STRINGSTRING
ERAS ERAS HDAC4 HDAC4 EFCAB13 EFCAB13 MYL4 MYL4 UCP1 UCP1 MRAS MRAS CALM1 CALM1 GNB2 GNB2 PIK3R4 PIK3R4 SLC8A3 SLC8A3 PLIN1 PLIN1 PPARGC1A PPARGC1A LOC110572425 LOC110572425 GNG8 GNG8 AKT1 AKT1 RRAS RRAS SPHK2 SPHK2 GNG12 GNG12 PLAT PLAT MEF2A MEF2A BECN1 BECN1 SNAPIN SNAPIN SLC8A2 SLC8A2 SPHK1 SPHK1 RPS6 RPS6 ADCY10 ADCY10 AKT3 AKT3 BECN2 BECN2 PIK3CG PIK3CG KLF2 KLF2 NOTCH3 NOTCH3 HDAC5 HDAC5 MEF2D MEF2D PRKAA2 PRKAA2 SLC9A1 SLC9A1 CALML6 CALML6 ITPR3 ITPR3 APLNR APLNR MEF2B MEF2B SMAD2 SMAD2 RRAS2 RRAS2 PRKAB2 PRKAB2 PLCB4 PLCB4 JAG1 JAG1 MAPK1 MAPK1 GNAI1 GNAI1 CSDE1 CSDE1 GNAI3 GNAI3 KRAS KRAS GEM GEM ITPR2 ITPR2 GNB3 GNB3 MYLK2 MYLK2 ADCY8 ADCY8 PLCB1 PLCB1 PLIN3 PLIN3 LOC110593709 LOC110593709 GNG14 GNG14 MYLK3 MYLK3 CDH1 CDH1 UCP3 UCP3 GNG7 GNG7 PRKAG1 PRKAG1 GABARAPL2 GABARAPL2 NOS2 NOS2 PRKACA PRKACA RPS6KB1 RPS6KB1 PRKAG3 PRKAG3 ADCY1 ADCY1 ADCY6 ADCY6 PRKAB1 PRKAB1 MAP2K2 MAP2K2 ADCY7 ADCY7 LOC110592076 LOC110592076 UCP2 UCP2 GNGT2 GNGT2 RRAD RRAD EGR1 EGR1 LOC110592210 LOC110592210 AKT2 AKT2 LOC110592156 LOC110592156 ADCY2 ADCY2 SPP1 SPP1 TFAM TFAM GNG2 GNG2 CAMK4 CAMK4 PRKCE PRKCE RYR1 RYR1 MAPK3 MAPK3 MYL2 MYL2 NOS1 NOS1 ADCY9 ADCY9 PTRHD1 PTRHD1 MYLK4 MYLK4 MEF2C MEF2C NRF1 NRF1 LIPE LIPE FBXO21 FBXO21 GNG10 GNG10 GNG11 GNG11 REM1 REM1 NRAS NRAS GNGT1 GNGT1 LOC110581982 LOC110581982 LOC110581981 LOC110581981 LOC110581983 LOC110581983 LOC110582045 LOC110582045 GNG5 GNG5 HRAS HRAS LOC110582265 LOC110582265 GNB4 GNB4 ADCY5 ADCY5 PRKACB PRKACB PRKAG2 PRKAG2 NOS3 NOS3 CTGF CTGF GABARAPL1 GABARAPL1 TGFBR1 TGFBR1 MAP2K1 MAP2K1 GNB5 GNB5 LOC110584545 LOC110584545 SERPINE1 SERPINE1 GABARAP GABARAP MFSD6L MFSD6L ITPR1 ITPR1 RAF1 RAF1 PLCB2 PLCB2 LOC110583310 LOC110583310 ADCY4 ADCY4 SMAD3 SMAD3 CALML4 CALML4 GNG4 GNG4 RYR2 RYR2 PRKAA1 PRKAA1 TMEM145 TMEM145 CALML5 CALML5 LOC110586587 LOC110586587 PIK3R5 PIK3R5 PIK3R6 PIK3R6 ADCY3 ADCY3 RYR3 RYR3 SLC8A1 SLC8A1 GNG13 GNG13 PLCB3 PLCB3 RPS6KB2 RPS6KB2 GNB1 GNB1 MTOR MTOR PDE3B PDE3B APLN APLN AGTR1 AGTR1 PIK3C3 PIK3C3 SMAD4 SMAD4 GNAI2 GNAI2 GNG3 GNG3 MYL3 MYL3 CCND1 CCND1 GNA13 GNA13 EFCAB3 EFCAB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERASGTPase ERas. (233 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1028 aa)
EFCAB13LOW QUALITY PROTEIN: EF-hand calcium-binding domain-containing protein 13. (906 aa)
MYL4Myosin light chain 4. (191 aa)
UCP1Mitochondrial brown fat uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
MRASRas-related protein M-Ras. (132 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
PLIN1Perilipin; Belongs to the perilipin family. (477 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
LOC110572425Parvalbumin beta-like. (129 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RRASRas-related protein R-Ras isoform X1. (218 aa)
SPHK2Sphingosine kinase 2. (656 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
MEF2ALOW QUALITY PROTEIN: myocyte-specific enhancer factor 2A. (486 aa)
BECN1Beclin-1 isoform X1. (448 aa)
SNAPINSNARE-associated protein Snapin. (137 aa)
SLC8A2Sodium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
SPHK1Sphingosine kinase 1 isoform X1. (487 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ADCY10Adenylate cyclase type 10 isoform X1. (1610 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BECN2Beclin-2. (432 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa)
KLF2Krueppel-like factor 2. (357 aa)
NOTCH3Neurogenic locus notch homolog protein 3 isoform X1. (2322 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1134 aa)
MEF2DMyocyte-specific enhancer factor 2D isoform X1. (515 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
