STRINGSTRING
RPTOR RPTOR DAPK3 DAPK3 UVRAG UVRAG ATG4D ATG4D ATG101 ATG101 MTMR4 MTMR4 DUS2 DUS2 GABARAPL2 GABARAPL2 TANK TANK VMP1 VMP1 PRKACA PRKACA RPS6KB1 RPS6KB1 STK11 STK11 CRYBB3 CRYBB3 RHEBL1 RHEBL1 MAP2K2 MAP2K2 ATG16L2 ATG16L2 PPP2CA PPP2CA RRAD RRAD PRAP1 PRAP1 HIF1A HIF1A BNIP3 BNIP3 KIAA1671 KIAA1671 MTMR3 MTMR3 AKT2 AKT2 CFLAR CFLAR ATG9A ATG9A LOC110591392 LOC110591392 ATG12 ATG12 LOC110591391 LOC110591391 PIK3R1 PIK3R1 WDR41 WDR41 RASL11B RASL11B RRAGB RRAGB ATG14 ATG14 ATG10 ATG10 ARID4A ARID4A MAPK3 MAPK3 MLST8 MLST8 MAPK8 MAPK8 DDIT4 DDIT4 NRBF2 NRBF2 VAMP8 VAMP8 HMGB2 HMGB2 CTSB CTSB RAB39A RAB39A CAMKK2 CAMKK2 TSC2 TSC2 KCNK1 KCNK1 LAMP1 LAMP1 PTEN PTEN PDPK1 PDPK1 RUBCNL RUBCNL REM2 REM2 TSSK4 TSSK4 EIF2AK3 EIF2AK3 ATG7 ATG7 RAB7A RAB7A ULK1 ULK1 PRKCQ PRKCQ PRKAA1 PRKAA1 IRS2 IRS2 EIF2AK4 EIF2AK4 ATG5 ATG5 RRAGD RRAGD NPAS3 NPAS3 ATG9B ATG9B LOC110582885 LOC110582885 RAB43 RAB43 RAF1 RAF1 RHEB RHEB ITPR1 ITPR1 PRKCD PRKCD MTMR14 MTMR14 GABARAP GABARAP ULK2 ULK2 TTC14 TTC14 SMCR8 SMCR8 RUBCN RUBCN PPP2CB PPP2CB MAP2K1 MAP2K1 DAPK2 DAPK2 STX17 STX17 MAP3K7 MAP3K7 LOC110583436 LOC110583436 TSSK2 TSSK2 GABARAPL1 GABARAPL1 RAB19 RAB19 CRYGN CRYGN IFITM10 IFITM10 PRKACB PRKACB SH3GLB1 SH3GLB1 ATG3 ATG3 LMLN LMLN SQSTM1 SQSTM1 PIK3CA PIK3CA HRAS HRAS NRAS NRAS REM1 REM1 BCL2L1 BCL2L1 TSC1 TSC1 STK35 STK35 LOC110579201 LOC110579201 SNAP47 SNAP47 TSSK1B TSSK1B GEM GEM KRAS KRAS RB1CC1 RB1CC1 CSDE1 CSDE1 SNAP29 SNAP29 MAPK9 MAPK9 ZFYVE28 ZFYVE28 MAPK1 MAPK1 NOL4L NOL4L TP53INP2 TP53INP2 DEPTOR DEPTOR NOL4 NOL4 TP53INP1 TP53INP1 RAB7B RAB7B RRAS2 RRAS2 RAB33A RAB33A TRAF6 TRAF6 INS INS LOC110577702 LOC110577702 BAD BAD ERN2 ERN2 LAMP2 LAMP2 PPP1R14B PPP1R14B BCL2 BCL2 PIK3C3 PIK3C3 RIT2 RIT2 AMBRA1 AMBRA1 TSSK3 TSSK3 PIK3CD PIK3CD PIK3R3 PIK3R3 RRAGC RRAGC ATG2A ATG2A ATG13 ATG13 MTOR MTOR RPS6KB2 RPS6KB2 HMGB4 HMGB4 RRAGA RRAGA PRKAA2 PRKAA2 RAB39B RAB39B RIT1 RIT1 PDIK1L PDIK1L HMGB3 HMGB3 PIK3R2 PIK3R2 TSSK6 TSSK6 IRS1 IRS1 BECN2 BECN2 AKT3 AKT3 NPAS1 NPAS1 HIF3A HIF3A LOC110572711 LOC110572711 PRKX PRKX BECN1 BECN1 DDIT4L DDIT4L RRAS RRAS AKT1 AKT1 CUNH9orf72 CUNH9orf72 ATG4C ATG4C ATG2B ATG2B IGF1R IGF1R EIF2S1 EIF2S1 RAB33B RAB33B IGBP1 IGBP1 WIPI2 WIPI2 PIK3R4 PIK3R4 LOC110571849 LOC110571849 ATG16L1 ATG16L1 ZFYVE1 ZFYVE1 PIK3CB PIK3CB ERN1 ERN1 MRAS MRAS HMGB1 HMGB1 WIPI1 WIPI1 LOC110569944 LOC110569944 ATG4B ATG4B ERAS ERAS RASEF RASEF IRS4 IRS4 TBK1 TBK1 ATG4A ATG4A SUPT20H SUPT20H LOC110570219 LOC110570219 DAPK1 DAPK1 LOC110569942 LOC110569942 LOC110569925 LOC110569925
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPTORRegulatory-associated protein of mTOR. (1335 aa)
DAPK3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
UVRAGUV radiation resistance-associated gene protein. (699 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (473 aa)
ATG101Autophagy-related protein 101. (218 aa)
MTMR4Myotubularin-related protein 4 isoform X1. (1209 aa)
DUS2tRNA-dihydrouridine(20) synthase [NAD(P)+]-like. (493 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X1. (479 aa)
VMP1Vacuole membrane protein 1 isoform X1. (406 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (596 aa)
CRYBB3Beta-crystallin B3; Belongs to the beta/gamma-crystallin family. (211 aa)
RHEBL1GTPase RhebL1. (183 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ATG16L2Autophagy-related protein 16-2 isoform X3. (620 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
PRAP1Proline-rich acidic protein 1. (156 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
KIAA1671LOW QUALITY PROTEIN: uncharacterized protein KIAA1671 homolog. (1827 aa)
MTMR3Myotubularin-related protein 3 isoform X1. (1211 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (482 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (855 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
WDR41WD repeat-containing protein 41 isoform X1. (459 aa)
