STRINGSTRING
LOC110583219 LOC110583219 INSR INSR PRKAG1 PRKAG1 ATG101 ATG101 ATF2 ATF2 PRKACA PRKACA RPS6KB1 RPS6KB1 PRKAG3 PRKAG3 STK11 STK11 CREB3L3 CREB3L3 ADCY1 ADCY1 ADCY6 ADCY6 PRKAB1 PRKAB1 RHEBL1 RHEBL1 ADCY7 ADCY7 AKT2 AKT2 CREB1 CREB1 ADCY2 ADCY2 TBCA TBCA PIK3R1 PIK3R1 SIRT1 SIRT1 CAMK4 CAMK4 ADCY9 ADCY9 PTRHD1 PTRHD1 ATF6B ATF6B CAMKK2 CAMKK2 TSC2 TSC2 ADCY3 ADCY3 ULK1 ULK1 EHMT2 EHMT2 PRKAA1 PRKAA1 IRS2 IRS2 EIF4E1B EIF4E1B ATG5 ATG5 ADCY4 ADCY4 PPARG PPARG SESN1 SESN1 RHEB RHEB APPL1 APPL1 TP53 TP53 ADIPOQ ADIPOQ FOXO3 FOXO3 SOD2 SOD2 PRKAG2 PRKAG2 CREB3L2 CREB3L2 EIF4E2 EIF4E2 PRKACB PRKACB ADCY5 ADCY5 PIK3CA PIK3CA HRAS HRAS NRAS NRAS TSC1 TSC1 CREB3 CREB3 EHMT1 EHMT1 ADCY8 ADCY8 ADIPOR2 ADIPOR2 KRAS KRAS RB1CC1 RB1CC1 CSDE1 CSDE1 CREB5 CREB5 IGF1 IGF1 ATF4 ATF4 PRKAB2 PRKAB2 CAT CAT INS INS LOC110577702 LOC110577702 PIK3CD PIK3CD PIK3R3 PIK3R3 ATG13 ATG13 MTOR MTOR RPS6KB2 RPS6KB2 RELA RELA CREB3L1 CREB3L1 PRKAA2 PRKAA2 SESN2 SESN2 PIK3R2 PIK3R2 EIF4EBP1 EIF4EBP1 IRS1 IRS1 AKT3 AKT3 LOC110572711 LOC110572711 CREB3L4 CREB3L4 RPTOR RPTOR NFKB1 NFKB1 BAX BAX AKT1 AKT1 IGF1R IGF1R PPARGC1A PPARGC1A EIF4E EIF4E LOC110571849 LOC110571849 PIK3CB PIK3CB SESN3 SESN3 ERAS ERAS IRS4 IRS4 FOXO1 FOXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC110583219Adiponectin receptor protein 1. (159 aa)
INSRTyrosine-protein kinase receptor. (1368 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
ATG101Autophagy-related protein 101. (218 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (485 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (596 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
RHEBL1GTPase RhebL1. (183 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (129 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (746 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (470 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (578 aa)
TSC2Tuberin isoform X1. (1789 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ULK1Serine/threonine-protein kinase ULK1. (1054 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform X1. (1268 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
IRS2Insulin receptor substrate 2. (1330 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (263 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (542 aa)
SESN1Sestrin-1. (492 aa)
RHEBGTP-binding protein Rheb. (184 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (708 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ADIPOQAdiponectin. (244 aa)
FOXO3Forkhead box protein O3. (672 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (568 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X1. (189 aa)
NRASGTPase NRas. (189 aa)
TSC1Hamartin. (1168 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
EHMT1Histone-lysine N-methyltransferase EHMT1. (1264 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
KRASGTPase KRas. (188 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC110577702Proline-rich AKT1 substrate 1. (126 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
RELATranscription factor p65. (531 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SESN2Sestrin-2. (481 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
IRS1Insulin receptor substrate 1. (1236 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC110572711Proline-rich AKT1 substrate 1-like. (173 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
LOC110571849Insulin receptor substrate 1-like. (404 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SESN3Sestrin-3. (414 aa)
ERASGTPase ERas. (233 aa)
IRS4Insulin receptor substrate 4. (1244 aa)
FOXO1Forkhead box protein O1. (663 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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