(55 nodes) Hedgehog signaling pathway network (Neomonachus schauinslandi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CSNK1G3	Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (424 aa)
	KIF3A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
	ATRNL1	Attractin-like protein 1. (1383 aa)
	SMO	Smoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	CSNK1A1	Casein kinase I isoform X4; Belongs to the protein kinase superfamily. (364 aa)
	GAS1	Growth arrest-specific protein 1. (350 aa)
	EVC	Ellis-van Creveld syndrome protein. (962 aa)
	PTCH1	Protein patched homolog 1. (1301 aa)
	HHIP	Hedgehog-interacting protein. (700 aa)
	CSNK1D	Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (428 aa)
	CUL3	Cullin-3 isoform X1; Belongs to the cullin family. (768 aa)
	PTCH2	LOW QUALITY PROTEIN: protein patched homolog 2. (1207 aa)
	GPR161	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (530 aa)
	GRK2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
	BCL2	Apoptosis regulator Bcl-2 isoform X1. (234 aa)
	LRP4	LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 4. (2035 aa)
	CUNH16orf52	Uncharacterized protein C16orf52 homolog. (167 aa)
	SMURF1	E3 ubiquitin-protein ligase. (731 aa)
	GLI1	LOW QUALITY PROTEIN: zinc finger protein GLI1. (1105 aa)
	LOC110577932	Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (431 aa)
	CCND1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	CCND2	G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
	SHH	Sonic hedgehog protein. (394 aa)
	ATRN	Attractin. (1421 aa)
	GSK3B	Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	LMBR1	Limb region 1 protein homolog; Belongs to the LIMR family. (490 aa)
	CUL1	Cullin-1 isoform X1; Belongs to the cullin family. (801 aa)
	BOC	Brother of CDO. (1110 aa)
	GLI2	Zinc finger protein GLI2. (1415 aa)
	CSNK1G1	Casein kinase I; Belongs to the protein kinase superfamily. (459 aa)
	CDON	Cell adhesion molecule-related/down-regulated by oncogenes. (1260 aa)
	MEGF8	LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 8. (2789 aa)
	ARRB2	Beta-arrestin-2. (409 aa)
	ARR3	arrestin-C. (392 aa)
	SMURF2	E3 ubiquitin-protein ligase. (736 aa)
	KIF27	Kinesin-like protein KIF27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1401 aa)
	EVC2	Limbin. (1299 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
	BTRC	LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 1A. (605 aa)
	TSPAN33	Tetraspanin. (283 aa)
	MGRN1	E3 ubiquitin-protein ligase MGRN1 isoform X1. (577 aa)
	SPOPL	Speckle-type POZ protein-like. (392 aa)
	KIF7	Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1301 aa)
	DHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	CSNK1G2	Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (442 aa)
	LRP2	LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 2. (4645 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	LMBR1L	Protein LMBR1L; Belongs to the LIMR family. (489 aa)
	ARRB1	Beta-arrestin-1. (418 aa)
	SPOP	Speckle-type POZ protein. (374 aa)
	GLI3	Transcriptional activator GLI3. (1589 aa)
	GRK3	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (665 aa)
	FBXW11	F-box/WD repeat-containing protein 11. (515 aa)

Your Current Organism:

Neomonachus schauinslandi

NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARR3	GLI1	A0A2Y9GAG7	A0A2Y9GUK1	arrestin-C.	LOW QUALITY PROTEIN: zinc finger protein GLI1.	0.791
ARR3	GLI2	A0A2Y9GAG7	A0A2Y9HIP8	arrestin-C.	Zinc finger protein GLI2.	0.785
ARR3	GLI3	A0A2Y9GAG7	A0A2Y9I5S5	arrestin-C.	Transcriptional activator GLI3.	0.783
ARR3	GPR161	A0A2Y9GAG7	A0A2Y9GLS9	arrestin-C.	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.815
ARR3	GRK2	A0A2Y9GAG7	A0A2Y9GNH4	arrestin-C.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.886
ARR3	GRK3	A0A2Y9GAG7	A0A2Y9I5I8	arrestin-C.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.857
ARR3	KIF3A	A0A2Y9GAG7	A0A2Y9I0Y7	arrestin-C.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.860
ARR3	SMO	A0A2Y9GAG7	A0A2Y9HYQ2	arrestin-C.	Smoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.852
ARRB1	GLI1	A0A2Y9I8Q5	A0A2Y9GUK1	Beta-arrestin-1.	LOW QUALITY PROTEIN: zinc finger protein GLI1.	0.802
ARRB1	GLI2	A0A2Y9I8Q5	A0A2Y9HIP8	Beta-arrestin-1.	Zinc finger protein GLI2.	0.797
ARRB1	GLI3	A0A2Y9I8Q5	A0A2Y9I5S5	Beta-arrestin-1.	Transcriptional activator GLI3.	0.794
ARRB1	GPR161	A0A2Y9I8Q5	A0A2Y9GLS9	Beta-arrestin-1.	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.824
ARRB1	GRK2	A0A2Y9I8Q5	A0A2Y9GNH4	Beta-arrestin-1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.891
ARRB1	GRK3	A0A2Y9I8Q5	A0A2Y9I5I8	Beta-arrestin-1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.864
ARRB1	KIF3A	A0A2Y9I8Q5	A0A2Y9I0Y7	Beta-arrestin-1.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.867
ARRB1	SMO	A0A2Y9I8Q5	A0A2Y9HYQ2	Beta-arrestin-1.	Smoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.860
ARRB2	GLI1	A0A2Y9HL08	A0A2Y9GUK1	Beta-arrestin-2.	LOW QUALITY PROTEIN: zinc finger protein GLI1.	0.802
ARRB2	GLI2	A0A2Y9HL08	A0A2Y9HIP8	Beta-arrestin-2.	Zinc finger protein GLI2.	0.797
ARRB2	GLI3	A0A2Y9HL08	A0A2Y9I5S5	Beta-arrestin-2.	Transcriptional activator GLI3.	0.794
ARRB2	GPR161	A0A2Y9HL08	A0A2Y9GLS9	Beta-arrestin-2.	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.824