(71 nodes) Notch signaling pathway network (Neomonachus schauinslandi)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	MFNG	Beta-1,3-N-acetylglucosaminyltransferase. (321 aa)
	VWDE	Von Willebrand factor D and EGF domain-containing protein. (1706 aa)
	TLE1	Transducin-like enhancer protein 1 isoform X1. (780 aa)
	HEY1	Hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1. (304 aa)
	PTPRA	Receptor-type tyrosine-protein phosphatase alpha. (807 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	RBPJL	Recombining binding protein suppressor of hairless-like protein. (517 aa)
	EP300	Histone acetyltransferase p300. (2420 aa)
	APH1A	Gamma-secretase subunit APH-1A. (265 aa)
	AES	Amino-terminal enhancer of split. (119 aa)
	DTX3	Probable E3 ubiquitin-protein ligase DTX3. (353 aa)
	HDAC1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
	DTX4	E3 ubiquitin-protein ligase DTX4. (619 aa)
	DVL1	Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
	HEYL	Hairy/enhancer-of-split related with YRPW motif-like protein. (328 aa)
	NCSTN	Nicastrin. (709 aa)
	HES5	Transcription factor HES-5. (165 aa)
	NOTCH3	Neurogenic locus notch homolog protein 3 isoform X1. (2322 aa)
	RFNG	beta-1,3-N-acetylglucosaminyltransferase radical fringe. (316 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	LFNG	Beta-1,3-N-acetylglucosaminyltransferase. (345 aa)
	MAML3	Mastermind-like protein 3. (1108 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1154 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
	NUMB	Protein numb homolog isoform X1. (653 aa)
	SNW1	SNW domain-containing protein 1 isoform X1. (571 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (787 aa)
	RBPJ	Recombining binding protein suppressor of hairless. (487 aa)
	MAML2	Mastermind-like protein 2. (1118 aa)
	CTBP1	C-terminal-binding protein 1 isoform X1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (430 aa)
	BPTF	Nucleosome-remodeling factor subunit BPTF. (2842 aa)
	ATXN1L	Ataxin-1-like. (688 aa)
	CTBP2	C-terminal-binding protein 2 isoform X1. (979 aa)
	TLE6	Transducin-like enhancer protein 6. (602 aa)
	TLE2	Transducin-like enhancer protein 2 isoform X2. (689 aa)
	PTPRE	Receptor-type tyrosine-protein phosphatase. (642 aa)
	CIR1	Corepressor interacting with RBPJ 1. (463 aa)
	DTX2	Probable E3 ubiquitin-protein ligase DTX2 isoform X1. (619 aa)
	NUMBL	Numb-like protein isoform X1. (590 aa)
	PSENEN	Gamma-secretase subunit PEN-2. (101 aa)
	DLL3	LOW QUALITY PROTEIN: delta-like protein 3. (639 aa)
	NCOR2	Nuclear receptor corepressor 2 isoform X1. (2503 aa)
	LOC110589396	LOW QUALITY PROTEIN: SNW domain-containing protein 1-like. (400 aa)
	ATXN1	Ataxin-1. (808 aa)
	GPSM3	G-protein-signaling modulator 3. (162 aa)
	NOTCH4	Neurogenic locus notch homolog protein 4. (1996 aa)
	DTX1	E3 ubiquitin-protein ligase DTX1. (398 aa)
	CREBBP	CREB-binding protein isoform X3. (2433 aa)
	ADAM17	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1. (822 aa)
	MINDY3	Ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X1. (445 aa)
	APH1B	Gamma-secretase subunit APH-1B isoform X1. (257 aa)
	HDAC2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	NCOA7	Nuclear receptor coactivator 7 isoform X2. (839 aa)
	DTX3L	E3 ubiquitin-protein ligase DTX3L. (744 aa)
	MUC4	Mucin-4. (1126 aa)
	HES1	Transcription factor HES-1. (280 aa)
	DVL2	Segment polarity protein dishevelled homolog DVL-2. (734 aa)
	CNPY3	Protein canopy homolog 3. (279 aa)
	TLE3	Transducin-like enhancer protein 3 isoform X1. (772 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1 isoform X1. (2567 aa)
	DVL3	Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa)
	MAML1	Mastermind-like protein 1. (957 aa)
	EYS	LOW QUALITY PROTEIN: protein eyes shut homolog. (595 aa)
	PTCRA	Pre T-cell antigen receptor alpha. (244 aa)
	TLE4	Transducin-like enhancer protein 4 isoform X1. (774 aa)
	OXR1	Oxidation resistance protein 1 isoform X4. (873 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2. (2471 aa)

Your Current Organism:

Neomonachus schauinslandi

NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM17	CTBP1	A0A2Y9HNK1	A0A2Y9G5G4	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	C-terminal-binding protein 1 isoform X1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.473
ADAM17	DLL1	A0A2Y9HNK1	A0A2Y9HB84	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
ADAM17	DLL3	A0A2Y9HNK1	A0A2Y9HYA6	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	LOW QUALITY PROTEIN: delta-like protein 3.	0.510
ADAM17	DVL3	A0A2Y9HNK1	A0A2Y9H954	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Segment polarity protein dishevelled homolog DVL-3 isoform X1.	0.473
ADAM17	EYS	A0A2Y9HNK1	A0A2Y9H820	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	LOW QUALITY PROTEIN: protein eyes shut homolog.	0.560
ADAM17	JAG1	A0A2Y9HNK1	A0A2Y9GZW5	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.497
ADAM17	NCSTN	A0A2Y9HNK1	A0A2Y9GJD6	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Nicastrin.	0.742
ADAM17	NOTCH1	A0A2Y9HNK1	A0A2Y9HAI0	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Neurogenic locus notch homolog protein 1 isoform X1.	0.886
ADAM17	NOTCH2	A0A2Y9HNK1	A0A2Y9H2L6	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Neurogenic locus notch homolog protein 2.	0.938
ADAM17	NOTCH3	A0A2Y9HNK1	A0A2Y9GIH9	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Neurogenic locus notch homolog protein 3 isoform X1.	0.942
ADAM17	NOTCH4	A0A2Y9HNK1	A0A2Y9HSE9	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Neurogenic locus notch homolog protein 4.	0.861
ADAM17	NUMB	A0A2Y9HNK1	A0A2Y9G8V6	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Protein numb homolog isoform X1.	0.501
ADAM17	PSEN1	A0A2Y9HNK1	A0A2Y9G8X7	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.546
ADAM17	PSEN2	A0A2Y9HNK1	A0A2Y9H1T4	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.490
ADAM17	PSENEN	A0A2Y9HNK1	A0A2Y9HYD4	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Gamma-secretase subunit PEN-2.	0.446
ADAM17	RBPJL	A0A2Y9HNK1	A0A2Y9GZE2	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Recombining binding protein suppressor of hairless-like protein.	0.481
AES	CREBBP	A0A2Y9GV64	A0A2Y9HQT7	Amino-terminal enhancer of split.	CREB-binding protein isoform X3.	0.484
AES	CTBP1	A0A2Y9GV64	A0A2Y9G5G4	Amino-terminal enhancer of split.	C-terminal-binding protein 1 isoform X1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.418
AES	CTBP2	A0A2Y9GV64	A0A2Y9IDM7	Amino-terminal enhancer of split.	C-terminal-binding protein 2 isoform X1.	0.418
AES	EP300	A0A2Y9GV64	A0A2Y9GZ72	Amino-terminal enhancer of split.	Histone acetyltransferase p300.	0.481