STRINGSTRING
PIK3CB PIK3CB EPOR EPOR STAM2 STAM2 PIAS4 PIAS4 LOC110592050 LOC110592050 STAT4 STAT4 CSF3 CSF3 LIF LIF IL27RA IL27RA TYK2 TYK2 LOC110591202 LOC110591202 IL12A IL12A SOCS7 SOCS7 EGFR EGFR OSM OSM IL6ST IL6ST PDGFRA PDGFRA AKT2 AKT2 LOC110592052 LOC110592052 STAT1 STAT1 LOC110591947 LOC110591947 LOC110590306 LOC110590306 CTF1 CTF1 PIK3R1 PIK3R1 LOC110589792 LOC110589792 IL13 IL13 IL9 IL9 CSF2 CSF2 IL5 IL5 IL4 IL4 SOCS4 SOCS4 SOS2 SOS2 SOCS5 SOCS5 FCGBP FCGBP IFNL1 IFNL1 OSMR OSMR GHR GHR IL9R IL9R IL21R IL21R IL4R IL4R IL12B IL12B IFNA5 IFNA5 LEP LEP SOS1 SOS1 LOC110587131 LOC110587131 IL2RA IL2RA IL15RA IL15RA STAM STAM PTPN11 PTPN11 CREBBP CREBBP SOCS1 SOCS1 IL7R IL7R IRF9 IRF9 LOC110587134 LOC110587134 IL5RA IL5RA IFNB1 IFNB1 PDGFRB PDGFRB PRL PRL LOC110584655 LOC110584655 IL10RA IL10RA LIFR LIFR PRLR PRLR PIAS1 PIAS1 TSLP TSLP IL20RA IL20RA IFNGR1 IFNGR1 RAF1 RAF1 JAK2 JAK2 CCND3 CCND3 IL22RA2 IL22RA2 CNTFR CNTFR IFNE IFNE THPO THPO PTPN6 PTPN6 PIK3CA PIK3CA BCL2L1 BCL2L1 LOC110579526 LOC110579526 CCND2 CCND2 IL7 IL7 PDGFB PDGFB SOCS2 SOCS2 IL6 IL6 LOC110579958 LOC110579958 IL11 IL11 EP300 EP300 STAT6 STAT6 MYC MYC PIAS3 PIAS3 MCL1 MCL1 CSF2RB CSF2RB IL2RB IL2RB CCND1 CCND1 LOC110577978 LOC110577978 STAT2 STAT2 IL23A IL23A CISH CISH IL13RA1 IL13RA1 IL13RA2 IL13RA2 BCL2 BCL2 PIAS2 PIAS2 SOCS6 SOCS6 PIK3CD PIK3CD MPL MPL IFNLR1 IFNLR1 PIK3R3 PIK3R3 CNTF CNTF MTOR MTOR JAK3 JAK3 CDKN1A CDKN1A PIM1 PIM1 EGF EGF LOC110575329 LOC110575329 IL20 IL20 IL22RA1 IL22RA1 IL24 IL24 CSF3R CSF3R STAT3 STAT3 PIK3R2 PIK3R2 IL12RB1 IL12RB1 IL21 IL21 PTPN2 PTPN2 LOC110573272 LOC110573272 AKT3 AKT3 IL2 IL2 IL10 IL10 IL19 IL19 IFNK IFNK GRB2 GRB2 IL6R IL6R LOC110573273 LOC110573273 GFAP GFAP JAK1 JAK1 AKT1 AKT1 IL23R IL23R SOCS3 SOCS3 IL2RG IL2RG PDGFA PDGFA EPO EPO ZAN ZAN IL12RB2 IL12RB2 LEPR LEPR IFNAR1 IFNAR1 IL10RB IL10RB CRLF2 CRLF2 IL3RA IL3RA IFNG IFNG IFNGR2 IFNGR2 IL20RB IL20RB IL17D IL17D IFNAR2 IFNAR2 IL15 IL15 IL22 IL22 LOC110570393 LOC110570393
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (509 aa)
STAM2Signal transducing adapter molecule 2. (525 aa)
PIAS4E3 SUMO-protein ligase PIAS4 isoform X1. (513 aa)
LOC110592050LOW QUALITY PROTEIN: aldehyde oxidase 2-like. (1275 aa)
STAT4Signal transducer and activator of transcription. (694 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
LIFLeukemia inhibitory factor. (202 aa)
IL27RALOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha. (655 aa)
TYK2Tyrosine-protein kinase. (1189 aa)
LOC110591202Interleukin-3-like. (143 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
SOCS7Suppressor of cytokine signaling 7. (507 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
OSMoncostatin-M. (214 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (914 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC110592052Aldehyde oxidase. (1338 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
LOC110591947LOW QUALITY PROTEIN: aldehyde oxidase 4-like. (1335 aa)
LOC110590306Interferon lambda-3-like. (192 aa)
CTF1Cardiotrophin-1 isoform X1. (201 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110589792Cardiotrophin-2. (203 aa)
IL13Interleukin-13. (133 aa)
IL9Interleukin-9. (148 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (132 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
FCGBPIgGFc-binding protein. (3005 aa)
IFNL1Interferon lambda-1 isoform X1. (189 aa)
OSMRoncostatin-M-specific receptor subunit beta isoform X1. (983 aa)
GHRGrowth hormone receptor. (638 aa)
IL9RInterleukin-9 receptor. (470 aa)
IL21RInterleukin-21 receptor. (542 aa)
IL4RInterleukin-4 receptor subunit alpha isoform X1. (797 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
IFNA5LOW QUALITY PROTEIN: interferon alpha-5. (187 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
LOC110587131Interferon alpha-16-like. (182 aa)
IL2RAInterleukin-2 receptor subunit alpha. (300 aa)
IL15RALOW QUALITY PROTEIN: interleukin-15 receptor subunit alpha. (263 aa)
STAMSignal transducing adapter molecule 1. (536 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
CREBBPCREB-binding protein isoform X3. (2433 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
IL7RInterleukin-7 receptor subunit alpha. (457 aa)
IRF9Interferon regulatory factor 9. (410 aa)
LOC110587134LOW QUALITY PROTEIN: interferon omega-1-like. (187 aa)
IL5RAInterleukin-5 receptor subunit alpha. (419 aa)
