STRINGSTRING
PARD6G PARD6G LOC110593709 LOC110593709 WNT1 WNT1 CDH1 CDH1 YWHAE YWHAE WNT11 WNT11 FZD5 FZD5 NKD1 NKD1 FZD7 FZD7 APC2 APC2 AMH AMH NF2 NF2 WNT10B WNT10B RASSF6 RASSF6 PPP2CA PPP2CA ACTBL2 ACTBL2 PRKCI PRKCI AREG AREG LOC110591371 LOC110591371 PARD6A PARD6A BMP4 BMP4 YWHAH YWHAH TCF7 TCF7 WNT6 WNT6 APC APC SAV1 SAV1 BMPR2 BMPR2 FBXW11 FBXW11 WNT10A WNT10A AFP AFP MOB1B MOB1B WNT8B WNT8B PPP2R2B PPP2R2B YWHAG YWHAG WNT8A WNT8A FGF1 FGF1 CTNNA1 CTNNA1 DLG5 DLG5 WNT2 WNT2 MOB1A MOB1A FRMD6 FRMD6 WWC1 WWC1 WTIP WTIP TGFB1 TGFB1 AXIN1 AXIN1 PPP1CC PPP1CC FZD10 FZD10 FZD9 FZD9 TGFB2 TGFB2 CTNNA3 CTNNA3 BMPR1A BMPR1A GDF7 GDF7 TCF7L2 TCF7L2 BTRC BTRC TCF7L1 TCF7L1 WNT16 WNT16 CTNNA2 CTNNA2 FZD3 FZD3 YAP1 YAP1 PPP2R2A PPP2R2A BIRC2 BIRC2 PPP1CB PPP1CB YWHAQ YWHAQ AJUBA AJUBA LDAH LDAH BMP6 BMP6 WNT9A WNT9A BIRC3 BIRC3 PPP2R1B PPP2R1B SOX1 SOX1 GLI2 GLI2 SMAD3 SMAD3 LOC110583310 LOC110583310 LATS1 LATS1 WNT7A WNT7A WNT5A WNT5A SERPINE1 SERPINE1 DLG1 DLG1 SOX2 SOX2 MYO15A MYO15A DLG4 DLG4 LLGL1 LLGL1 DVL2 DVL2 PPP2CB PPP2CB TGFBR1 TGFBR1 CCND3 CCND3 LRRC1 LRRC1 CTGF CTGF SRY SRY GSK3B GSK3B DVL3 DVL3 BMP5 BMP5 WNT2B WNT2B CRB2 CRB2 SCRIB SCRIB GDF6 GDF6 TEAD4 TEAD4 WNT5B WNT5B CCND2 CCND2 FZD6 FZD6 SNAI2 SNAI2 FZD1 FZD1 GDF5 GDF5 ID1 ID1 BMP2 BMP2 YWHAB YWHAB YWHAZ YWHAZ STK3 STK3 RASSF1 RASSF1 MYC MYC LOC110578691 LOC110578691 LOC110578430 LOC110578430 FZD8 FZD8 WWTR1 WWTR1 SMAD7 SMAD7 SMAD2 SMAD2 WNT7B WNT7B CCND1 CCND1 LOC110577932 LOC110577932 PARD3 PARD3 NKD2 NKD2 TEAD3 TEAD3 DLG2 DLG2 FZD4 FZD4 AMOT AMOT SMAD4 SMAD4 PARD6B PARD6B LEF1 LEF1 WNT4 WNT4 TEAD1 TEAD1 PPP1CA PPP1CA LIMD1 LIMD1 ACTL8 ACTL8 PRKCZ PRKCZ SOX3 SOX3 LOC110575420 LOC110575420 DVL1 DVL1 CRB1 CRB1 TP73 TP73 ACTG1 ACTG1 MYO15B MYO15B FZD2 FZD2 ACTB ACTB PPP2R1A PPP2R1A BMPR1B BMPR1B DLG3 DLG3 TEAD2 TEAD2 BBC3 BBC3 LLGL2 LLGL2 CSNK1D CSNK1D BIRC5 BIRC5 TP53BP2 TP53BP2 TGFBR2 TGFBR2 PATJ PATJ MPP5 MPP5 TGFB3 TGFB3 SMAD1 SMAD1 AXIN2 AXIN2 WNT3 WNT3 ITGB2 ITGB2 BMP7 BMP7 PPP2R2C PPP2R2C WNT9B WNT9B CTNNB1 CTNNB1 LATS2 LATS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARD6GPartitioning defective 6 homolog gamma. (363 aa)
LOC110593709LOW QUALITY PROTEIN: cadherin-1-like. (506 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CDH1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
NKD1Protein naked cuticle homolog 1. (470 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
APC2Adenomatous polyposis coli protein 2 isoform X1. (2265 aa)
AMHMuellerian-inhibiting factor. (581 aa)
NF2Merlin isoform X1. (596 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
RASSF6Ras association domain-containing protein 6. (384 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ACTBL2Beta-actin-like protein 2 isoform X1. (376 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
AREGAmphiregulin. (253 aa)
LOC110591371Alpha-fetoprotein-like. (652 aa)
PARD6APartitioning defective 6 homolog alpha isoform X1. (346 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (456 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
TCF7Transcription factor 7. (419 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
APCAdenomatous polyposis coli protein. (2844 aa)
SAV1Protein salvador homolog 1. (384 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (944 aa)
FBXW11F-box/WD repeat-containing protein 11. (515 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (452 aa)
AFPAlpha-fetoprotein. (626 aa)
MOB1BMOB kinase activator 1B. (216 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CTNNA1Catenin alpha-1. (906 aa)
DLG5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1942 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
MOB1AMOB kinase activator 1A isoform X1. (223 aa)
FRMD6FERM domain-containing protein 6 isoform X1. (622 aa)
WWC1Protein KIBRA isoform X1. (1117 aa)
WTIPWilms tumor protein 1-interacting protein. (477 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
AXIN1Axin-1 isoform X1. (867 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
CTNNA3Catenin alpha-3. (895 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GDF7Growth/differentiation factor 7. (403 aa)
TCF7L2Transcription factor 7-like 2. (446 aa)
BTRCLOW QUALITY PROTEIN: F-box/WD repeat-containing protein 1A. (605 aa)
TCF7L1Transcription factor 7-like 1. (463 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
CTNNA2Catenin alpha-2 isoform X1. (969 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
