STRINGSTRING
TCF3 TCF3 WNT1 WNT1 ONECUT3 ONECUT3 TBX2 TBX2 WNT11 WNT11 LIF LIF ACVR2B ACVR2B ZFHX3 ZFHX3 FZD5 FZD5 ACVR1C ACVR1C FZD7 FZD7 APC2 APC2 MAP2K2 MAP2K2 WNT10B WNT10B ACVR1B ACVR1B LHX1 LHX1 ACVR1 ACVR1 HOXB1 HOXB1 PCGF2 PCGF2 FGFR2 FGFR2 INHBA INHBA BMP4 BMP4 TCF7 TCF7 IL6ST IL6ST RIF1 RIF1 AKT2 AKT2 HOXD1 HOXD1 WNT6 WNT6 APC APC BMPR2 BMPR2 WNT10A WNT10A SKIL SKIL PCGF5 PCGF5 WNT8B WNT8B WNT8A WNT8A PIK3R1 PIK3R1 NEUROG1 NEUROG1 SMAD5 SMAD5 POU5F2 POU5F2 WNT2 WNT2 REST REST OTX1 OTX1 MEIS1 MEIS1 MAPK3 MAPK3 AXIN1 AXIN1 FZD10 FZD10 FZD9 FZD9 NODAL NODAL BMPR1A BMPR1A HAND1 HAND1 PCGF6 PCGF6 WNT16 WNT16 PCGF1 PCGF1 FZD3 FZD3 FGFR4 FGFR4 ID4 ID4 LHX5 LHX5 BMI1 BMI1 ISL1 ISL1 ESRRG ESRRG TBX3 TBX3 MEIS2 MEIS2 INHBB INHBB ID2 ID2 HESX1 HESX1 JARID2 JARID2 POU5F1 POU5F1 WNT9A WNT9A NFIL3 NFIL3 LIFR LIFR SOX1 SOX1 ZIC2 ZIC2 SMAD3 SMAD3 LOC110583604 LOC110583604 LOC110583310 LOC110583310 RAF1 RAF1 WNT7A WNT7A WNT5A WNT5A SOX2 SOX2 DVL2 DVL2 JAK2 JAK2 ONECUT1 ONECUT1 MAP2K1 MAP2K1 ISL2 ISL2 SRY SRY NANOG NANOG GSK3B GSK3B DVL3 DVL3 PIK3CA PIK3CA HRAS HRAS WNT2B WNT2B NRAS NRAS WNT5B WNT5B KRAS KRAS CSDE1 CSDE1 MYF5 MYF5 FZD6 FZD6 DUSP9 DUSP9 DLX5 DLX5 IGF1 IGF1 FZD1 FZD1 HOXA1 HOXA1 MAPK1 MAPK1 INHBE INHBE MAPK11 MAPK11 ID1 ID1 MYC MYC ONECUT2 ONECUT2 LOC110578691 LOC110578691 SETDB1 SETDB1 FZD8 FZD8 MAPK12 MAPK12 SMAD2 SMAD2 WNT7B WNT7B INHBC INHBC FZD4 FZD4 SMAD4 SMAD4 PAX6 PAX6 ZIC1 ZIC1 PIK3CD PIK3CD WNT4 WNT4 PIK3R3 PIK3R3 JAK3 JAK3 MAPK14 MAPK14 ZIC3 ZIC3 MAPK13 MAPK13 SOX3 SOX3 DVL1 DVL1 ID3 ID3 STAT3 STAT3 PIK3R2 PIK3R2 AKT3 AKT3 PRRX1 PRRX1 FGF2 FGF2 GRB2 GRB2 SMARCAD1 SMARCAD1 FZD2 FZD2 FGFR1 FGFR1 KAT6A KAT6A BMPR1B BMPR1B JAK1 JAK1 AKT1 AKT1 IGF1R IGF1R LOC110571365 LOC110571365 PIK3CB PIK3CB ESRRB ESRRB SMAD9 SMAD9 LOC110571363 LOC110571363 SMAD1 SMAD1 AXIN2 AXIN2 WNT3 WNT3 ERAS ERAS FGFR3 FGFR3 WNT9B WNT9B ESX1 ESX1 CTNNB1 CTNNB1 PCGF3 PCGF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TCF3Transcription factor E2-alpha isoform X1. (653 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ONECUT3One cut domain family member. (301 aa)
TBX2T-box transcription factor TBX2. (713 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LIFLeukemia inhibitory factor. (202 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
ZFHX3Zinc finger homeobox protein 3. (3671 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (443 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
APC2Adenomatous polyposis coli protein 2 isoform X1. (2265 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
HOXB1Homeobox protein Hox-B1. (304 aa)
PCGF2Polycomb group RING finger protein 2 isoform X1. (419 aa)
FGFR2Fibroblast growth factor receptor. (842 aa)
INHBAInhibin beta A chain. (424 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (456 aa)
TCF7Transcription factor 7. (419 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (914 aa)
RIF1LOW QUALITY PROTEIN: telomere-associated protein RIF1. (2480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HOXD1Homeobox protein Hox-D1. (326 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
APCAdenomatous polyposis coli protein. (2844 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (944 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (452 aa)
SKILSki-like protein isoform X1. (684 aa)
PCGF5Polycomb group RING finger protein 5 isoform X1. (256 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
NEUROG1Neurogenin-1. (249 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
POU5F2POU domain protein. (339 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RESTRE1-silencing transcription factor. (1009 aa)
OTX1Homeobox protein OTX1. (354 aa)
MEIS1Homeobox protein Meis1 isoform X2. (474 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
AXIN1Axin-1 isoform X1. (867 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
NODALNodal homolog. (348 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
PCGF6Polycomb group RING finger protein 6 isoform X1. (349 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
