STRINGSTRING
PIK3R1 PIK3R1 PRKCI PRKCI COL1A1 COL1A1 ACTBL2 ACTBL2 ADCY7 ADCY7 ADCY6 ADCY6 ADCY1 ADCY1 PRKACA PRKACA P2RX1 P2RX1 TBXA2R TBXA2R STIM1 STIM1 RAP1B RAP1B MYLK3 MYLK3 PLCG2 PLCG2 PTK6 PTK6 SRMS SRMS PIK3CB PIK3CB VASP VASP AKT1 AKT1 ARHGAP35 ARHGAP35 TLNRD1 TLNRD1 ACTB ACTB ITGA2B ITGA2B PTGIR PTGIR ACTG1 ACTG1 AKT3 AKT3 PLA2G4A PLA2G4A PIK3CG PIK3CG PIK3R2 PIK3R2 RDH13 RDH13 GP6 GP6 FCER1G FCER1G F2RL3 F2RL3 MAPK13 MAPK13 PRKCZ PRKCZ MAPK14 MAPK14 ITPR3 ITPR3 F2 F2 ACTL8 ACTL8 PLCB3 PLCB3 FERMT3 FERMT3 PPP1CA PPP1CA PIK3R3 PIK3R3 P2RY12 P2RY12 PIK3CD PIK3CD ITGB1 ITGB1 P2RY1 P2RY1 ROCK1 ROCK1 ZNF408 ZNF408 GNAI2 GNAI2 RASGRP2 RASGRP2 APBB1IP APBB1IP MAPK12 MAPK12 LYN LYN PLCB4 PLCB4 LOC110579416 LOC110579416 SRC SRC MAPK11 MAPK11 MAPK1 MAPK1 LOC110579802 LOC110579802 COL1A2 COL1A2 GNAI1 GNAI1 RAP1A RAP1A GNAI3 GNAI3 ITPR2 ITPR2 MYLK2 MYLK2 ADCY8 ADCY8 PTGS1 PTGS1 PLCB1 PLCB1 TLN1 TLN1 VWF VWF ARHGEF1 ARHGEF1 PIK3CA PIK3CA GP5 GP5 ADCY5 ADCY5 PRKACB PRKACB DGCR6L DGCR6L TBXAS1 TBXAS1 NOS3 NOS3 GP1BB GP1BB GP1BA GP1BA LRRC15 LRRC15 ITPR1 ITPR1 GP9 GP9 PLCB2 PLCB2 JMJD7 JMJD7 PLA2G4F PLA2G4F PLA2G4B PLA2G4B PLA2G4D PLA2G4D ADCY4 ADCY4 FYN FYN TLN2 TLN2 SYK SYK GUCY1A2 GUCY1A2 PIK3R5 PIK3R5 PIK3R6 PIK3R6 ADCY3 ADCY3 SNAP23 SNAP23 ROCK2 ROCK2 RASGRP1 RASGRP1 LOC110587587 LOC110587587 PPP1CB PPP1CB PLA2G4E PLA2G4E BTK BTK PRKG1 PRKG1 ARHGEF12 ARHGEF12 FGG FGG GUCY1A3 GUCY1A3 FGB FGB VAMP8 VAMP8 MYLK4 MYLK4 PTRHD1 PTRHD1 F2R F2R ADCY9 ADCY9 PPP1CC PPP1CC LCP2 LCP2 FGA FGA GUCY1B3 GUCY1B3 MAPK3 MAPK3 ITGA2 ITGA2 ORAI1 ORAI1 PRKG2 PRKG2 ADCY2 ADCY2 COL3A1 COL3A1 AKT2 AKT2 GNAS GNAS LOC110569839 LOC110569839 DHRSX DHRSX ITGB3 ITGB3 GNA13 GNA13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
COL1A1Collagen alpha-1(I) chain. (1460 aa)
ACTBL2Beta-actin-like protein 2 isoform X1. (376 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
STIM1Stromal interaction molecule 1. (685 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
MYLK3Myosin light chain kinase 3. (807 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1200 aa)
PTK6Tyrosine-protein kinase. (486 aa)
SRMSTyrosine-protein kinase. (493 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
TLNRD1Mesoderm development candidate 1. (362 aa)
ACTBActin, cytoplasmic 1. (375 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (668 aa)
PTGIRProstacyclin receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PLA2G4APhospholipase A2. (733 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
RDH13Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (334 aa)
GP6Platelet glycoprotein VI. (338 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
F2RL3Proteinase-activated receptor 4; Belongs to the G-protein coupled receptor 1 family. (390 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2584 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
FERMT3Fermitin family homolog 3. (663 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
P2RY12P2Y purinoceptor 12. (339 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
P2RY1P2Y purinoceptor 1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ZNF408Zinc finger protein 408. (716 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
RASGRP2RAS guanyl-releasing protein 2 isoform X1. (609 aa)
APBB1IPAmyloid beta A4 precursor protein-binding family B member 1-interacting protein. (663 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LYNTyrosine-protein kinase. (512 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
LOC110579416Integrin alpha-IIb-like. (222 aa)
SRCTyrosine-protein kinase. (536 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LOC110579802LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (646 aa)
COL1A2Collagen alpha-2(I) chain. (1365 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (597 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PTGS1Prostaglandin G/H synthase 1 isoform X1. (600 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
TLN1Talin-1. (2541 aa)
VWFVon Willebrand factor. (2741 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1 isoform X1. (974 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GP5Platelet glycoprotein V. (575 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
DGCR6LProtein DGCR6L. (198 aa)
TBXAS1thromboxane-A synthase; Belongs to the cytochrome P450 family. (534 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
GP1BBPlatelet glycoprotein Ib beta chain. (210 aa)
GP1BAPlatelet glycoprotein Ib alpha chain. (385 aa)
LRRC15Leucine-rich repeat-containing protein 15. (580 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
GP9LOW QUALITY PROTEIN: platelet glycoprotein IX. (177 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
JMJD7jmjC domain-containing protein 7. (316 aa)
PLA2G4FPhospholipase A2. (860 aa)
PLA2G4BPhospholipase A2. (782 aa)
PLA2G4DPhospholipase A2. (817 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
FYNTyrosine-protein kinase. (537 aa)
TLN2Talin-2. (2542 aa)
SYKTyrosine-protein kinase. (635 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (1008 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1391 aa)
RASGRP1RAS guanyl-releasing protein 1. (956 aa)
LOC110587587Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (336 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PLA2G4EPhospholipase A2. (841 aa)
BTKTyrosine-protein kinase. (659 aa)
PRKG1cGMP-dependent protein kinase. (726 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12 isoform X1. (1543 aa)
FGGFibrinogen gamma chain isoform X1. (445 aa)
GUCY1A3Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
FGBFibrinogen beta chain. (477 aa)
VAMP8Vesicle-associated membrane protein 8. (101 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (389 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
FGAFibrinogen alpha chain. (868 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (637 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1105 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
DHRSXDehydrogenase/reductase SDR family member on chromosome X. (253 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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