YAP1Transcriptional coactivator YAP1. (437 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (619 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
AJUBALIM domain-containing protein ajuba. (548 aa)
LDAHLipid droplet-associated hydrolase. (325 aa)
BMP6Bone morphogenetic protein 6. (490 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (346 aa)
BIRC3Baculoviral IAP repeat-containing protein 3 isoform X1. (604 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (693 aa)
SOX1Transcription factor SOX-1. (258 aa)
GLI2Zinc finger protein GLI2. (1415 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC110583310Mothers against decapentaplegic homolog. (451 aa)
LATS1Serine/threonine-protein kinase LATS1. (1132 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
SOX2LOW QUALITY PROTEIN: transcription factor SOX-2. (322 aa)
MYO15ALOW QUALITY PROTEIN: unconventional myosin-XV; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3394 aa)
DLG4Disks large homolog 4 isoform X2; Belongs to the MAGUK family. (766 aa)
LLGL1Lethal(2) giant larvae protein homolog 1. (1067 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CCND3G1/S-specific cyclin-D3; Belongs to the cyclin family. (291 aa)
LRRC1Leucine-rich repeat-containing protein 1 isoform X1. (524 aa)
CTGFConnective tissue growth factor. (351 aa)
SRYSex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development; Belongs to the SRY family. (221 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa)
BMP5Bone morphogenetic protein 5 isoform X1. (472 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
CRB2Protein crumbs homolog 2. (1110 aa)
SCRIBProtein scribble homolog. (1674 aa)
GDF6Growth/differentiation factor 6. (463 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (461 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (648 aa)
GDF5Growth/differentiation factor 5. (499 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (244 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
STK3Serine/threonine-protein kinase 3. (491 aa)
RASSF1Ras association domain-containing protein 1 isoform X1. (340 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
LOC110578691Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (338 aa)
LOC110578430Integrin beta. (250 aa)
FZD8Frizzled-8. (243 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LOC110577932Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (431 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1359 aa)
NKD2Protein naked cuticle homolog 2. (473 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (398 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
AMOTAngiomotin. (1067 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PARD6BPartitioning defective 6 homolog beta. (370 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (424 aa)
TEAD1Transcriptional enhancer factor TEF-1 isoform X1. (432 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LIMD1LIM domain-containing protein 1. (671 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
SOX3Transcription factor SOX-3 isoform X1. (445 aa)
LOC110575420Bone morphogenetic protein 8B. (352 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
CRB1Protein crumbs homolog 1 isoform X1. (1337 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (617 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
MYO15BLOW QUALITY PROTEIN: myosin XVB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2946 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
ACTBActin, cytoplasmic 1. (375 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (589 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DLG3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (724 aa)
TEAD2Transcriptional enhancer factor TEF-4 isoform X1. (451 aa)
BBC3Bcl-2-binding component 3. (193 aa)
LLGL2Lethal(2) giant larvae protein homolog 2. (1020 aa)
CSNK1DCasein kinase I isoform X1; Belongs to the protein kinase superfamily. (428 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
TP53BP2Apoptosis-stimulating of p53 protein 2 isoform X1. (1154 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PATJinaD-like protein. (1907 aa)
MPP5MAGUK p55 subfamily member 5; Belongs to the MAGUK family. (675 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
AXIN2Axin-2 isoform X1. (840 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
ITGB2Integrin beta. (453 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (477 aa)
CTNNB1Catenin beta-1. (781 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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