STRINGSTRING
ADCY6 ADCY6 PRKAB1 PRKAB1 ADCY7 ADCY7 HSPA6 HSPA6 FOXA2 FOXA2 SIRT1 SIRT1 EIF4EBP2 EIF4EBP2 PIK3R1 PIK3R1 ADCY2 ADCY2 HSPA2 HSPA2 FOXA1 FOXA1 AKT2 AKT2 CLPB CLPB ATG5 ATG5 IRS2 IRS2 HDAC2 HDAC2 CRYAB CRYAB PRKAA1 PRKAA1 LOC110586857 LOC110586857 ADCY3 ADCY3 KCNK1 KCNK1 TIMM8B TIMM8B ADCY1 ADCY1 HSPA8 HSPA8 HSPA1A HSPA1A PIK3R3 PIK3R3 HDAC1 HDAC1 MTOR MTOR RPS6KB2 RPS6KB2 PRKAA2 PRKAA2 PIK3R2 PIK3R2 IRS1 IRS1 AKT3 AKT3 LOC110572711 LOC110572711 RPTOR RPTOR AKT1 AKT1 IGF1R IGF1R LOC110571849 LOC110571849 PIK3CB PIK3CB SOD3 SOD3 ERAS ERAS IRS4 IRS4 FOXO1 FOXO1 PTRHD1 PTRHD1 ADCY9 ADCY9 PRKACA PRKACA RPS6KB1 RPS6KB1 PRKAG3 PRKAG3 INSR INSR PRKAG1 PRKAG1 PIK3CD PIK3CD LOC110577702 LOC110577702 INS INS CAT CAT SOD1 SOD1 TIMM8A TIMM8A ADCY4 ADCY4 FOXO3 FOXO3 PRKAG2 PRKAG2 SOD2 SOD2 PRKACB PRKACB ADCY5 ADCY5 PIK3CA PIK3CA HRAS HRAS NRAS NRAS ADCY8 ADCY8 KRAS KRAS CSDE1 CSDE1 IGF1 IGF1 PRKAB2 PRKAB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
HSPA6LOW QUALITY PROTEIN: heat shock 70 kDa protein 6. (381 aa)
FOXA2LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-beta. (464 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (746 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E-binding protein 2. (120 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (636 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (471 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CLPBCaseinolytic peptidase B protein homolog. (677 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
IRS2Insulin receptor substrate 2. (1330 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
LOC110586857Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
KCNK1Potassium channel subfamily K member. (326 aa)
TIMM8BMitochondrial import inner membrane translocase subunit Tim8 B; Belongs to the small Tim family. (83 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
HSPA8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (646 aa)
HSPA1AHeat shock 70 kDa protein 1A; Belongs to the heat shock protein 70 family. (641 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
IRS1Insulin receptor substrate 1. (1236 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC110572711Proline-rich AKT1 substrate 1-like. (173 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LOC110571849Insulin receptor substrate 1-like. (404 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (247 aa)
ERASGTPase ERas. (233 aa)
IRS4Insulin receptor substrate 4. (1244 aa)
FOXO1Forkhead box protein O1. (663 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (485 aa)
INSRTyrosine-protein kinase receptor. (1368 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC110577702Proline-rich AKT1 substrate 1. (126 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
TIMM8AMitochondrial import inner membrane translocase subunit Tim8 A; Belongs to the small Tim family. (103 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
FOXO3Forkhead box protein O3. (672 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (568 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X1. (189 aa)
NRASGTPase NRas. (189 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
KRASGTPase KRas. (188 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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