IFNB1Interferon beta. (182 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
PRLProlactin isoform X1. (230 aa)
LOC110584655Four and a half LIM domains protein 1-like. (152 aa)
IL10RAInterleukin-10 receptor subunit alpha. (575 aa)
LIFRLeukemia inhibitory factor receptor. (1097 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (624 aa)
PIAS1E3 SUMO-protein ligase PIAS1. (651 aa)
TSLPLOW QUALITY PROTEIN: thymic stromal lymphopoietin. (182 aa)
IL20RAInterleukin-20 receptor subunit alpha. (567 aa)
IFNGR1LOW QUALITY PROTEIN: interferon gamma receptor 1. (474 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
CCND3G1/S-specific cyclin-D3; Belongs to the cyclin family. (291 aa)
IL22RA2Interleukin-22 receptor subunit alpha-2. (231 aa)
CNTFRCiliary neurotrophic factor receptor subunit alpha. (371 aa)
IFNEInterferon epsilon. (208 aa)
THPOThrombopoietin. (325 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
LOC110579526Signal transducer and activator of transcription 5A-like. (153 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (159 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
IL6Interleukin-6 isoform X1. (212 aa)
LOC110579958Signal transducer and activator of transcription 5B-like. (204 aa)
IL11Interleukin-11. (199 aa)
EP300Histone acetyltransferase p300. (2420 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
PIAS3E3 SUMO-protein ligase PIAS3 isoform X1. (642 aa)
MCL1LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1. (347 aa)
CSF2RBCytokine receptor common subunit beta. (863 aa)
IL2RBInterleukin-2 receptor subunit beta. (555 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LOC110577978Four and a half LIM domains protein 1. (119 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
IL23AInterleukin-23 subunit alpha. (210 aa)
CISHCytokine-inducible SH2-containing protein. (257 aa)
IL13RA1Interleukin-13 receptor subunit alpha-1. (286 aa)
IL13RA2Interleukin-13 receptor subunit alpha-2. (386 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
PIAS2E3 SUMO-protein ligase PIAS2. (612 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MPLThrombopoietin receptor. (637 aa)
IFNLR1Interferon lambda receptor 1. (581 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
CNTFCiliary neurotrophic factor. (199 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (320 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
IL20Interleukin-20. (176 aa)
IL22RA1Interleukin-22 receptor subunit alpha-1. (580 aa)
IL24Interleukin-24. (185 aa)
CSF3RGranulocyte colony-stimulating factor receptor isoform X1. (851 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
IL12RB1Interleukin-12 receptor subunit beta-1. (720 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
LOC110573272Signal transducer and activator of transcription 5A. (478 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
IL10Interleukin-10. (178 aa)
IL19Interleukin-19. (177 aa)
IFNKInterferon kappa. (208 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
IL6RInterleukin-6 receptor subunit alpha. (483 aa)
LOC110573273Signal transducer and activator of transcription 5B. (600 aa)
GFAPGlial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. (432 aa)
JAK1Tyrosine-protein kinase. (1156 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IL23RInterleukin-23 receptor. (631 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IL2RGCytokine receptor common subunit gamma. (374 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (331 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
ZANLOW QUALITY PROTEIN: zonadhesin. (2782 aa)
IL12RB2Interleukin-12 receptor subunit beta-2 isoform X1. (861 aa)
LEPRLeptin receptor. (1166 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
IL10RBInterleukin-10 receptor subunit beta. (375 aa)
CRLF2Cytokine receptor-like factor 2. (370 aa)
IL3RAInterleukin-3 receptor subunit alpha. (376 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IFNGR2Interferon gamma receptor 2 isoform X1. (356 aa)
IL20RBInterleukin-20 receptor subunit beta isoform X1. (294 aa)
IL17Dinterleukin-17D. (209 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (516 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL22Interleukin-22. (179 aa)
LOC110570393Somatotropin. (216 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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