STRINGSTRING
GEM GEM BCL2L13 BCL2L13 STK35 STK35 BCL2L1 BCL2L1 REM1 REM1 E2F1 E2F1 NRAS NRAS TFEB TFEB TAX1BP1 TAX1BP1 LOC110582118 LOC110582118 HRAS HRAS PGAM5 PGAM5 SQSTM1 SQSTM1 MFN1 MFN1 GABARAPL1 GABARAPL1 CITED2 CITED2 PRKN PRKN FOXO3 FOXO3 TP53 TP53 UBB UBB GABARAP GABARAP LOC110582911 LOC110582911 ATG9B ATG9B METTL17 METTL17 NPAS3 NPAS3 ATG5 ATG5 USP8 USP8 LOC110586377 LOC110586377 OPTN OPTN LY6G5B LY6G5B MITF MITF ULK1 ULK1 RAB7A RAB7A EIF2AK3 EIF2AK3 REM2 REM2 RHOT2 RHOT2 LOC110588252 LOC110588252 USP43 USP43 BNIP3L BNIP3L CSNK2B CSNK2B LOC110588689 LOC110588689 MAPK8 MAPK8 LOC110589957 LOC110589957 TFEC TFEC RPS27A RPS27A RASL11B RASL11B LOC110591391 LOC110591391 LOC110591392 LOC110591392 ATG9A ATG9A BNIP3 BNIP3 HIF1A HIF1A RRAD RRAD USP32 USP32 CALCOCO2 CALCOCO2 GABARAPL2 GABARAPL2 USP30 USP30 RHOT1 RHOT1 CSNK2A2 CSNK2A2 TBC1D15 TBC1D15 TBK1 TBK1 USP15 USP15 ERAS ERAS MRAS MRAS AGFG2 AGFG2 USP11 USP11 RRAS RRAS TBC1D17 TBC1D17 BECN1 BECN1 FUNDC1 FUNDC1 HIF3A HIF3A FUNDC2 FUNDC2 NPAS1 NPAS1 BECN2 BECN2 AGFG1 AGFG1 NBR1 NBR1 PDIK1L PDIK1L RIT1 RIT1 CITED4 CITED4 JUN JUN MFN2 MFN2 SPEN SPEN RELA RELA UBA52 UBA52 PINK1 PINK1 AMBRA1 AMBRA1 RIT2 RIT2 USP31 USP31 USP4 USP4 RRAS2 RRAS2 RAB7B RAB7B USP19 USP19 SP1 SP1 CSNK2A1 CSNK2A1 ATF4 ATF4 SRC SRC TOMM7 TOMM7 MAPK9 MAPK9 CSDE1 CSDE1 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
BCL2L13Bcl-2-like protein 13 isoform X1. (475 aa)
STK35Serine/threonine-protein kinase 35. (538 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
NRASGTPase NRas. (189 aa)
TFEBTranscription factor EB isoform X1. (471 aa)
TAX1BP1Tax1-binding protein 1 isoform X1. (817 aa)
LOC110582118BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1. (223 aa)
HRASGTPase HRas isoform X1. (189 aa)
PGAM5Serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1. (289 aa)
SQSTM1Sequestosome-1. (439 aa)
MFN1Mitofusin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (742 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (133 aa)
CITED2LOW QUALITY PROTEIN: cbp/p300-interacting transactivator 2. (272 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
FOXO3Forkhead box protein O3. (672 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
UBBLOW QUALITY PROTEIN: polyubiquitin-B. (156 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
LOC110582911Transcription factor E3. (229 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (920 aa)
METTL17Methyltransferase-like protein 17, mitochondrial isoform X1. (464 aa)
NPAS3Neuronal PAS domain-containing protein 3. (934 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1116 aa)
LOC110586377ubiquitin-60S ribosomal protein L40-like. (162 aa)
OPTNOptineurin isoform X1. (574 aa)
LY6G5BLymphocyte antigen 6 complex locus protein G5b. (195 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (504 aa)
ULK1Serine/threonine-protein kinase ULK1. (1054 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1114 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
RHOT2Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (620 aa)
LOC110588252Ubiquitin. (77 aa)
USP43LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family. (1023 aa)
BNIP3LBCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like. (219 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
LOC110588689ubiquitin-40S ribosomal protein S27a-like. (154 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LOC110589957Mitochondrial fission 1 protein isoform X1. (191 aa)
TFECTranscription factor EC. (347 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
RASL11BRas-like protein family member 11B. (248 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (855 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
USP32LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 32; Belongs to the peptidase C19 family. (1589 aa)
CALCOCO2Calcium-binding and coiled-coil domain-containing protein 2. (449 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (519 aa)
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (704 aa)
CSNK2A2Casein kinase II subunit alpha. (213 aa)
TBC1D15TBC1 domain family member 15 isoform X7. (691 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
ERASGTPase ERas. (233 aa)
MRASRas-related protein M-Ras. (132 aa)
AGFG2arf-GAP domain and FG repeat-containing protein 2. (490 aa)
USP11LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 11; Belongs to the peptidase C19 family. (905 aa)
RRASRas-related protein R-Ras isoform X1. (218 aa)
TBC1D17TBC1 domain family member 17 isoform X1. (652 aa)
BECN1Beclin-1 isoform X1. (448 aa)
FUNDC1FUN14 domain-containing protein 1. (155 aa)
HIF3AHypoxia-inducible factor 3-alpha isoform X1. (669 aa)
FUNDC2FUN14 domain-containing protein 2. (185 aa)
NPAS1Neuronal PAS domain-containing protein 1. (593 aa)
BECN2Beclin-2. (432 aa)
AGFG1arf-GAP domain and FG repeat-containing protein 1 isoform X1. (586 aa)
NBR1Next to BRCA1 gene 1 protein. (948 aa)
PDIK1LSerine/threonine-protein kinase PDIK1L; Belongs to the protein kinase superfamily. (341 aa)
RIT1GTP-binding protein Rit1. (219 aa)
CITED4Cbp/p300-interacting transactivator 4. (187 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
MFN2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
SPENMsx2-interacting protein. (3657 aa)
RELATranscription factor p65. (531 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial isoform X1. (583 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1182 aa)
RIT2GTP-binding protein Rit2 isoform X1. (217 aa)
USP31Ubiquitin carboxyl-terminal hydrolase 31; Belongs to the peptidase C19 family. (1282 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (964 aa)
RRAS2Ras-related protein R-Ras2. (127 aa)
RAB7BRas-related protein Rab-7b. (200 aa)
USP19Ubiquitin carboxyl-terminal hydrolase 19 isoform X1. (1350 aa)
SP1Transcription factor Sp1. (786 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (398 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
SRCTyrosine-protein kinase. (536 aa)
TOMM7Mitochondrial import receptor subunit TOM7 homolog. (55 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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