STRINGSTRING
MAPK3 MAPK3 TGFB1 TGFB1 SOS2 SOS2 RASL11B RASL11B SIRT1 SIRT1 PIK3R1 PIK3R1 LOC110591391 LOC110591391 ATG12 ATG12 CCNG2 CCNG2 LOC110591392 LOC110591392 PLK2 PLK2 CNTD2 CNTD2 CCNB1 CCNB1 G6PC2 G6PC2 AKT2 AKT2 BNIP3 BNIP3 EGFR EGFR NLK NLK RRAD RRAD RASGEF1B RASGEF1B TNFSF10 TNFSF10 MAP2K2 MAP2K2 PRKAB1 PRKAB1 CDKN2D CDKN2D PLK5 PLK5 S1PR4 S1PR4 STK11 STK11 PRKAG3 PRKAG3 RBL2 RBL2 GABARAPL2 GABARAPL2 PRKAG1 PRKAG1 PCK1 PCK1 PMEPA1 PMEPA1 RNF6 RNF6 FOXO1 FOXO1 LOC110570219 LOC110570219 SLC35E3 SLC35E3 IRS4 IRS4 ERAS ERAS SETD7 SETD7 MDM2 MDM2 TGFB3 TGFB3 PIK3CB PIK3CB CCNB3 CCNB3 GADD45A GADD45A LOC110571849 LOC110571849 TGFBR2 TGFBR2 FOXO4 FOXO4 ARAF ARAF IGF1R IGF1R CDK3 CDK3 AKT1 AKT1 PRMT1 PRMT1 PLK4 PLK4 IKBKB IKBKB G6PC3 G6PC3 HOMER2 HOMER2 GRB2 GRB2 LOC110572649 LOC110572649 SNAPIN SNAPIN IL10 IL10 G6PC G6PC AKT3 AKT3 IRS1 IRS1 LDLRAD4 LDLRAD4 HOMER3 HOMER3 KLF2 KLF2 TSSK6 TSSK6 PIK3R2 PIK3R2 STAT3 STAT3 PRKAA2 PRKAA2 SUCO SUCO FOXJ3 FOXJ3 FASLG FASLG EGF EGF MAPK13 MAPK13 MAPK14 MAPK14 CDKN1A CDKN1A RAG1 RAG1 PLK3 PLK3 MYO9B MYO9B PIK3R3 PIK3R3 PIK3CD PIK3CD TSSK3 TSSK3 SMAD4 SMAD4 FOXO6 FOXO6 RAG2 RAG2 PLK1 PLK1 CDKN1C CDKN1C INS INS PRMT3 PRMT3 CDK2 CDK2 AGAP2 AGAP2 CAT CAT LOC110577932 LOC110577932 CCND1 CCND1 MAPK12 MAPK12 PRKAB2 PRKAB2 LOC110579077 LOC110579077 FBXO32 FBXO32 EP300 EP300 SGK2 SGK2 STK4 STK4 MAPK11 MAPK11 MAPK1 MAPK1 IL6 IL6 IGF1 IGF1 MAPK9 MAPK9 PIK3CA PIK3CA S1PR1 S1PR1 CSDE1 CSDE1 CCND2 CCND2 KRAS KRAS GEM GEM FOXJ2 FOXJ2 PRMT8 PRMT8 TSSK1B TSSK1B LOC110579201 LOC110579201 REM1 REM1 NRAS NRAS HRAS HRAS BRAF BRAF GADD45B GADD45B INSR INSR BCL6 BCL6 CDKN1B CDKN1B PRKAG2 PRKAG2 SOD2 SOD2 LOC110583232 LOC110583232 GABARAPL1 GABARAPL1 TSSK2 TSSK2 GRM1 GRM1 FOXO3 FOXO3 CCNB2 CCNB2 TGFBR1 TGFBR1 MAP2K1 MAP2K1 GADD45G GADD45G BCL6B BCL6B GRAP GRAP GABARAP GABARAP RAF1 RAF1 PCK2 PCK2 FOXG1 FOXG1 TMEM232 TMEM232 SMAD3 SMAD3 IRS2 IRS2 LOC110583655 LOC110583655 RNF111 RNF111 MYO9A MYO9A SKP2 SKP2 FBXO25 FBXO25 PRKAA1 PRKAA1 SLC2A4 SLC2A4 BCL2L11 BCL2L11 TSSK4 TSSK4 REM2 REM2 PDPK1 PDPK1 IL7R IL7R PTEN PTEN ATM ATM CREBBP CREBBP USP7 USP7 SOS1 SOS1 CHUK CHUK HOMER1 HOMER1 TGFB2 TGFB2 RASGEF1A RASGEF1A MAPK8 MAPK8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
RASL11BRas-like protein family member 11B. (248 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (746 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
CCNG2cyclin-G2; Belongs to the cyclin family. (343 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
CNTD2Cyclin N-terminal domain-containing protein 2; Belongs to the cyclin family. (329 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
NLKSerine/threonine-protein kinase NLK. (306 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
RASGEF1BLOW QUALITY PROTEIN: ras-GEF domain-containing family member 1B. (472 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (286 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
PLK5LOW QUALITY PROTEIN: inactive serine/threonine-protein kinase PLK5. (452 aa)
S1PR4Sphingosine 1-phosphate receptor 4. (385 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (596 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (485 aa)
RBL2Retinoblastoma-like protein 2 isoform X1. (1139 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (622 aa)
PMEPA1Protein TMEPAI isoform X1. (254 aa)
RNF6E3 ubiquitin-protein ligase RNF6. (683 aa)
FOXO1Forkhead box protein O1. (663 aa)
LOC110570219Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (470 aa)
SLC35E3Solute carrier family 35 member E3 isoform X1. (313 aa)
IRS4Insulin receptor substrate 4. (1244 aa)
ERASGTPase ERas. (233 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1324 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
LOC110571849Insulin receptor substrate 1-like. (404 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
FOXO4Forkhead box protein O4. (506 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CDK3Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (452 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRMT1Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
PLK4Serine/threonine-protein kinase PLK4. (970 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
HOMER2Homer protein homolog 2. (279 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
