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E2F4 E2F4 LOC110583310 LOC110583310 THBS1 THBS1 CHRD CHRD PPP2CB PPP2CB TGFBR1 TGFBR1 THSD4 THSD4 NEO1 NEO1 CUL1 CUL1 TGIF2LX TGIF2LX BMP5 BMP5 TGIF2 TGIF2 MATN4 MATN4 GDF6 GDF6 E2F5 E2F5 MATN2 MATN2 RBX1 RBX1 MAPK1 MAPK1 INHBE INHBE GDF5 GDF5 ID1 ID1 BMP2 BMP2 RBL1 RBL1 EP300 EP300 DCN DCN SP1 SP1 INTS8 INTS8 BAMBI BAMBI MYC MYC HFE2 HFE2 ADAMTSL4 ADAMTSL4 SMAD7 SMAD7 SMAD2 SMAD2 TGIF1 TGIF1 INHBC INHBC LTBP3 LTBP3 AMHR2 AMHR2 FMOD FMOD SMAD4 SMAD4 ROCK1 ROCK1 RPS6KB2 RPS6KB2 PITX2 PITX2 LOC110575420 LOC110575420 ZFYVE9 ZFYVE9 GREM2 GREM2 ID3 ID3 LOC110574723 LOC110574723 SNAPIN SNAPIN LOC110572649 LOC110572649 RGMA RGMA PPP2R1A PPP2R1A BMPR1B BMPR1B LTBP2 LTBP2 LOC110571365 LOC110571365 SMURF1 SMURF1 TGFBR2 TGFBR2 TGFB3 TGFB3 SMAD9 SMAD9 LOC110571363 LOC110571363 SMAD1 SMAD1 PKNOX1 PKNOX1 BMP7 BMP7 IFNG IFNG SMURF2 SMURF2 GREM1 GREM1 SMAD3 SMAD3 FBN1 FBN1 SMAD6 SMAD6 PPP2R1B PPP2R1B PKNOX2 PKNOX2 TNF TNF BMP6 BMP6 ID2 ID2 LDAH LDAH LTBP1 LTBP1 INHBB INHBB TFDP1 TFDP1 CREBBP CREBBP ID4 ID4 FST FST ZFYVE16 ZFYVE16 RGMB RGMB GDF7 GDF7 BMPR1A BMPR1A NODAL NODAL TGFB2 TGFB2 MAPK3 MAPK3 TGFB1 TGFB1 LTBP4 LTBP4 USF2 USF2 PITX3 PITX3 FBN2 FBN2 SMAD5 SMAD5 PITX1 PITX1 SKP1 SKP1 HAMP HAMP BMPR2 BMPR2 BMP4 BMP4 INHBA INHBA ACVR1 ACVR1 ACVR2A ACVR2A PPP2CA PPP2CA ACVR1B ACVR1B AMH AMH FSTL3 FSTL3 FBN3 FBN3 RPS6KB1 RPS6KB1 ACVR1C ACVR1C NOG NOG ACVR2B ACVR2B ANKFN1 ANKFN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
E2F4Transcription factor E2F4 isoform X1. (399 aa)
LOC110583310Mothers against decapentaplegic homolog. (451 aa)
THBS1Thrombospondin-1. (1170 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (939 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
THSD4Thrombospondin type-1 domain-containing protein 4. (658 aa)
NEO1Neogenin. (1417 aa)
CUL1Cullin-1 isoform X1; Belongs to the cullin family. (801 aa)
TGIF2LXHomeobox protein TGIF2LX. (215 aa)
BMP5Bone morphogenetic protein 5 isoform X1. (472 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
MATN4Matrilin-4. (624 aa)
GDF6Growth/differentiation factor 6. (463 aa)
E2F5Transcription factor E2F5 isoform X1. (346 aa)
MATN2Matrilin-2 isoform X1. (957 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
INHBEInhibin beta E chain. (351 aa)
GDF5Growth/differentiation factor 5. (499 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
EP300Histone acetyltransferase p300. (2420 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
SP1Transcription factor Sp1. (786 aa)
INTS8Integrator complex subunit 8. (994 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
HFE2Hemojuvelin. (428 aa)
ADAMTSL4ADAMTS-like protein 4 isoform X1. (1070 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGIF1Homeobox protein TGIF1. (272 aa)
INHBCInhibin beta C chain. (352 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1298 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (544 aa)
FMODFibromodulin. (376 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
PITX2Homeobox protein. (325 aa)
LOC110575420Bone morphogenetic protein 8B. (352 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1423 aa)
GREM2Gremlin. (168 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
LOC110574723Neuroblastoma suppressor of tumorigenicity 1. (175 aa)
SNAPINSNARE-associated protein Snapin. (137 aa)
LOC110572649Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
RGMARepulsive guidance molecule A isoform X1. (459 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (589 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LTBP2Latent-transforming growth factor beta-binding protein 2 isoform X1. (1827 aa)
LOC110571365Left-right determination factor. (364 aa)
SMURF1E3 ubiquitin-protein ligase. (731 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
LOC110571363Left-right determination factor. (364 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PKNOX1Homeobox protein PKNOX1. (436 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
SMURF2E3 ubiquitin-protein ligase. (736 aa)
GREM1Gremlin. (184 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
FBN1Fibrillin-1. (2868 aa)
SMAD6Mothers against decapentaplegic homolog. (498 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (693 aa)
PKNOX2Homeobox protein PKNOX2. (472 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
BMP6Bone morphogenetic protein 6. (490 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
LDAHLipid droplet-associated hydrolase. (325 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1. (1393 aa)
INHBBInhibin beta B chain. (407 aa)
TFDP1Transcription factor. (410 aa)
CREBBPCREB-binding protein isoform X3. (2433 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
FSTFollistatin isoform X1. (344 aa)
ZFYVE16Zinc finger FYVE domain-containing protein 16. (1540 aa)
RGMBRGM domain family member B. (749 aa)
GDF7Growth/differentiation factor 7. (403 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NODALNodal homolog. (348 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4. (1602 aa)
USF2Upstream stimulatory factor 2. (261 aa)
PITX3Homeobox protein. (302 aa)
FBN2Fibrillin-2. (2910 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PITX1Homeobox protein. (313 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
HAMPHepcidin. (83 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (944 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (456 aa)
INHBAInhibin beta A chain. (424 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (405 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
AMHMuellerian-inhibiting factor. (581 aa)
FSTL3Follistatin-related protein 3. (262 aa)
FBN3Fibrillin-3. (2352 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (443 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
ANKFN1Ankyrin repeat and fibronectin type-III domain-containing protein 1. (755 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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