CALML6Calmodulin-like protein 6. (232 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2584 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
MEF2BMyocyte-specific enhancer factor 2B. (368 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RRAS2Ras-related protein R-Ras2. (127 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
KRASGTPase KRas. (188 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (597 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLIN3Perilipin; Belongs to the perilipin family. (496 aa)
LOC110593709LOW QUALITY PROTEIN: cadherin-1-like. (506 aa)
GNG14LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog. (100 aa)
MYLK3Myosin light chain kinase 3. (807 aa)
CDH1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
UCP3Mitochondrial uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (485 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
LOC110592076Calmodulin-like; Belongs to the calmodulin family. (210 aa)
UCP2Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (118 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
LOC110592210Calmodulin-like; Belongs to the calmodulin family. (149 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC110592156Calmodulin-like; Belongs to the calmodulin family. (98 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
SPP1Osteopontin. (272 aa)
TFAMTranscription factor A, mitochondrial isoform X1. (246 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (470 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
RYR1Ryanodine receptor 1. (4995 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1. (166 aa)
NOS1Nitric oxide synthase, brain isoform X1. (1467 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (389 aa)
MEF2CMyocyte-specific enhancer factor 2C. (463 aa)
NRF1LOW QUALITY PROTEIN: nuclear respiratory factor 1. (503 aa)
LIPEHormone-sensitive lipase isoform X1. (806 aa)
FBXO21F-box only protein 21 isoform X1. (627 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
NRASGTPase NRas. (189 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
LOC110581982Adenylate cyclase type 10-like. (313 aa)
LOC110581981Adenylate cyclase type 10-like. (131 aa)
LOC110581983Adenylate cyclase type 10-like. (162 aa)
LOC110582045Uncharacterized protein LOC110582045. (205 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC11058226540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (568 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
CTGFConnective tissue growth factor. (351 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (133 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
LOC110584545Histone deacetylase 5-like. (117 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
MFSD6LMajor facilitator superfamily domain-containing protein 6-like. (593 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
LOC110583310Mothers against decapentaplegic homolog. (451 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RYR2Ryanodine receptor 2. (5000 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
TMEM145Transmembrane protein 145. (508 aa)
CALML5Calmodulin-like protein 5. (149 aa)
LOC110586587Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (1008 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
RYR3Ryanodine receptor 3. (4777 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (965 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
PDE3BPhosphodiesterase. (1167 aa)
APLNApelin. (77 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MYL3Myosin light chain 3. (200 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
EFCAB3EF-hand calcium-binding domain-containing protein 3 isoform X1. (646 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (18%) [HD]