RASL11BRas-like protein family member 11B. (248 aa)
RRAGBRas-related GTP-binding protein B isoform X3. (374 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (492 aa)
ATG10Ubiquitin-like-conjugating enzyme ATG10 isoform X1. (221 aa)
ARID4AAT-rich interactive domain-containing protein 4A. (1257 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X1. (346 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
DDIT4DNA damage-inducible transcript 4 protein. (231 aa)
NRBF2Nuclear receptor-binding factor 2 isoform X1. (288 aa)
VAMP8Vesicle-associated membrane protein 8. (101 aa)
HMGB2High mobility group protein B2. (210 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
RAB39ARas-related protein Rab-39A. (217 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (578 aa)
TSC2Tuberin isoform X1. (1789 aa)
KCNK1Potassium channel subfamily K member. (326 aa)
LAMP1Lysosome-associated membrane glycoprotein 1 isoform X1. (413 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (571 aa)
RUBCNLProtein RUBCNL-like isoform X1. (654 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
TSSK4Testis-specific serine/threonine-protein kinase 4; Belongs to the protein kinase superfamily. (329 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1114 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (703 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
ULK1Serine/threonine-protein kinase ULK1. (1054 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
IRS2Insulin receptor substrate 2. (1330 aa)
EIF2AK4eIF-2-alpha kinase GCN2. (1653 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
RRAGDRas-related GTP-binding protein D. (396 aa)
NPAS3Neuronal PAS domain-containing protein 3. (934 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (920 aa)
LOC110582885Cathepsin E-like. (174 aa)
RAB43Ras-related protein Rab-43 isoform X1. (212 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
RHEBGTP-binding protein Rheb. (184 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
MTMR14Myotubularin-related protein 14 isoform X1. (648 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
ULK2Serine/threonine-protein kinase ULK2. (1041 aa)
TTC14Tetratricopeptide repeat protein 14. (769 aa)
SMCR8Guanine nucleotide exchange protein SMCR8. (937 aa)
RUBCNRun domain Beclin-1-interacting and cysteine-rich domain-containing protein. (1013 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DAPK2Death-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (365 aa)
STX17Syntaxin-17; Belongs to the syntaxin family. (302 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LOC110583436Cathepsin L1-like; Belongs to the peptidase C1 family. (218 aa)
TSSK2Testis-specific serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (357 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (133 aa)
RAB19Ras-related protein Rab-19. (217 aa)
CRYGNGamma-crystallin N; Belongs to the beta/gamma-crystallin family. (183 aa)
IFITM10Interferon-induced transmembrane protein 10. (176 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
SH3GLB1endophilin-B1. (364 aa)
ATG3Autophagy-related protein 3. (314 aa)
LMLNLeishmanolysin-like peptidase. (692 aa)
SQSTM1Sequestosome-1. (439 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X1. (189 aa)
NRASGTPase NRas. (189 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
TSC1Hamartin. (1168 aa)
STK35Serine/threonine-protein kinase 35. (538 aa)
LOC110579201LOW QUALITY PROTEIN: testis-specific serine/threonine-protein kinase 5-like. (347 aa)
SNAP47Synaptosomal-associated protein 47. (415 aa)
TSSK1BTestis-specific serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (367 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
KRASGTPase KRas. (188 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
SNAP29Synaptosomal-associated protein 29. (261 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ZFYVE28Lateral signaling target protein 2 homolog. (112 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