PCGF1Polycomb group RING finger protein 1 isoform X1. (280 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
LHX5LIM/homeobox protein Lhx5. (402 aa)
BMI1Polycomb complex protein BMI-1 isoform X1. (326 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
ESRRGEstrogen-related receptor gamma isoform X1. (458 aa)
TBX3T-box transcription factor TBX3. (727 aa)
MEIS2Homeobox protein Meis2 isoform X1. (477 aa)
INHBBInhibin beta B chain. (407 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
HESX1Homeobox expressed in ES cells 1. (185 aa)
JARID2Protein Jumonji isoform X1. (1250 aa)
POU5F1POU domain protein. (360 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (346 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)
LIFRLeukemia inhibitory factor receptor. (1097 aa)
SOX1Transcription factor SOX-1. (258 aa)
ZIC2Zinc finger protein ZIC 2. (488 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC110583604LOW QUALITY PROTEIN: homeobox protein NANOG-like. (297 aa)
LOC110583310Mothers against decapentaplegic homolog. (451 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SOX2LOW QUALITY PROTEIN: transcription factor SOX-2. (322 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
ONECUT1One cut domain family member. (465 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ISL2Insulin gene enhancer protein ISL-2. (359 aa)
SRYSex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development; Belongs to the SRY family. (221 aa)
NANOGHomeobox protein NANOG isoform X1. (310 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X1. (189 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
NRASGTPase NRas. (189 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
KRASGTPase KRas. (188 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
DUSP9Dual specificity protein phosphatase 9. (222 aa)
DLX5Homeobox protein DLX-5. (289 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (648 aa)
HOXA1Homeobox protein Hox-A1. (332 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
INHBEInhibin beta E chain. (351 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
ONECUT2One cut domain family member. (504 aa)
LOC110578691Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (338 aa)
SETDB1Histone-lysine N-methyltransferase SETDB1. (1297 aa)
FZD8Frizzled-8. (243 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
INHBCInhibin beta C chain. (352 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PAX6Paired box protein Pax-6 isoform X1. (436 aa)
ZIC1Zinc finger protein ZIC 1. (447 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (424 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ZIC3Zinc finger protein ZIC 3 isoform X1. (466 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
SOX3Transcription factor SOX-3 isoform X1. (445 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform X1. (245 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (374 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SMARCAD1annotation not available (1028 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
FGFR1Fibroblast growth factor receptor. (735 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1974 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
JAK1Tyrosine-protein kinase. (1156 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LOC110571365Left-right determination factor. (364 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
ESRRBSteroid hormone receptor ERR2 isoform X2. (433 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
LOC110571363Left-right determination factor. (364 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
AXIN2Axin-2 isoform X1. (840 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
ERASGTPase ERas. (233 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (477 aa)
ESX1Homeobox protein ESX1. (263 aa)
CTNNB1Catenin beta-1. (781 aa)
PCGF3Polycomb group RING finger protein 3. (242 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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