575364 LOC110575364 BCL2 BCL2 CAMK2D CAMK2D LDHC LDHC CDKN1C CDKN1C INS INS CUL2 CUL2 ARNT ARNT ANGPT1 ANGPT1 PRKCB PRKCB EP300 EP300 PLCG1 PLCG1 HMOX1 HMOX1 MAPK1 MAPK1 RBX1 RBX1 IL6 IL6 IGF1 IGF1 ELOC ELOC ANGPT4 ANGPT4 LTBR LTBR PFKP PFKP TLR4 TLR4 LOC110582265 LOC110582265 PIK3CA PIK3CA TFRC TFRC GAPDH GAPDH EIF4E2 EIF4E2 CDKN1B CDKN1B ENO2 ENO2 NOS3 NOS3 TIMP1 TIMP1 LOC110583041 LOC110583041 ALDOB ALDOB VEGFA VEGFA MAP2K1 MAP2K1 PGK2 PGK2 ANGPT2 ANGPT2 ENO3 ENO3 SERPINE1 SERPINE1 VHL VHL IFNGR1 IFNGR1 EIF4E1B EIF4E1B EGLN3 EGLN3 PFKFB3 PFKFB3 EDN1 EDN1 CAMK2A CAMK2A PDHB PDHB EGLN1 EGLN1 LOC110588028 LOC110588028 ELOB ELOB CREBBP CREBBP HK2 HK2 ARSI ARSI HKDC1 HKDC1 ENO4 ENO4 CAMK2G CAMK2G HK1 HK1 MAPK3 MAPK3 HK3 HK3 FCGBP FCGBP EGLN2 EGLN2 LOC110590435 LOC110590435 LOC110590663 LOC110590663 PIK3R1 PIK3R1 TBCA TBCA PDK1 PDK1 ALDOA ALDOA AKT2 AKT2 CAMK2B CAMK2B HIF1A HIF1A EGFR EGFR ERBB2 ERBB2 MAP2K2 MAP2K2 MKNK2 MKNK2 RPS6KB1 RPS6KB1 NOS2 NOS2 ALDOC ALDOC PFKM PFKM INSR INSR PLCG2 PLCG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC110570737Inhibitor of carbonic anhydrase-like isoform X1; Belongs to the transferrin family. (699 aa)
IFNGR2Interferon gamma receptor 2 isoform X1. (356 aa)
LOC110570839LOW QUALITY PROTEIN: serotransferrin-like. (998 aa)
PGK1Phosphoglycerate kinase. (417 aa)
LOC110569916Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC110571646Glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
LOC110571842L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
ZANLOW QUALITY PROTEIN: zonadhesin. (2782 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
XKXK-related protein. (444 aa)
IL6RInterleukin-6 receptor subunit alpha. (483 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
TEKAngiopoietin-1 receptor. (1124 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LTFLactotransferrin isoform X1; Belongs to the transferrin family. (708 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
LOC110573186Cytochrome b-245 heavy chain. (570 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (501 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
RELATranscription factor p65. (531 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
NPPANatriuretic peptides A. (152 aa)
ENO1Alpha-enolase. (434 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (418 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC110576815Glyceraldehyde-3-phosphate dehydrogenase. (310 aa)
LOC110575364Glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (212 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4. (525 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (263 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CUL2Cullin-2 isoform X1; Belongs to the cullin family. (745 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (786 aa)
ANGPT1Angiopoietin-1 isoform X2. (498 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
IL6Interleukin-6 isoform X1. (212 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
ELOCelongin-C isoform X1; Belongs to the SKP1 family. (148 aa)
ANGPT4Angiopoietin-4. (498 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (421 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (790 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
LOC11058226540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TFRCTransferrin receptor protein 1 isoform X1. (770 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
ENO2Gamma-enolase. (434 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
TIMP1Metalloproteinase inhibitor 1. (159 aa)
LOC110583041L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (375 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (549 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PGK2Phosphoglycerate kinase. (417 aa)
ANGPT2Angiopoietin-2. (541 aa)
ENO3Beta-enolase isoform X1. (478 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
VHLVon Hippel-Lindau disease tumor suppressor. (219 aa)
IFNGR1LOW QUALITY PROTEIN: interferon gamma receptor 1. (474 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (263 aa)
EGLN3Egl nine homolog 3. (239 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1. (519 aa)
EDN1Endothelin-1. (202 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
EGLN1Egl nine homolog 1. (425 aa)
LOC110588028L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (344 aa)
ELOBelongin-B. (118 aa)
CREBBPCREB-binding protein isoform X3. (2433 aa)
HK2Hexokinase-2. (917 aa)
ARSIArylsulfatase I. (575 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (917 aa)
ENO4Enolase 4. (624 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (606 aa)
HK1Hexokinase-1. (917 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
HK3Hexokinase-3. (924 aa)
FCGBPIgGFc-binding protein. (3005 aa)
EGLN2Egl nine homolog 2 isoform X1. (474 aa)
LOC110590435L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (274 aa)
LOC110590663Glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (129 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (651 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1. (586 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (853 aa)
INSRTyrosine-protein kinase receptor. (1368 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1200 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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