NOL4LNucleolar protein 4-like. (606 aa)
TP53INP2Tumor protein p53-inducible nuclear protein 2. (221 aa)
DEPTORDEP domain-containing mTOR-interacting protein isoform X1. (409 aa)
NOL4Nucleolar protein 4 isoform X1. (638 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform X2. (239 aa)
RAB7BRas-related protein Rab-7b. (200 aa)
RRAS2Ras-related protein R-Ras2. (127 aa)
RAB33ARas-related protein Rab-33A. (237 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC110577702Proline-rich AKT1 substrate 1. (126 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (926 aa)
LAMP2Lysosome-associated membrane glycoprotein 2 isoform X1. (411 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
RIT2GTP-binding protein Rit2 isoform X1. (217 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1182 aa)
TSSK3Testis-specific serine/threonine-protein kinase 3. (268 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
RRAGCRas-related GTP-binding protein C. (399 aa)
ATG2AAutophagy-related protein 2 homolog A. (1924 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
HMGB4High mobility group protein B4. (192 aa)
RRAGARas-related GTP-binding protein A. (313 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
RAB39BRas-related protein Rab-39B. (213 aa)
RIT1GTP-binding protein Rit1. (219 aa)
PDIK1LSerine/threonine-protein kinase PDIK1L; Belongs to the protein kinase superfamily. (341 aa)
HMGB3High mobility group protein B3. (201 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
TSSK6Testis-specific serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (273 aa)
IRS1Insulin receptor substrate 1. (1236 aa)
BECN2Beclin-2. (432 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NPAS1Neuronal PAS domain-containing protein 1. (593 aa)
HIF3AHypoxia-inducible factor 3-alpha isoform X1. (669 aa)
LOC110572711Proline-rich AKT1 substrate 1-like. (173 aa)
PRKXcAMP-dependent protein kinase catalytic subunit PRKX; Belongs to the protein kinase superfamily. (361 aa)
BECN1Beclin-1 isoform X1. (448 aa)
DDIT4LDNA damage-inducible transcript 4-like protein. (193 aa)
RRASRas-related protein R-Ras isoform X1. (218 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CUNH9orf72Guanine nucleotide exchange C9orf72 homolog isoform X1. (481 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
ATG2BAutophagy-related protein 2 homolog B. (2077 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
RAB33BRas-related protein Rab-33B. (225 aa)
IGBP1Immunoglobulin-binding protein 1 isoform X1. (340 aa)
WIPI2WD repeat domain phosphoinositide-interacting protein 2 isoform X1. (436 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
LOC110571849Insulin receptor substrate 1-like. (404 aa)
ATG16L1Autophagy-related protein 16-1 isoform X1. (607 aa)
ZFYVE1Zinc finger FYVE domain-containing protein 1. (787 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa)
MRASRas-related protein M-Ras. (132 aa)
HMGB1High mobility group protein B1. (215 aa)
WIPI1WD repeat domain phosphoinositide-interacting protein 1. (446 aa)
LOC110569944Cathepsin L1-like; Belongs to the peptidase C1 family. (333 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (406 aa)
ERASGTPase ERas. (233 aa)
RASEFRas and EF-hand domain-containing protein. (737 aa)
IRS4Insulin receptor substrate 4. (1244 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
SUPT20HTranscription factor SPT20 homolog isoform X3. (811 aa)
LOC110570219Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (470 aa)
DAPK1Death-associated protein kinase 1. (1370 aa)
LOC110569942Cathepsin L1-like isoform X1; Belongs to the peptidase C1 family. (335 aa)
LOC110569925Cathepsin L1; Belongs to the peptidase C1 family. (334 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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