STRINGSTRING
ARPC5 ARPC5 PTPRC PTPRC SPHK1 SPHK1 SPHK2 SPHK2 AKT1 AKT1 VASP VASP ARPC1A ARPC1A ARPC1B ARPC1B PIK3CB PIK3CB WAS WAS PRKCA PRKCA WASF3 WASF3 INPP5D INPP5D WASF1 WASF1 JMJD7 JMJD7 PLA2G4F PLA2G4F PLA2G4B PLA2G4B PLA2G4D PLA2G4D MARCKS MARCKS SYK SYK PLD2 PLD2 CFL2 CFL2 ASAP2 ASAP2 PLA2G4E PLA2G4E BIN1 BIN1 FCGR2B FCGR2B FCGR3A FCGR3A LAT LAT DOCK5 DOCK5 MAPK3 MAPK3 PRKCE PRKCE CCDC125 CCDC125 PIK3R1 PIK3R1 PLPP1 PLPP1 PLD1 PLD1 NCF1 NCF1 LIMK1 LIMK1 AKT2 AKT2 AMPH AMPH LIMK2 LIMK2 ARF6 ARF6 LOC110591567 LOC110591567 GAB2 GAB2 PAK1 PAK1 MYO10 MYO10 PLPP2 PLPP2 DNM2 DNM2 ARPC2 ARPC2 RPS6KB1 RPS6KB1 INPPL1 INPPL1 DOCK1 DOCK1 CRK CRK PIP5K1C PIP5K1C PLCG2 PLCG2 VAV1 VAV1 RAF1 RAF1 PRKCD PRKCD PIP5K1B PIP5K1B GOLGA2 GOLGA2 VAV2 VAV2 PIK3CA PIK3CA ARPC5L ARPC5L GSN GSN VAV3 VAV3 BOLA1 BOLA1 SCIN SCIN MAPK1 MAPK1 LOC110577769 LOC110577769 RAC2 RAC2 ARPC4 ARPC4 PLCG1 PLCG1 PRKCB PRKCB ASAP1 ASAP1 LYN LYN PIP5K1A PIP5K1A LOC110578553 LOC110578553 CRKL CRKL PLA2G6 PLA2G6 CDC42 CDC42 PIK3CD PIK3CD PIK3R3 PIK3R3 RPS6KB2 RPS6KB2 CFL1 CFL1 PLPP3 PLPP3 MARCKSL1 MARCKSL1 ASAP3 ASAP3 WASF2 WASF2 PRKCG PRKCG PIK3R2 PIK3R2 PLA2G4A PLA2G4A AKT3 AKT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1190 aa)
SPHK1Sphingosine kinase 1 isoform X1. (487 aa)
SPHK2Sphingosine kinase 2. (656 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (375 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
WASwiskott-Aldrich syndrome protein. (410 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
WASF3wiskott-Aldrich syndrome protein family member 3. (502 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1160 aa)
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X1. (559 aa)
JMJD7jmjC domain-containing protein 7. (316 aa)
PLA2G4FPhospholipase A2. (860 aa)
PLA2G4BPhospholipase A2. (782 aa)
PLA2G4DPhospholipase A2. (817 aa)
MARCKSMyristoylated alanine-rich C-kinase substrate. (333 aa)
SYKTyrosine-protein kinase. (635 aa)
PLD2Phospholipase. (933 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
ASAP2arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2. (968 aa)
PLA2G4EPhospholipase A2. (841 aa)
BIN1Myc box-dependent-interacting protein 1 isoform X4. (594 aa)
FCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b. (295 aa)
FCGR3ALow affinity immunoglobulin gamma Fc region receptor III-A. (248 aa)
LATLinker for activation of T-cells family member 1. (256 aa)
DOCK5Dedicator of cytokinesis protein 5; Belongs to the DOCK family. (1902 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
CCDC125Coiled-coil domain-containing protein 125 isoform X1. (518 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PLPP1Phospholipid phosphatase 1 isoform X1. (285 aa)
PLD1Phospholipase. (1040 aa)
NCF1Neutrophil cytosol factor 1 isoform X1. (391 aa)
LIMK1LIM domain kinase 1. (644 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AMPHAmphiphysin isoform X1. (686 aa)
LIMK2LIM domain kinase 2 isoform X1. (631 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
LOC110591567Unconventional myosin-X-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (423 aa)
GAB2GRB2-associated-binding protein 2. (678 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
MYO10Unconventional myosin-X. (945 aa)
PLPP2Phospholipid phosphatase 2 isoform X1. (288 aa)
DNM2Dynamin-2 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1264 aa)
DOCK1Dedicator of cytokinesis protein 1; Belongs to the DOCK family. (1908 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (701 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1200 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
GOLGA2Golgin subfamily A member 2 isoform X1. (1037 aa)
VAV2Guanine nucleotide exchange factor VAV2. (862 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
GSNGelsolin isoform X1. (777 aa)
VAV3Guanine nucleotide exchange factor VAV3. (847 aa)
BOLA1bolA-like protein 1; Belongs to the BolA/IbaG family. (137 aa)
SCINAdseverin. (715 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LOC110577769Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
ASAP1arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1. (1112 aa)
LYNTyrosine-protein kinase. (512 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
LOC110578553High affinity immunoglobulin gamma Fc receptor I-like. (350 aa)
CRKLCrk-like protein. (303 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2 isoform X3. (807 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (219 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
MARCKSL1MARCKS-related protein. (199 aa)
ASAP3LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3. (902 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (499 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
PLA2G4APhospholipase A2. (733 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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