LOC110572649Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
SNAPINSNARE-associated protein Snapin. (137 aa)
IL10Interleukin-10. (178 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IRS1Insulin receptor substrate 1. (1236 aa)
LDLRAD4Low-density lipoprotein receptor class A domain-containing protein 4 isoform X2. (306 aa)
HOMER3Homer protein homolog 3 isoform X1. (323 aa)
KLF2Krueppel-like factor 2. (357 aa)
TSSK6Testis-specific serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (273 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SUCOSUN domain-containing ossification factor. (1442 aa)
FOXJ3Forkhead box protein J3. (607 aa)
FASLGTumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (281 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
PLK3Serine/threonine-protein kinase PLK. (646 aa)
MYO9BUnconventional myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2154 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TSSK3Testis-specific serine/threonine-protein kinase 3. (268 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FOXO6Forkhead box protein O6. (527 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (263 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PRMT3Protein arginine N-methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (529 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (1197 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
LOC110577932Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (431 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
LOC110579077Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
FBXO32F-box only protein 32. (355 aa)
EP300Histone acetyltransferase p300. (2420 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
IL6Interleukin-6 isoform X1. (212 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
KRASGTPase KRas. (188 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
FOXJ2Forkhead box protein J2. (582 aa)
PRMT8Protein arginine N-methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
TSSK1BTestis-specific serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (367 aa)
LOC110579201LOW QUALITY PROTEIN: testis-specific serine/threonine-protein kinase 5-like. (347 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
NRASGTPase NRas. (189 aa)
HRASGTPase HRas isoform X1. (189 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
INSRTyrosine-protein kinase receptor. (1368 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (568 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
LOC110583232Uncharacterized protein LOC110583232. (149 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (133 aa)
TSSK2Testis-specific serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (357 aa)
GRM1Metabotropic glutamate receptor 1 isoform X1. (1190 aa)
FOXO3Forkhead box protein O3. (672 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (397 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma isoform X1. (175 aa)
BCL6BB-cell CLL/lymphoma 6 member B protein. (358 aa)
GRAPGRB2-related adapter protein. (217 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
FOXG1Forkhead box protein G1. (489 aa)
TMEM232Transmembrane protein 232. (705 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
IRS2Insulin receptor substrate 2. (1330 aa)
LOC110583655LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1-like. (445 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform X2. (1000 aa)
MYO9AUnconventional myosin-IXa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2558 aa)
SKP2S-phase kinase-associated protein 2 isoform X1. (436 aa)
FBXO25F-box only protein 25 isoform X3. (366 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (131 aa)
TSSK4Testis-specific serine/threonine-protein kinase 4; Belongs to the protein kinase superfamily. (329 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (571 aa)
IL7RInterleukin-7 receptor subunit alpha. (457 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
CREBBPCREB-binding protein isoform X3. (2433 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1102 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
HOMER1Homer protein homolog 1. (354 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
RASGEF1Aras-GEF domain-containing family member 1A. (480 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (24%) [HD]